Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Customized Reminders and Provider Notification to Improve Adherence to Immunosuppression
P. Reese, R. Bloom, J. Trofe-Clark, A. Mussell, D. Leidy, S. Levsky, J. Zhu, Y. Lin, A. Troxel, H. Feldman, K. Volpp.
UPenn, Philadelphia, PA.
Background: Non-adherence to transplant immunosuppression is associated with an elevated risk of allograft loss. Novel, wireless-enabled pill bottles have created the opportunity to monitor patient…
2015 American Transplant Congress
Microvascular (MIA) and Interstitial (i) Inflammation Influence Late Death-Censored Graft Failure (DCGF) After Kidney Transplantation
R. Gaston,¹ A. Fieberg,² R. Leduc,² J. Connett,² F. Cosio,³ S. Gourishankar,⁴ J. Grande,³ L. Hunsicker,⁵ B. Kasiske,⁶ J. Cecka,⁷ A. Matas,² D. Rush.⁸
¹UAB, Birmingham; ²U Minnesota, Minneapolis; ³Mayo Clinic, Rochester; ⁴U Alberta, Edmonton, Canada; ⁵U Iowa, Iowa City; ⁶Hennepin County Med Ctr, Minneapolis; ⁷UCLA Immunogenetics, Los Angeles; ⁸U Manitoba, Winnipeg, Canada.
We and others have shown late DCGF is due to ongoing, most often immune, injury. Though there is general agreement that antibody-mediated injury is a…
2015 American Transplant Congress
Elective Allograft Nephrectomy After Transplant Failure
J. Augustine, K. Woodside, K. Noon, D. Hricik, E. Sanchez, J. Schulak.
University Hospitals, Transplant Institute, Cleveland, OH.
Background/Methods: Because of high rates of allograft intolerance and alloantibody sensitization after kidney transplant failure, we undertook a pilot study of elective allograft nephrectomy (ENx)…
2015 American Transplant Congress
Husband to Wife Renal Transplants Are Associated With a Higher Risk of Early Antibody Mediated Rejection and Transplant Glomerulopathy
H. Sawhney, M. Willicombe, P. Brookes, E. Santos, D. Taube.
Renal and Transplant Centre, Hammersmith Hospital, Imperial Healthcare NHS Trust, London, England, United Kingdom.
Patients with a low level preformed donor specific antibodies [DSA] with a negative FCXM/CDC cross match are at high risk of antibody mediated rejection [AMR]…
2015 American Transplant Congress
Kidney Transplantation in the Septuagenarian
H. Saucedo Crespo, B. Taner, M. Mai, H. Wadei, P. Perry, M. Prendergast, J. Nguyen, K. Oshel, J. Bruns, D. Lee, T. Gonwa.
Department of Transplantation, Mayo Clinic, Jacksonville, FL.
The elderly ESRD population in the US continues to grow. National data demonstrates that both patient (PS) and graft survival (GS) at 1 and 5…
2015 American Transplant Congress
Differences in Reactivity of HLA-Specific Antibodies May Be Explained By Differences in Their Affinities for Selected Epitopes on HLA Proteins
S. Daga,^1,2 D. Lowe,⁶ R. Buchli,⁵ J. Collard,⁵ A. Mulder,⁸ C. McMurtrey,^4,5 H. Moyse,⁷ N. Evans,⁷ N. Krishnan,² W. Hildebrand,^4,5 F. Claas,⁸ D. Briggs,³ D. Zehnder,^1,2 D. Mitchell,¹ R. Higgins.^1,2
¹Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; ²Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; ³Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; ⁴University of Oklahoma Health Science Center, Oklahoma City; ⁵Pure Protein LLC, Oklahoma City; ⁶Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; ⁷School of Engineering, University of Warwick, Coventry, United Kingdom; ⁸Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Affinity of IgG immunoglobulins for antigen varies and matures within the evolution of immune responses. Affinity is likely to be different for different epitope-antibody interactions…
2015 American Transplant Congress
Campath Induction With Triple Maintenance Therapy in African American Kidney Transplant Recipients: Less Infections But Worse Graft Survival
M. Gillespie, F. Rasetto, B. Masters, T. Sparkes, B. Ravichandran, M. Moss, A. Haririan.
University of Maryland Medical Center, Baltimore, MD.
Introduction:African American (AA) kidney transplant recipients (KTR) are at a higher risk for worse clinical outcomes vs non-AA. Strategies to improve outcomes in AA KTR…
2015 American Transplant Congress
High Kidney Donor Profile Index (KDPI) Correlates With Calculated Pulsatile Perfusion (PP) Resistance Index (RI) and Delayed Graft Function (DGF)
R. Pelletier, M. Henry.
Surgery/Transplant, The Ohio State University Medical Center, Columbus, OH.
Background: Deceased donor (DD) kidney quality is now being determined by calculating the Kidney Donor Profile Index (KDPI). Calculated kidney vascular resistance index (RI) during…
2015 American Transplant Congress
Socioeconomic Factors and Early Hospital Readmission After Kidney Transplant at a Single Center
J. Lin, E. King, R. Craig-Shapiro, C. Wickliffe, A. Massie, D. Segev.
Department of Surgery, Johns Hopkins School of Medicine, Baltimore.
Early hospital readmission (EHR) is a key negative outcome in kidney transplantation (KT). Socioeconomic (SE) factors are associated with EHR in other contexts, but have…
2015 American Transplant Congress
Efficacy of Rituximab Sparing Protocol for ABO Incompatible Renal Transplant in Patients With Low Titers
S. Narumi,¹ Y. Watarai,¹ N. Goto,¹ T. Hiramitsu,¹ T. Yamamoto,¹ M. Tsujita,¹ M. Okada,¹ K. Futamura,¹ A. Takeda,² T. Kobayashi.³
¹Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan; ²Nephrology, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan; ³Applied Immunology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
[Introduction]Acute antibody mediated rejection (AMR) has been a major problem in ABO-incompatible kidney transplantation (ABOi-KTx), and currently mycophenolate mofetil and rituximab have been used to…