Articles tagged "Kidney transplantation"

2015 American Transplant Congress
A Cross-Organ Tissue Gene Expression Immune Signature Predates Chronicity
Y. Ng, O. Bestard, T. Sigdel, S.-C. Hsieh, T. Tran, M. Sarwal.
Transplantation Surgery, UC San Francisco, San Francisco, CA.
Purpose Meta-analysis of 796 microarrays led to the discovery of 11 over-expressed genes (BASP1, CD6, CXCL9, CXCL10, INPP5D, ISG20, LCK, NKG7, PSMB9, RUNX3, and TAP1)…
2015 American Transplant Congress
A Novel, Blocking Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B-Cell Depletion Or Thromboembolic Events
J. Rush,¹ G. Wieczorek,¹ M. Audet,² M. Schneider,¹ P. Espie,³ L. Roth,¹ C. Heusser,¹ C. Bruns,¹ D. Patel,¹ F. Cordoba.¹
¹Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland; ²Hôpital de Hautepierre, Strasbourg, France; ³Drug Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Background. CD40-CD154 pathway blockade prolongs renal allograft survival in non-human primates (NHPs). However, antibodies targeting CD154 were associated with an increased incidence of thromboembolic complications…
2015 American Transplant Congress
New SRTR Risk-Adjustment Models for Adult Kidney Transplant Outcomes
J. Snyder,¹ N. Salkowski,¹ D. Zaun,¹ H. Xiong,¹ S. Leppke,¹ B. Thompson,¹ D. Segev,^1,2 L. Hunsicker,¹ A. Israni,¹ B. Kasiske.¹
¹Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; ²Johns Hopkins University, Baltimore, MD.
Following a recommendation of the Consensus Conference on Transplant Program Quality and Surveillance, SRTR implemented a 3-year rolling cycle to rebuild the statistical models used…
2015 American Transplant Congress
Outcomes of ABO Incompatible Kidney Transplantation in Children
J. Stojanovic,¹ A. Adamusiak,² A. Waters,¹ D. Bockenhauer,¹ N. Kessaris,² C. Barton,³ H. Jones,³ J. Taylor,³ S. Marks,¹ N. Mamode.²
¹Department of Paediatric Nephrology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom; ²Department of Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; ³Department of Paediatric Nephrology, Evelina London Children's Hospital, London, United Kingdom.
Purpose: ABO blood group incompatible transplantation (ABOi) has become increasingly common over the last decade, in part due to a shortage of suitable deceased donor…
2015 American Transplant Congress
Distinct Blood and Biopsy Meta-Signatures for Acute Rejection Post Kidney Transplant
W. Zhang,¹ Z. Yi,¹ Z. Li,¹ M. Menon,¹ L. Li,¹ C. Xi,¹ I. Greene,¹ C. Wei,¹ L. Gallon,² M. Samaniego,³ A. Djamali,⁴ S. Alexander,⁵ B. Schroppel,¹ B. Nankivell,⁵ J. Chapman,⁵ I. Rosales,⁶ R. Neal Smith,⁶ R. Colvin,⁶ P. O'Connell,⁵ P. Heeger,¹ B. Murphy.¹
¹Icahn School of Medicine at Mount Sinai, New York; ²North Western University, Chicago; ³University of Michigan, Michigan; ⁴University of Wisconsin, Madison; ⁵The University of Sydney, Sydney, Austria; ⁶Massachusetts General Hospital, Boston.
Acute rejection (AR) is a major cause of allograft dysfunction. Molecular signatures of AR from blood and biopsy have been identified by several independent cohort…
2015 American Transplant Congress
Metrics of Global Health Status Signal Early Hospital Readmission Risk After Kidney Transplantation
M. Harhay,¹ A. Hill,² W. Wang,² O. Even-Shoshan,² A. Mussell,¹ J. Karlawish,³ R. Bloom,¹ H. Feldman,¹ J. Silber,² P. Reese.¹
¹Medicine, Division of Nephrology, University of Pennsylvania, Philadelphia, PA; ²Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; ³Medicine, Division of Geriatrics, University of Pennsylvania, Philadelphia, PA.
Background: Early (≤30 days) hospital readmission (EHR) after kidney transplantation (KT) is common, with diverse causes that likely include poor pre-KT health status. Transplant providers…
2015 American Transplant Congress
Economic Analysis of Kidney Transplant Tolerance: The Holy Grail Is Less Costly
N. Elias, S. Shao, T. Gift, B. Patel, A. Cosimi, T. Kawai.
Transplant Surgery, Massachusetts General Hospital, Boston, MA.
Introduction: Kidney transplantation (KTx), although expensive, is a more cost effective treatment for end-stage renal disease (ESRD) than dialysis, and provides better long term survival…
2015 American Transplant Congress
Kidney Transplantation Using Kidneys from Donation After Circulatory Death Donors: Results from the UK Experience
D. Summers,^1,2,3 R. Johnson,² D. Collett,² C. Watson,^1,3 J. Neuberger,² G. Pettigrew,^1,3 J. Bradley.^1,3
¹Department of Surgery, Cambridge University, Cambridge, United Kingdom; ²Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom; ³Cambridge NIHR Biomedical Reseach Centre, Cambridge, United Kingdom.
Introduction: Kidneys from donation after circulatory-death donors currently make up over 40% of deceased donor kidney transplants in the UK. In addition, 34% of deceased…
2015 American Transplant Congress
Designing a KDPI to Assess Live Donors and Compare Them to Deceased Donors
A. Massie, D. Segev.
Johns Hopkins, Baltimore.
The Kidney Donor Profile Index (KDPI) is used to assess risk of deceased donor kidneys (DDKT) based on donor characteristics. No comparable index exists for…
2015 American Transplant Congress
Pregnancy Outcomes in Kidney Recipients With Longer Transplant to Conception Intervals
S. Constantinescu,^1,2 L. Coscia,² D. Armenti,² P. Axelrod,¹ M. Ghanta,¹ S. Rao,¹ M. Moritz.^2,3
¹Temple University School of Medicine, Philadelphia; ²National Transplantation Pregnancy Registry, Gift of Life Institute, Philadelphia; ³Lehigh Valley Heath Network, Allentown.
The purpose of this study was to analyze pregnancy outcomes in female kidney transplant recipients with transplant to conception intervals (TCI) after the recommended 2…