ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Kidney transplantation"

  • 2015 American Transplant Congress

    Pharmacokinetics of Everolimus (EVL) in Elderly Recipients Under Low-Tacrolimus(TAC)/Everolimus in the First Year After Renal Transplantation. Data from the NEverOLd Trial

    E. David-Neto,1 P. Romano,2 F. Agena,1 P. Ebner,2 A. Triboni,1 F. Ramos,1 N. Galante,1 F. Lemos.1

    1Renal Transplantation Service, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; 2Division of Central Laboratory, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.

    Elderly ( >60 years) recipients are being renal transplanted more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include…
  • 2015 American Transplant Congress

    Outcomes of Kidney Transplant Recipients Minimally Immunosuppressed: A Cohort Study Analysis

    A.-H. Querard,1,2,3 F. Gillaizeau,2,1 G. Couvrat-Desvergne,1,2,3 J. Dantal,1,4,5 P. Daguin,1 S. Le Floch,1 S. Castagnet,6 S. Brouard,1,4 Y. Foucher,2,1 M. Giral.1,2,4,5

    1Institute for Transplantation, Urology and Nephrology (ITUN), CHU Nantes, RTRS « Centaure », INSERM U1064, Université de Nantes, Nantes, France; 2EA 4275 SPHERE– Biostatistics, Pharmacoepidemiology and Human Sciences Research, Nantes University, Nantes, France; 3Centre Hospitalier Departemental de Vendée, La Roche sur Yon, France; 4Centre d'Investigation Clinique Biothérapie, Nantes, France; 5Centre Hospitalier Universitaire, Nantes, France; 6HLA Laboratory, Etablissement Français du Sang, Nantes, France.

    Background: Renal transplantation is the treatment of choice for endstage renal disease. Nevertheless, it involves immunosuppressive treatments with Serious Adverse Events (SAE) such as infections…
  • 2015 American Transplant Congress

    Risk Factors for Acute Cellular Rejection for Pediatric Kidney Transplant Recipients

    D. Cote,1 I. Bobanga,1 B. Vogt,2 K. Dell,2 R. Cunningham III,2 K. Noon,1 V. Humphreville,1 E. Sanchez,1 J. Schulak,1 K. Woodside.1

    1Department of Surgery, Case Western Reserve University & University Hospitals, Cleveland, OH; 2Department of Pediatrics, Case Western Reserve University & University Hospitals, Cleveland, OH.

    Background: Acute cellular rejection (ACR) potentially shortens the life of a kidney allograft. We sought to determine risk factors associated with the development of ACR…
  • 2015 American Transplant Congress

    The Explore Transplant Program in GA: Is Historical Access to Transplantation Associated With Kidney Transplant Knowledge and Preparedness to Educate ERSD Patients?

    J. Gander,1 C. Isenhour,1 L. McPherson,1 M. Basu,1 B. Tao,1 K. Smtih,1 S. Pastan,1 A. Waterman,2 R. Patzer.1

    1Emory University, Atlanta; 2University of California, Los Angeles.

    IntroductionDialysis facilities play a key role in educating end stage renal disease patients on kidney transplantation (KTx). We aimed to investigate the association between historical…
  • 2015 American Transplant Congress

    Long-term Patient and Graft Survival After Kidney Transplantation in Recipients With Hepatitis C Virus Infection

    N.-Y. Heo, P. Udompap, A. Mannalithara, W. Kim.

    Division of Gastroenterology and Hepatology, Stanford University, Stanford.

    Background: The prevalence of hepatitis C virus (HCV) infection among kidney transplant (KTx) recipients is higher than that in the general population. With the advent…
  • 2015 American Transplant Congress

    Clinical Subclassifiation of ABMR Phenotypes: Recognizing Variation in Presentation

    P. Halloran, M. Lopez, I. Salazar, J. Chang.

    Alberta Transplant Applied Genomics Centre, Edmonton, Canada.

    The diagnosis of ABMR in kidney transplants is based on ptc-, g- and cg-lesions in biopsies and donor-specific antibody (DSA). To recognize the actual phenotypes…
  • 2015 American Transplant Congress

    The Economic Impact of Nonimmune Complications in Contemporary Kidney Transplantation

    K. Lentine,1 M. Schnitzler,1 D. Axelrod,2 D. Segev,3 D. Brennan,4 J. Tuttle-Newhall,1 H. Xiao,1 L. Kucirka,3 V. Dharnidharka.4

    1Saint Louis Univ, St Louis; 2Dartmouth, Lebanon; 3Johns Hopkins, Baltimore; 4Washington Univ, St. Louis.

    The clinical burden and economic impacts of nonimmune complications after kidney transplant (KT) are incompletely defined.We examined United States Renal System Registry Data for Medicare-insured…
  • 2015 American Transplant Congress

    Assessment of IgG Subclass Significance for Early Graft Rejection and Long-Term Survival in HLA-Antibody Incompatible Renal Transplantation: Multivariate Approach

    N. Khovanova,1 D. Lowe,2 S. Daga,1,3 T. Shaikhina,1 N. Krishnan,3 D. Mitchell,1 D. Zehnder,1 D. Briggs,2 R. Higgins.3

    1University of Warwick, Coventry, United Kingdom; 2NHS Blood and Transplant, Birmingham, United Kingdom; 3University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.

    Donor HLA specific antibodies (DSA) can cause acute rejection and graft lost after renal transplantation. However neither the damaging antibody types, nor their acceptable levels…
  • 2015 American Transplant Congress

    Loss of RIPK3 and Caspase-8 Enhance Intrinsic Apoptosis in Tubular Epithelial Cell (TEC) Death and Contributes to Kidney Ischemia Reperfusion Injury (IRI)

    B. Sung,1 Y. Su,3 A. Lau,3 J. Jiang,3 A. Haig,2 D. Green,4 Z. Zhang,2 A. Jevnikar.1

    1Microbiology and Immunology, Western University, London, ON, Canada; 2Pathology, Western University, London, ON, Canada; 3Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; 4St. Jude Children's Research Hospital, Memphis, TN.

    [Background] Ischemia-reperfusion injury (IRI), a complex limiting factor in organ transplant survival, is related to multiple death pathways. Eliminating the key necroptotic molecule (RIPK3) improves…
  • 2015 American Transplant Congress

    Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus

    H. Tedesco-Silva,1 C. Felipe,1 A. Ferreira,1 M. Cristelli,1 T. Sandes- Freitas,1 N. Oliveira,1 W. Aguiar,2 G. Bassos,1 M. Franco,3 M. Gerbase- Lima,4 E. Campos,4 J. Medina-Pestana.1

    1Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; 2Urology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; 3Pathology, UNIFESP, Sao Paulo, Brazil; 4Immunogenetic, AFIP, Sao Paulo, Brazil.

    BACKGROUND: CMV infection is associated with inferior long-term kidney transplant outcomes. This study compared the incidence of CMV infection/disease in de novo kidney transplant recipients…
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