Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.
A. Haririan,¹ M. Chaudhry,² J. Papadimitriou,² N. Costa,¹ B. Thomas,¹ M. Mavanur,¹ R. Ugarte,¹ C. Cangro,¹ C. Drachenberg.²
¹Dept of Medicine, Unniversity of Maryland, Baltimore, MD; ²Dept of Pathology, University of Maryland, Baltimore, MD.
The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…
2016 American Transplant Congress
CD57+ CD4 T Cells Persist in the Periphery Following Kidney Transplantation.
J. Espinosa,^1,2 L. Stempora,¹ R. Townsend,³ A. Kirk.¹
¹Duke University, Durham; ²Emory University, Atlanta; ³Bristol-Meyers Squibb, Princeton.
Purpose: We have shown that CD57+PD1- CD4 T cells play a role in belatacept-resistant rejection, but their mechanism of action is incompletely defined. Potential mechanisms…
2016 American Transplant Congress
Informing Informed Consent for High KDPI Kidneys.
A. Nishio Lucar, D. Keith, G. Vranic.
Medicine, University of Virginia, Charlottesville, VA.
The standard approach to informed consent for high KDPI (KDPI 86-100%) deceased donor kidneys (DDK) relies on anticipated graft half-life and may not provide candidates…
2016 American Transplant Congress
Eary Use of Statins Associated with Improved Death-Censored Graft Survival Following Kidney Transplant.
T. Horwedel,¹ D. Brennan,² K. Lentine,³ J. Hagopian.¹
¹Barnes-Jewish Hospiptal, St. Louis, MO; ²Washington University School of Medicine, St. Louis, MO; ³St. Louis University, MO.
Purpose: The impacts of statin therapy on patient and graft outcomes after kidney transplantation (KT) are controversial.Methods: We performed a retrospective cohort study of adult…
2016 American Transplant Congress
Calcineurin Inhibitors Promote Metastasis in Post-Transplant Colorectal Cancer Through Cancer Related- Exosomes Released from Cancer Cells in TGF Beta Independent Epitheilal to Mesenquimal Transition.
V. Tubita,¹ J. Segui-Barber,⁴ M.-J. Ramírez-Bajo,¹ D. Moya-Rull,¹ P. Piselli,³ D. Verdirosi,³ F. Oppenheimer,^1,2,5 D. Serraino,⁶ H. Del Portillo,^4,7 F. Diekmann,^1,2,5 J. Campistol,^1,2,5 I. Revuelta.^1,2,5
¹Experimental Laboratory of Nephrology and Kidney Transplant, IDIBAPS, Barcelona, Spain; ²Department of Nephrology and Kidney Transplant, Hospital Clínic, Barcelona, Spain; ³Dipartamento di Epidemiologia e Ricerca Pre-Clinica, INMI “L. Spallanzani” IRCCC, Rome, Italy; ⁴ISGlobal, CRESIB, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; ⁵National Network for Kidney Research (REDinREN), Carlos III Royal Institute, Ministry of Health, Madrid, Spain; ⁶IRCCS Centro di Riferimento Oncologico, Aviano, Italy; ⁷Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Introduction: Cancer is one of the major causes of death in kidney transplantation. Despite more mortality in colon cancer (CRC), similar incidence than general population…
2016 American Transplant Congress
Comparison of Renal Outcomes Between ABO-Incompatible and Kidney Paired Donation Transplantation In Living Donors.
N. Hashemi, M. Tavakol, B. Lee.
Kidney Transplant Unit, UCSF, San Francisco, CA.
Introduction: ABO incompatible transplantation (ABOi Tx) broadens the donor pool and decreases wait times for patients who don't have a blood type compatible living kidney…
2016 American Transplant Congress
Clinical Impact of Pre-Transplant Serum 25-Hydroxyvitamin D Levels on the Post-Transplant Immunologic and Non-Immunologic Outcomes in Kidney Transplant Recipients.
T. Ban,^1,2 J. Kim,^1,2 Y. Lee,¹ B. Choi,^1,2 C. Park,^1,2 C. Yang,^1,2 Y.-S. Kim,^1,2 B. Chung.^1,2
¹Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea; ²Transplant Research Center, Seoul St. Mary's Hospital, Seoul, Korea.
Background: The aim of this study is to investigate the clinical significance of pre-transplant serum 25-hydroxyvitamin D (25(OH)D) levels in regard to post-transplant clinical outcome…
2016 American Transplant Congress
Analysis of T Cell Receptor Repertoire in Routine Renal Allograft Biopsy.
R. Reindl-Schwaighofer,¹ J. Weinberger,¹ R. Jimenez-Heredia,¹ J. Sunzenauer,¹ S. Schaller,² S. Winkler,² R. Oberbauer.¹
¹Department of Nephrology, Medical University of Vienna, Vienna, Austria; ²Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg, Austria.
Introduction: Diversity and clonality of the T cell repertoire of circulating and tissue-resident T-cells can be assessed by sequencing of recombined T cell receptor (TCR)…
2016 American Transplant Congress
Impaired Outcome of Kidney Transplants from Donors with Acute Kidney Injury.
K. Schuette-Nuetgen,¹ G. Thölking,¹ H. Pavenstädt,¹ S. Ehlert,¹ B. Suwelack,¹ D. Palmes,² R. Bahde,² S. Reuter.¹
¹Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, Muenster, Germany; ²Department of General and Visceral Surgery, University Hospital of Muenster, Muenster, Germany.
Given the gap between patients in need of a kidney transplantation and organs available, transplantation centers increasingly accept lower quality organs, e.g. from donors with…
2016 American Transplant Congress
Clinical Outcome on Kidney Retransplantation in Comparison with First Kidney Transplantation in Korea – Nationwide Cohort Study.
J. Kim,^1,2 T. Ban,^1,2 B. Jung,^1,2 B. Choi,^1,2 C. Park,^1,2 C. Yang,^1,2 Y.-S. Kim.^1,2
¹Transplantation Research Center, Seoul St. Mary's Hospital, Seoul, Republic of Korea; ²Internal Medicine, Seoul St. Mary's Hospital, Seoul, Republic of Korea.
Due to the limitation of the survival of kidney allograft, increasing number of patients need to take re-transplantation (re-KT) after the first allograft failure. In…