Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation.
L. Gallon,¹ J. Leventhal,¹ C. Dumur,² J. Mathew,¹ L. Nadimpalli,¹ A. Shetty,¹ S. Ildstad,³ V. Mas.²
¹Medicine/Nephrology, Northwestern University, Chicago, IL; ²Medicine/Nephology, University of Virginia Health System, Charlottesville, VA; ³Immunology, University of Louisville, Louisville, KT.
Organ transplantation relies upon nonspecific immunosuppressive (IS) agents to prevent graft rejection. However, IS drugs have significant toxicities and chronic rejection occurs despite their usage.…
2016 American Transplant Congress
Storage Kidneys Prior to Transplantation Using First Polish Preservation Solution "Biolasol" – Preliminary Report.
A. Jozwik,¹ P. Domagala,¹ R. Kieszek,¹ M. Wszola,¹ M. Bieniasz,¹ M. Serwanska-Swietek,¹ M. Durlik,² F. Ryszka,³ A. Chmura,¹ A. Kwiatkowski.¹
¹Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; ²Departments of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland; ³BIOCHEFA, Sosnowiec, Poland.
One of the factors affecting function of the transplanted organ is a method of its storage. The aim of the study is to evaluate the…
2016 American Transplant Congress
Impact of Everolimus and Low-Dose Ciclosporin on Cytomegalovirus Replication and Disease in Pediatric Renal Transplantation.
B. Höcker,¹ S. Zencke,¹ L. Pape,² K. Krupka,¹ L. Kösters,¹ A. Fichtner,¹ L. Dello Strologo,² I. Guzzo,² R. Topaloglu,² B. Kranz,² J. König,² M. Bald,² N. Webb,² A. Noyan,² H. Dursun,² S. Marks,² Z. Ozcakar,² F. Thiel,² H. Billing,² M. Pohl,² H. Fehrenbach,² P. Schnitzler,¹ T. Bruckner,¹ L. Weber,² R. Feneberg,² T. Ahlenstiehl-Grunow,² B. Tönshoff.¹
¹University Children's Hospital, Heidelberg, Germany; ²Certain Research Community, Germany, Italy, Turkey, United Kingdom.
Purpose: Preclinical studies indicate an anti-cytomegalovirus (CMV) activity of the mammalian target of rapamycin inhibitor (mTORi) everolimus (EVR), but data in pediatric renal transplant recipients…
2016 American Transplant Congress
Optimal Integration of Kidney Exchange Programs with Antibody Reduction Therapy to Increase Successful Transplant in Difficult to Match Recipients.
K. Melancon,¹ N. Koizumi,² M. Gentili,³ C. Callender.⁴
¹Surgery, George Washington University Hospital, Washington, DC; ²Public Policy, George Mason Univ, Arlington, VA; ³Operations Research, University of Louisville, Louisville, KY; ⁴Surgery, Howard University Hospital, Washington, DC.
Kidney paired donation (KPD) allows incompatible pairs to exchange kidneys with other incompatible pairs. However, evidence suggests there stills exist barriers to KPD utilization, especially…
2016 American Transplant Congress
Graft Loss Due to Recurrence of Focal Segmental Glomerulosclerosis in Second Renal Transplant.
V. Aggarwal, A. Gruessner, R. Gruessner, V. Whittaker, S. Narsipur.
Transplant, Upstate Medical University, Syracuse, NY.
Introduction : Focal segmental glomerular sclerosis (FSGS) glomerulonephritis can recur in renal transplants, and can potentially lead to graft loss. The rate of graft loss…
2016 American Transplant Congress
Give One and Done? Evaluating a Change in Surgical Prophylaxis in Kidney Transplant Recipients.
K. Bliven, C. Truax, K. Snow, N. Kenyon, A. Carlson, S. Yeager, L. Smith.
Pharmacy, University of Utah Hospital and Clinics, Salt Lake City, UT.
Surgical-site infections (SSIs) occur in up to 11% of kidney transplant (txp) patients (pts). There is no consensus on the optimal peri-op prophylaxis regimen for…
2016 American Transplant Congress
Anti-Thymocyte Globulin Induced Thrombocytopenia and Bleeding After Kidney Transplantation.
M. Dokus,¹ A. Patel,¹ J. Iuppa,² E. Venniro,³ A. Danzig,¹ J. Cooley,² J. Taylor,³ R. Kashyap,¹ M. Orloff.¹
¹Department of Surgery, Division of Transplant and Hepatobiliary Surgery, University of Rochester, Rochester, NY; ²Department of Pharmacy, University of Rochester, Rochester, NY; ³Department of Medicine, Division of Nephrology, University of Rochester, Rochester, NY.
Background: Bleeding is a significant challenge after renal transplantation. Anti-thymocyte globulin (ATG) induced thrombocytopenia may increase bleeding after kidney transplantation (KTx), but this association has…
2016 American Transplant Congress
The UK ONE Study: Safety and Feasibility of Regulatory T Cell Therapy in Renal Transplantation.
A. Bushell,¹ J. van der Net,^1,2 D. Game,³ R. Hilton,³ S. Thirkell,⁴ P. Friend,² E. Geissler,⁵ K. Wood,¹ P. Harden,² G. Lombardi.⁴
¹Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford, United Kingdom; ³Guy's Hospital, London, United Kingdom; ⁴Immunoregulation Laboratory, King's College London, Guy's Hospital, London, United Kingdom; ⁵Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
Introduction: The UK ONE Study trial investigates the safety and feasibility of regulatory T (Treg) cell therapy in renal transplantation.Materials and Methods: Eleven (9m;2f) living…
2016 American Transplant Congress
Understanding the Drivers Behind an Early Post-KAS Rise in Delayed Graft Function (DGF) Rates.
D. Stewart, A. Kucheryavaya, D. Klassen.
UNOS, Richmond, VA.
Background: DGF among solitary deceased donor kidney transplants (tx) increased by 22% (p<0.0001) -- from 24.6% to 30.1% -- during the first 6 months of…
2016 American Transplant Congress
Early Hospital Readmission Following Kidney Re-Transplantation.
E. King, B. Orandi, S. Bae, X. Luo, D. Segev.
Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
BACKGROUND: Among first time kideny transplant (KT) recipients the incidence of early hospital readmission (EHR) is 31%. Kidney re-transplants are more complex and we hypothesize…