Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function
A. Gilbert,¹ E. Hall,¹ O. Timofeeva,² M. Awwad,² M. Grafals,¹ P. Weems,¹ D. Li,² S. Rosen-Bronson,² J. Moore,¹ B. Javaid,¹ M. Cooper.¹
¹Department of Surgery, MedStar Georgetown Transplant Institute, Washington, DC; ²Department of Pathology, MedStar Georgetown Transplant Institute, Washington, DC.
Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…
2015 American Transplant Congress
Antibody-Mediated Rejection of Renal Allografts by CCR5-/- Mice Does Not Require CD8 T Cells
N. Kohei,¹ T. Tanaka,¹ H. Tsuda,¹ N. Dvorina,¹ K. Tanabe,² W. Baldwin,¹ R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Antibody-mediated acute and chronic graft injury remains a major cause of renal allograft loss. Mechanisms underlying these injuries remain unclear due in part to the…
2015 American Transplant Congress
Steroid Free Immunosuppression Protocol in Pediatric Kidney Transplant Recipients Using Alemtuzumab: A Retrospective Single Center Study
R. Shah,¹ Z. Kadry,¹ S. Wassner,² D. Kees-Folts,² M. Freeman,² P. Freeman,¹ B. Olenowski,¹ A. Jain.¹
¹Surgery, Hershey Medical Center, Hershey, PA; ²Pediatric Nephrology, Hershey Medical Center, Hershey, PA.
Background: Steroid free immunosuppression is attractive in pediatric kidney transplantation (KTx). Aim of the present study is to examine the patient survival, graft survival, rate…
2015 American Transplant Congress
Kidney Double Negative TCR αβ + Cells: Newly Described Intra-Renal Kidney Lymphocytes That Respond to Ischemia Reperfusion in Mice
M. Martina,¹ S. Bandapalle,² S. Noel,² A. Saxena,¹ A. Hamad,¹ H. Rabb.²
¹Pathology, Johns Hopkins University, Baltimore, MD; ²Medicine, Johns Hopkins University, Baltimore, MD.
Background TCRαβ+CD4-CD8- double negative (DN) T cells with immunoregulatory function are a significant component of T cells residing in the kidney. The exact role of…
2015 American Transplant Congress
Efficacy and Safety of Three Different Treatment Regimen in De Novo Renal Transplant Patients: Month 48 Follow-Up Results of the HERAKLES Trial
C. Sommerer,¹ K. Budde,¹ V. Kliem,¹ O. Witzke,¹ M. Guba,¹ J. Jacobi,¹ B. Vogt,³ I. Hauser,¹ P. Reinke,¹ R. Stahl,¹ T. Rath,¹ M. Porstner,² D. Baeumer,² M. Zeier,¹ W. Arns,¹ F. Lehner.¹
¹Herakles Study Group, Germany; ²Novartis Pharma, Nuremberg, Germany; ³Herakles Study Group, Switzerland.
Aim: To compare safety and efficacy of 3 different immunosuppressive (IS) regimen 4years after renal transplantation (Tx).Methods: 802 patients (pts) were included in this 1year,…
2015 American Transplant Congress
Effect of Patient Functional Status on the Associations Between Kidney Transplant Waitlisting, Race, and U.S. Region
L. Plantinga, R. Patzer, S. Pastan, C. Bowling.
Emory University, Atlanta.
Background: Black race and Southeastern residence at the start of end-stage renal disease (ESRD) are associated with reduced access to the U.S. kidney transplant waitlist,…
2015 American Transplant Congress
Impact of Abdominal Aortic Calcification in Living Kidney Donors
Y. Yoon,¹ K. Choi,² D. Joo,³ K. Huh,³ M. Kim,³ S. Kim,³ Y. Kim,³ S. Yang,² W. Han.¹
¹Department of Urology, Yonsei University College of Medicine, Seoul, Korea; ²Department of Urology, CHA University, Seongnam-si, Korea; ³Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea.
Introduction: To assess the association between abdominal aortic calcification (AAC) and renal function of living kidney donor and to evaluate the value of an AAC…
2015 American Transplant Congress
Gender Disparity in Infections After Kidney Transplantation
S. Bae, L. Kucirka, C. Durand, B. Orandi, R. Avery, D. Segev.
Johns Hopkins, Baltimore, MD.
BACKGROUND: Female gender has been suggested as a risk factor for infection after kidney transplant (KT). Preliminary studies have reported that sex hormones such as…
2015 American Transplant Congress
Deficiency of Naturally Occurring Anti-Angiogenic Antibodies Associate With the Development of Metastatic Cancer Post Renal Transplantation and Patient Death
R. Carroll,¹ A. Phillippe,² R. Catar,² H. Heidecke,² D. Dragun.²
¹Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia; ²Centre for Cardiovascular Research, Charite Hospital, Berlin, Germany.
We assessed the presence of naturally occurring blocking antibodies to mediators of vascularisation and metastasis in Kidney Transplant Recipients (KTR) with metastatic cancer (n=11), non…
2015 American Transplant Congress
Immunologic Outcomes in Elderly Kidney Transplant Recipients
D. Khadzhynov, F. Halleck, L. Liefeldt, P. Glander, J. Bamoulid, S. Kreimer, L. Lehner, K. Budde, O. Staeck.
Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.
BACKGROUND: Only few data are available about immunologic outcomes of elderly kidney transplant recipients (KTR).PATIENTS AND METHODS: This retrospective long-term observational study included all adult…