Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Alloimmunity Through Non-HLA Epitopes in Kidney Transplantation.
R. Reindl-Schwaighofer,¹ A. Kainz,¹ B. Cole,² J. van Setten,² K. Jelencsics,¹ B. Keating,² R. Oberbauer.¹
¹Department of Nephrology, Medical University of Vienna, Vienna, Austria; ²Transplant Division, University of Pennsylvania, Philadelphia, PA.
Introduction: An unexpected diversity in the human genome has been identified including more than 2,500 nonsynonymous single nucleotide polymorphisms (nsSNP) and up to 20 homozygous…
2016 American Transplant Congress
Risk Factors for Clinical Urinary Tract Infections in Kidney Transplant Recipients with Asymptomatic Bacteriuria.
S. Medani, M. Dorais, A. Tavares-Brum, H. Mawad, A. Duclos, C. Lemieux, A. Barama, H. Cardinal.
Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
BackgroundThere is no clear consensus on whether asymptomatic bacteriuria (ABU) should be treated in kidney transplant recipients (KTRs). We sought to identify patient or episode…
2016 American Transplant Congress
Preservation of Alloreactive and Antiviral Immunity After Switch to Belatacept-Based Regimen After Kidney Transplantation.
J. Schaenman,¹ Y. Korin,² T. Sidwell,² V. Groysberg,² J. Gadzhyan,¹ E. Lum,¹ U. Reddy,¹ E. Huang,¹ T. Pham,¹ G. Danovitch,¹ E. Reed,² S. Bunnapradist.¹
¹Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Purpose: We set out to investigate the impact of switch from calcineurin inhibitor (CNI) to belatacept on T cell mediated allo- and EBV-specific immunity.Methods: We…
2016 American Transplant Congress
Differences in Reported Barriers to Immunosuppression Adherence Among a Cohort of Pediatric Renal Transplant Recipients from the United States and Canada.
O. Bignall II,^1,2 A. Pai,² S. Amaral,³ S. Furth,³ N. Bergman,² J. Goebel,⁴ The TAKE-IT Study Investigators, B. Foster.⁵
¹Nephrology and Hypertension, Cincinnati Children's Hospital, Cincinnati, OH; ²Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital, Cincinnati, OH; ³Nephrology, The Children's Hospital of Philadelphia, Philadelphia, PA; ⁴Nephrology, Children's Hospital of Colorado, Aurora, CO; ⁵Nephrology, Montreal Children's Hospital, Montreal, QC, Canada.
Aim: The purpose of this study was to examine differences in reported barriers to immunosuppressant adherence (IA) between a cohort of pediatric renal transplant recipients…
2016 American Transplant Congress
Evaluation of Polyomavirus (BK) Treatment and Clinical Outcomes in Pediatric Kidney Transplant Recipients: A >10 Year Single Center Retrospective Experience.
R. Liverman,¹ E. Kraus,¹ R. Garro,² B. Warshaw,² P. Winterberg,² R. George.²
¹Children's Healthcare of Atlanta, Atlanta, GA; ²Division of Pediatric Nephrology, Emory University School of Medicine, Atlanta, GA.
BK viremia (BKV) is a serious infectious complication after kidney transplantation and can lead to BK nephropathy (BKN) and allograft loss. We reviewed our experience…
2016 American Transplant Congress
Urinary Tract Infections During the First Year After Renal Transplantation: Risk Factors and Nomograms.
C. Jironda, V. López, M. Cabello, A. Duarte, C. Gutiérrez, P. Ruiz, D. Burgos, D. Hernández.
Nephrology, Regional University Hospital, Málaga, Spain.
Background: Urinary tracts infections (UTIs) are the most common infectious complications following renal transplantation (RT). The aim of this study was to evaluate the frequency…
2016 American Transplant Congress
Pregnancy in the Renal Transplant Recipient: Pregnancy Viability and Effects on Graft Function.
A. Lima, M. Cristelli, C. Teixeira, I. Pietrobom, G. Basso, L. Viana, M. de Paula, C. C[acirc]ndido, H. Tedesco-Silva, J. Pestana.
Nephrology, Hospital do Rim, São Paulo, Brazil.
Background: Fertility in women is recovered few months after kidney transplantation. However, pregnancy viability and maternal complications remain uncertain. Methods: We studied data of patients…
2016 American Transplant Congress
Accepted Mouse Kidney Allografts Are Characterized by Widespread Nitrosylation.
I. Aljabban, B. Jiang, C. Yang, D. Ndishabandi, R. White, P. Russell, J. Madsen, R. Colvin, A. Alessandrini.
Center for Transplantation Sciences, Dept. of Surgery, Dept. of Pathology, Massachusetts General Hospital, Boston, MA.
Leukocytes can modulate the immune response through manipulation of amino acid metabolism. Research indicates that depletion of L-arginine and generation of nitric oxide (NO) suppresses…
2016 American Transplant Congress
BK Nephropathy, but Not Isolated BK Viremia Associated with De Novo DSA Despite Similar Immunosuppression Reduction.
W. Cheungpasitporn,¹ D. Mitema,¹ H. Amer,¹ F. Cosio,¹ M. Stegall,² C. Schinstock.¹
¹Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²Transplantation Surgery, Mayo Clinic, Rochester, MN.
Introduction: Reduced immunosuppression is associated with de novo DSA (dn DSA). Although immunosuppression is often reduced in patients with polyomavirus (BK), the incidence of dn…
2016 American Transplant Congress
High-Risk Pharmacogenetic (PGx) Variants in Kidney Transplant (tx) Recipients.
D. Berglund,¹ D. Schladt,² K. Sanghavi,¹ W. Guan,¹ B. Wu,¹ C. Dorr,³ R. Remmel,¹ R. Mannon,⁴ A. Matas,¹ W. Oetting,¹ A. Israni,³ P. Jacobson,¹ DeKAF Genomics Investigators.
¹UofMN, Mpls; ²MMRF, Mpls; ³HCMC, Mpls; ⁴UAB, Birmingham.
Kidney tx recipients carry a high burden of comorbidities, and some of the medications for these conditions have genetic predictors of efficacy and toxicity. These…