Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Effect of Extension in Submucosal Ureteral Tunnel to Prevent Vesicoureteral Reflux and Its Impact on the Graft Survival in Kidney Transplantation
T. Inoue,¹ S. Satoh,² M. Saito,¹ K. Numakura,¹ H. Tsuruta,¹ S. Akihama,¹ S. Narita,¹ N. Tsuchiya,¹ T. Habuchi.¹
¹Urology, Akita University, Akita, Japan; ²Center for Kidney Disease, Akita University, Akita, Japan.
Objects: It is plausible that vesicoureteral reflux (VUR) induced by an insufficient length of a submucosal ureteral tunnel leads graft function to deteriorate in kidney…
2015 American Transplant Congress
Evaluation of Preformed Anti-HLA Antibody of "Unknown Origin" after Kidney Transplant in a Brazilian Center
D. Glasberg,¹ D. Monteiro de Carvalho,² T. Matuck,² G. Fabricio-Silva,³ M. Barbosa,¹ A. Borela,¹ L. Christiani,¹ R. Malta,¹ L. Porto.³
¹Nephrology, Bonsucesso Federal Hospital, Rio de Janeiro, Brazil; ²Transplant Service, São Francisco de Assis Hospital, Rio de Janeiro, Brazil; ³Histocompatibility and Cryopreservation Laboratory, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Background: The use of single antigen beads assay (SAFB) for the detection of anti-HLA antibodies (Abs) may reveal the presence of Abs in individuals without…
2015 American Transplant Congress
Activation of Th17 and Chronic Renal Allograft Rejection in Nonhuman Primates
K. Hotta, A. Aoyama, P. Putheti, Y. Yamada, T. Ohura, R. Colvin, B. Cosimi, G. Benichou, T. Strom, T. Kawai.
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: We have previously reported successful induction of renal allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Although donor specific Th1 and…
2015 American Transplant Congress
Graft Outcome Disparity in a Single Renal Transplant Center Based on Recipient Geographic Origin
R. Flynn, W. Qu, D. Fumo, T. Suttle, S. Selman, M. Rees, J. Ortiz.
University of Toledo Medical Center, Toledo, OH.
PURPOSE: The disparity in access to organs for kidney transplantation has led to inter-state “transplant tourism.” Our objective was to determine if recipients traveling over…
2015 American Transplant Congress
Interleukin-17 Deficiency Attenuates Renal Allograft Injury and Prolongs Survival in a Murine Transplantation Model
T. Kwan,^1,2 S. Chadban,^1,2 J. Ma,^1,2 S. Bao,^2,3 S. Alexander,^2,4 H. Wu.^1,2
¹Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; ²Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; ³Discipline of Pathology, School of Medical Sciences, Sydney, New South Wales, Australia; ⁴Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Aim:To investigate the role of IL-17 in allograft rejection using a murine model of fully MHC-mismatched renal transplantation.Methods:Life-sustaining kidney transplants were performed in nephrectomized mice:…
2015 American Transplant Congress
Influence of CYP3A5 and ABCB1 Genotypes on Pharmacokinetics of Immediate and Prolonged Release Tacrolimus Preparations
T. Elnahhas,^1,2 T. Lee,² M. Moreton,² D. McKeown,² J. Popoola,³ R. Ramkhelawon,³ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology Department, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St.George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St.George's University of London, London, United Kingdom.
Background. Tacrolimus is available in two formulations, immediate-release, (Prograf®) and prolonged -release formulation of tacrolimus (Advagraf®). Tacrolimus has a narrow therapeutic index with wide variation…
2015 American Transplant Congress
Month 48 Follow-Up Results of HERAKLES Trial on Three Different Treatment Regimen and Switching Off Behaviour in De Novo Renal Transplant Patients
W. Arns,¹ K. Budde,¹ C. Sommerer,¹ O. Witzke,¹ M. Guba,¹ J. Jacobi,¹ B. Vogt,³ P. Reinke,¹ I. Hauser,¹ R. Stahl,¹ T. Rath,¹ D. Baeumer,² M. Porstner,² M. Zeier,¹ F. Lehner,¹ V. Kliem.¹
¹Herakles Study Group, Germany; ²Novartis, Pharma, Germany; ³Herakles Study Group, Switzerland.
Aim: To compare switching off 3 different immunosuppressive (IS) regimen 4years after renal transplantation (Tx).Methods: 802 patients (pts) were included in this prospective, open-label, randomized,…
2015 American Transplant Congress
Risk Factors for Graft Loss in Pediatric Renal Transplant Recipients After Transfer of Care
B. Coyne,^1,2 P. Hollen,^1,2 Y. Guofen,³ K. Brayman.⁴
¹Department of Pediatrics, University of Virginia Health System, Charlottesville, VA; ²School of Nursing, University of Virginia, Charlottesville, VA; ³Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA; ⁴Department of Surgery, University of Virginia Health System, Charlottesville, VA.
Improvements in immunosuppression and transplant surgical technique have increased the survival of children with end-stage renal disease. These patients have complex needs, and the current…
2015 American Transplant Congress
Renal Cell Carcinoma in the Native Kidney in Dialysis and Kidney Transplantation Recipients. Different Entities?
K. Yamaçake, W. Nahas, H. Kanashiro, R. Kato, A. Bull, I. Antonopoulos, R. Falci, A. Piovesan.
Division of Urology, Renal Transplantation Unit, University of São Paulo, São Paulo, SP, Brazil.
Purpose: Renal Cell Carcinoma (RCC) has a high incidence in patients with acquired cystic kidney disease (ACKD) due to hemodialysis. It has been reported that…
2015 American Transplant Congress
Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function
A. Gilbert,¹ E. Hall,¹ O. Timofeeva,² M. Awwad,² M. Grafals,¹ P. Weems,¹ D. Li,² S. Rosen-Bronson,² J. Moore,¹ B. Javaid,¹ M. Cooper.¹
¹Department of Surgery, MedStar Georgetown Transplant Institute, Washington, DC; ²Department of Pathology, MedStar Georgetown Transplant Institute, Washington, DC.
Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…