Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Survival of Patients With Peripheral Vascular Disease on Kidney Waitlist and After Transplantation: An Analysis of the United State Renal Data System
A. Brar,¹ D. Stefanov,³ R. Jindal,² N. Sumrani,⁴ D. John,⁴ F. Tedla,¹ M. Salifu.¹
¹Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY; ²Department of Surgery, Walter Reed National Military Medical Center, Uniformed Services University of Health Sciences, Bethesda, MD; ³Division of Research, SUNY Downstate School of Medicine, Brooklyn, NY; ⁴Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY.
Introduction: There is lack of information whether waitlisted dialysis patients with peripheral vascular disease (PVD) benefit from kidney transplantation.Methods: We used a cohort of USRDS…
2015 American Transplant Congress
Treatment Patterns, Healthcare Resource Utilization, and Costs in Kidney Transplant Recipients Using a Fixed Source Regimen of Tacrolimus Vs. a Variable Source Regimen
E. Lee,¹ S. Bunniran,² P. Kamble,² B. Suehs,² B. Franks,¹ J. Schwartz,¹ C. Anderson,³ G. Thal,¹ J. Spalding.¹
¹Astellas Scientific and Medical Affairs, Northbrook, IL; ²Comprehensive Health Insights, Humana, Louisville, KY; ³Humana, Louisville, KY.
BackgroundTacrolimus (TAC) has evolved to be the foundation of kidney transplant immunosuppressant protocols. However, the implications of switching between multiple formulations of TAC have not…
2015 American Transplant Congress
Third Party Mesenchymal Stromal Cell Infusion in Kidney Transplant Recipient: 6-Month Safety Interim Analysis
L. Weekers,¹ P. Erpicum,¹ O. Detry,³ C. Lechanteur,² E. Baudoux,² F. Jouret,¹ Y. Beguin.²
¹Nephrology, University Hospital of Liege, Liege, Belgium; ²Hematology, University Hospital of Liege, Liege, Belgium; ³Abdominal Surgery, University Hospital of Liege, Liege, Belgium.
Back-groundMesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents.We report the 6-month safety results for the 5 first patients treated…
2015 American Transplant Congress
The Natural History of Kidney Graft Cortical Microcirculation Determined by Real-Time Contrast-Enhanced Sonography (RT-CES)
C. Jiménez,¹ M. López,¹ A. Ros,¹ A. Aguilar,¹ D. Menendez,¹ B. Rivas,¹ M. Santana,¹ R. Madero,² R. Selgas.¹
¹Nephrology, Hospital Univeritario La Paz, Madrid, Spain; ²Biostatistics, Hospital Univeritario La Paz, Madrid, Spain.
Decreasing kidney graft cortical microcirculation has been related to poor prognosis in kidney transplantation. Cortical capillary blood flow (CCBF) can be measured by real-time contrast-enhanced…
2015 American Transplant Congress
What Can UNOS Data Tell Us About Patient Outcomes After Primary Renal Allograft Failure?
A. Frank,¹ A. Shah,¹ P. Singh.²
¹Surgery, Thomas Jefferson University, Philadelphia, PA; ²Medicine, Thomas Jefferson University, Philadelphia, PA.
Evidence based approaches to patient care after Renal Allograft Failure do not exist, despite this being a high mortality period. Access to retransplantation is important…
2015 American Transplant Congress
Preserved Kidney Volume in Living Kidney Donors: Correlation With 2 Year Renal Function Using CKD-EPI Equation to Predict Remaining GFR
A. Khalil,¹ M. Yaqub,¹ T. Taber,¹ J. Powelson,¹ C. Sundaram,¹ W. Goggins,¹ D. Mishler,¹ M. Mujtaba,¹ A. Diez,² A. Sharfuddin.¹
¹Indiana University; ²Ohio State University, Columbus.
Background: The aim of our study was to evaluate whether preserved kidney volume correlates with donor renal function at 2-years post-donation using the CKD-EPI eGFR…
2015 American Transplant Congress
Early Weight Gain After Transplantation Can Cause Adverse Effect On Transplant Kidney Function
S. Choi, I.-K. Kim, S. Son, M. Ju.
Surgery, Gangnam Severance Hospital, Yonsei College of Medicine, Seoul, Korea.
Background: Outcomes of kidney transplant recipients with increased body mass index (BMI) remain controversial. We studied the relationship between change of BMI and transplant kidney…
2015 American Transplant Congress
Measuring Affinity of Polyclonal HLA-Specific Antibodies in Highly Sensitised Cases Can Serve as an Additional Biomarker to Guide Direct Transplantation
S. Daga,^1,2 D. Lowe,⁶ R. Buchli,³ J. Collard,³ A. Mulder,⁸ C. McMurtrey,^3,4 H. Moyse,⁷ N. Evans,⁷ N. Krishnan,² W. Hildebrand,^3,4 F. Claas,⁸ D. Briggs,⁵ D. Zehnder,^1,2 D. Mithcell,¹ R. Higgins.^1,2
¹Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; ²Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; ³Pure Protein LLC, Oklahoma; ⁴University of Oklahoma Health Science Center, Oklahoma City; ⁵Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; ⁶Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; ⁷School of Engineering, University of Warwick, Coventry, United Kingdom; ⁸Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Significant numbers of patients on transplant waiting lists in the UK are sensitised (43%). Direct transplantation across these HLA-specific antibodies using risk stratification strategies are…
2015 American Transplant Congress
Immune Phenotyping of Peripheral Blood Samples from the CTOT-10 Belatacept Study
Y. Suessmuth,¹ L. Stempora,¹ B. Johnson,¹ J. Cheeseman,¹ Y. Morrison,⁴ N. Bridges,⁴ D. Ikle,⁵ S. Tomlanovich,³ P. Stock,³ R. Mannon,² K. Newell,¹ C. Larsen,¹ A. Mehta.¹
¹Emory Transplant Center, Atlanta; ²University of Alabama, Birmingham; ³University of California San Francisco, San Francisco; ⁴NIAID/ NIH, Bethesda; ⁵Rho, Chapel Hill, NC.
The purpose of the CTOT-10 study is to evaluate belatacept as maintenance therapy, while minimizing calcineurin inhibitors and corticosteroids in renal transplantation. We designed mechanistic…
2015 American Transplant Congress
Lessons Learned from the Clinical Use of Normothermic Regional Perfusion (nRP) in Uncontrolled Donation After Circulatory Death (DCD)
C. Antoine,¹ E. Savoye,¹ F. Gaudez,² G. Cheisson,³ M. Videcoq,⁴ B. Barrou,⁵ National Steering Committee of Donation After Circulatory Death.¹
¹Medical and Scientific Department, Agence de la Biomedecine, LA Plaine Saint Denis, Saint Denis, France; ²Department of Urology, Saint Louis Hospital, Paris, France; ³Department of Anesthesia and Critical Care, Bicetre Hospital, Kremlin Bicetre, Val de Marne, France; ⁴Department of Transplantation, Edouard Herriot Hospital Group, Lyon, Rhones Alpes, France; ⁵Department of Anesthesia and Critical Care, Hôtel-Dieu Hospital, Nantes, Pays de la Loire, France; ⁶Department of Urology, University Hospital La Pitie, Paris, France.
The national protocol for the uDCD program restricts donor age < 55 y, no flow period < 30 min and total warm ischemia time (WIT)…