Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Predicting Graft Loss in a Population of Kidney Transplant Patients Diagnosed With ABMR/TG
J. Reeve,¹ P. Halloran.¹
¹Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ²Medicine, University of Alberta, Edmonton, AB, Canada.
ABMR is the main cause of late graft loss in kidney transplants. Our goal was to determine the variables most strongly predictive of graft loss…
2015 American Transplant Congress
Impact of Community Risk on Early Hospital Readmission Following Kidney Transplant
E. King,¹ L. Kucirka,¹ M. McAdams-DeMarco,^1,2 A. Massie,^1,2 J. Schold,³ D. Segev.^1,2
¹Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD; ²Epidemiology, Johns Hopkins University, School of Public Health, Baltimore, MD; ³Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
Background: Early hospital readmission (EHR) is associated with increased morbidity, mortality, and cost in kidney transplantation (KT). Community risk may be associated with EHR above…
2015 American Transplant Congress
Six Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Mismatched Living Donor Renal Transplant Recipients
J. Leventhal, M. Abecassis, L. Gallon, J. Galvin, J. Mehta, K. Ravindra, D. Tollerud, M. Elliott, S. Ildstad.
Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL; Duke University, Durham, NC; Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; Regenerex, LLC, Louisville, KY.
27 subjects have been transplanted in a phase 2 protocol (IDE 13947) based upon tolerogenic CD8+/TCR- facilitating cells (FCRx) and 200 cGy TBI-based nonmyeloablative conditioning…
2015 American Transplant Congress
Everolimus Versus Mycophenolate for Recipients of Kidney Transplants from Expanded Criteria Donors (ECD) Receiving Anti-Thymocyte Globulin and Tacrolimus
H. Tedesco-Silva,¹ C. Felipe,¹ A. Ferreira,¹ M. Cristelli,¹ A. Bessa,¹ P. Ueno,¹ T. Sandes- Freitas,¹ G. Bassos,¹ W. Aguiar,² H. Proença,³ J. Medina-Pestana.¹
¹Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ²Urology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ³Pathology, UNIFESP, Sao Paulo, Brazil.
Introduction: Recipients of kidneys recovered from expanded criteria donors are at higher risk to develop delayed graft function (DGF) and acute rejection (AR), leading to…
2015 American Transplant Congress
Survival Benefit of Kidney Transplant Among HIV+ Waitlist Candidates
J. Locke,¹ S. Gustafson,² C. Durand,³ J. Snyder,² B. Shelton,¹ R. Reed,¹ P. MacLennan,¹ S. Mehta,¹ A. Nellore,¹ D. Segev.^2,3
¹University of Alabama, Birmingham, AL; ²Scientific Registry of Transplant Recipients (SRTR), Minneapolis Medical Research Foundation, Minneapolis, MN; ³Johns Hopkins University, Baltimore, MD.
Chronic diseases, such as end-stage renal disease (ESRD), are now the leading causes of death among HIV+ patients. Multiple studies have demonstrated the efficacy of…
2015 American Transplant Congress
Pregnancy Outcomes in Female Kidney Transplant Recipients: Does Ethnicity Have an Influence?
S. Constantinescu,^1,2 L. Coscia,² D. Armenti,² P. Axelrod,¹ M. Ghanta,¹ S. Rao,¹ M. Moritz.^2,3
¹Temple University School of Medicine, Philadelphia; ²National Transplantation Pregnancy Registry, Gift of Life Institute, Philadelphia; ³Lehigh Valley Health Network, Allentown.
The purpose of this study was to analyze pregnancy outcomes in female kidney transplant recipients by ethnicity. Data were collected by the National Transplantation Pregnancy…
2015 American Transplant Congress
Influence of Race on P-Glycoprotein Function in Peripheral Blood Mononuclear Cells
K. Tornatore,¹ H. Minderman,² K. O'Loughlin,² K. Attwood,³ D. Brazeau,⁴ R. Venuto.⁵
¹NYS Center of Excellence in Bioinformatics & Life Science, School of Pharmacy, Buffalo; ²Flow Cytometry Laboratories, Roswell Park Cancer Institute, Buffalo; ³Biostatistics, School of Public Health, Buffalo; ⁴University of New England; School of Pharmacy, Portland, ME; ⁵Medicine, School of Medicine; University at Buffalo, Buffalo, NY.
Purpose: African Americans (AA) renal transplant recipients (RTR) have poorer long term allograft survival compared to Caucasians(C) which may be attributed to racial differences in…
2015 American Transplant Congress
T-Cell Mediated Vascular Rejection Can Be Identified By the Combined Measurement of Five Specific microRNAs in Blood
M. Matz,¹ K. Fabritius,¹ C. Lorkowski,¹ M. Dürr,¹ J. Gaedeke,¹ P. Durek,² J. Grün,² A. Goestemeyer,¹ F. Bachmann,¹ K. Wu,¹ B. Rudolph,¹ U. Weber,¹ C. Haftmann,² N. Unterwalder,³ N. Lachmann,¹ A. Radbruch,² H.-H. Neumayer,¹ M.-F. Mashreghi,² K. Budde.¹
¹University Medicine Charité, Berlin, Germany; ²German Rheumatism Research Centre, Berlin, Germany; ³Labor Berlin GmbH, Berlin, Germany.
MicroRNAs hold important roles in the regulation of gene expression. Their function has been correlated with kidney disease and they might represent a new class…
2015 American Transplant Congress
Immunosuppression With Anti-CD40 mAb and Rapamycin for Islet and Kidney Co-Transplantation in Nonhuman Primates
T. Oura, K. Hotta, J. Lei, J. Markmann, A. Dehnadi, G. Benichou, B. Cosimi, T. Kawai.
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: For patients with end-stage renal disease secondary to type 1 diabetes mellitus, islet and kidney co-transplantation can be an ideal transplant option. However, a…
2015 American Transplant Congress
Glucose Chemical Exchange Saturation Transfer MRI of Acute Renal Allograft Rejection
D. Kentrup,¹ A. Busch,² H. Pawelski,¹ V. Hoerr,^2,3 S. Reuter.¹
¹Department of Medicine D, University Hospital Münster, Münster, Germany; ²Department of Clinical Radiology, University Hospital Münster, Münster, Germany; ³Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
Purpose: During acute rejection episodes large amounts of immune cells infiltrate renal grafts, leading to inflammation accompanied by an increased glucose metabolism.Given these circumstances we…