Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Operational Tolerance in Kidney Transplantation: Results of a Europe-Wide Survey
A. Massart,¹ A. Pallier,² O. Viklicky,^3,4 J. Pascual,^3,5 K. Budde,^3,6 S. Sorensen,^3,7 R. Oberbauer,^3,8 M. Klinger,^3,9 C. Dudley,^3,10 M. Sever,^3,11 G. Spasovski,^3,13 P. Guérif,² U. Maggiore,^3,12 M. Abramowicz,¹ M. Giral,² D. Abramowicz,¹⁴ S. Brouard.²
¹Erasme, Brussels, Belgium; ²Nantes University, Nantes, France; ³ERA-EDTA-DESCARTES Working Group, Parma, Italy; ⁴IKEM, Prague, Czech Republic; ⁵Hospital del Mar, Barcelona, Spain; ⁶CCM, Berlin, Germany; ⁷Rigshospitalet, Copenhagen, Denmark; ⁸KH Elisabethinen, Linz, Austria; ⁹WMU, Wrocław, Poland; ¹⁰NBT, Bristol, United Kingdom; ¹¹IMSSC, Istanbul, Turkey; ¹²Ospedale Maggiore, Parma, Italy; ¹³UCC, Skopje, Macedonia, The Former Yugoslav Republic of; ¹⁴UZA, Antwerpen, Belgium.
BACKGROUND: Operational Tolerance (opTOL) is deemed to be extremely rare in kidney transplantation. We launched a Europe-wide survey to assess the frequency of opTOL.METHODS: 18…
2015 American Transplant Congress
Outcomes of Post-Kidney Transplant Leukemias
B. Rouphael, A. Kukla, K. Gillingham, H. Ibrahim, A. Matas, N. Issa.
Medicine, University of Minnesota, Minneapolis, MN.
Background:Leukemias typically portend bad prognosis in the general population. The incidence and outcomes of post-kidney transplant leukemias (PKTL) have not been well studied as most…
2015 American Transplant Congress
Comparative Survival Benefits and Costs of an Eplet and Broad Antigen Based Matching System in Deceased Donor Kidney Transplant Allocation Among Indigenous Australians
H. Do Nguyen,¹ G. Wong,^2,3 J. Chapman,² J. Craig,^2,3 L. D'Orsogna,⁴ W. Lim.^1,5
¹School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; ²Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; ³School of Medicine, University of New South Wales, Sydney, New South Wales, Australia; ⁴Clinical Immunology, Royal Perth Hospital, Perth, Western Australia, Australia; ⁵Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Aim: To compare the benefits and costs of incorporating an eplet-based matching algorithm to the current allocation of deceased donor kidneys to indigenous Australians.Background: The…
2015 American Transplant Congress
Explorative Analysis of ZEUS After 5 Years: Histological Assessment from Biopsy Analyses
U. Eisenberger,¹ K. Budde,¹ O. Witzke,¹ F. Lehner,¹ C. Sommerer,¹ R. Wuethrich,³ P. Reinke,¹ A. Muehlfeld,¹ K. Heller,¹ R. Stahl,¹ H. Wolters,¹ I. Hauser,¹ M. Porstner,² W. Arns.¹
¹ZEUS Study Group, Germany; ²Novartis, Pharma, Germany; ³ZEUS Study Group, Switzerland.
Background: Analysis of pathologists' assessments and histological data allow for deeper insight on patient outcome together with investigator's final clinical diagnoses. Here we present 5…
2015 American Transplant Congress
Calcineurin Inhibitors (CNI) Minimization Associated With Mammalian Target of Rapamycin Inhibitors (i-mTOR) to Improve Renal Function in Renal Grafts from Uncontrolled Donation After Cardiac Death Donors (UDCDD)
M. Molina,¹ E. Gutierrez,¹ S. González-Sanchidrian,² E. González,¹ J. Cabrera,¹ N. Polanco,¹ A. Hernández,¹ A. Sevillano,¹ M. Praga,¹ A. Andres.¹
¹Nephrology, Hospital 12 de Octubre, Madrid, Spain; ²Nephrology, Hospital San Pedro de Alcántara, Caceres, Spain.
INTRODUCTION: Ischemia injury in kidneys grafts from UDCDD could produce a poor renal function. Minimized blood levels of CNI associated with i-mTOR therapy could avoid…
2015 American Transplant Congress
The Clinical Outcome of Plasma Cell-Rich Rejection of Kidney Allograft
J. Hasegawa,¹ K. Honda,² S. Wakai,¹ H. Shirakawa,³ M. Okumi,³ K. Omoto,³ H. Ishida,³ K. Tanabe.³
¹Nephrology, Ohkubo Hospital, Tokyo, Japan; ²Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background: Plasma cell-rich rejection (PCRR) is a rare type of allograft rejection characterized by the presence of mature plasma cells. This type of rejection has…
2015 American Transplant Congress
Living Donor Transplant Rates in Children Are Declining
D. Keith, A. Nishio Lucar, G. Vranic.
University of Virginia, Charlottesville, VA.
Living donor (LD) transplant rates have been declining since 2004 in adult candidates. We sought to determine if this trend is also occurring in pediatric…
2015 American Transplant Congress
Noninvasive Diagnostic and Predictive Value in Renal Transplant Recipients by Measurement of Urine BCA-1
D. Chen, J. Chen, W. Peng.
Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Nephropathy, Zhejiang Province; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese.
ObjectiveTo investigate the relationship between early-stage renal acute rejection and the level of BCA-1 in urine, explore the diagnostic value and noninvasive monitoring in early…
2015 American Transplant Congress
A Novel, Blocking Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B-Cell Depletion Or Thromboembolic Events
J. Rush,¹ G. Wieczorek,¹ M. Audet,² M. Schneider,¹ P. Espie,³ L. Roth,¹ C. Heusser,¹ C. Bruns,¹ D. Patel,¹ F. Cordoba.¹
¹Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland; ²Hôpital de Hautepierre, Strasbourg, France; ³Drug Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Background. CD40-CD154 pathway blockade prolongs renal allograft survival in non-human primates (NHPs). However, antibodies targeting CD154 were associated with an increased incidence of thromboembolic complications…
2015 American Transplant Congress
New SRTR Risk-Adjustment Models for Adult Kidney Transplant Outcomes
J. Snyder,¹ N. Salkowski,¹ D. Zaun,¹ H. Xiong,¹ S. Leppke,¹ B. Thompson,¹ D. Segev,^1,2 L. Hunsicker,¹ A. Israni,¹ B. Kasiske.¹
¹Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; ²Johns Hopkins University, Baltimore, MD.
Following a recommendation of the Consensus Conference on Transplant Program Quality and Surveillance, SRTR implemented a 3-year rolling cycle to rebuild the statistical models used…