Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Effect of Inflammation on Concentration of Intracellular Tacrolimus.
E. Bae,¹ S. Yang,² S. Han,¹ J.-Y. Park,¹ H. Lee,¹ Y. Kim.¹
¹Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; ²Kidney Research Institute, Seoul National University, Seoul, Republic of Korea.
Background: The use of calcineurin inhibitors improved the outcome for transplant recipients. However, acute rejection (AR) and infection remained still an unsolved problem. We evaluated…
2016 American Transplant Congress
Delays in the Live Kidney Donor Evaluation Process.
J. Leanza, K. Kumar, J. Tonascia, E. King, A. Massie, D. Segev.
JHU, Baltimore.
One of the barriers to live kidney donation (LKD) is successful completion of the evaluation process. While it is known that many potential donors (PDs)…
2016 American Transplant Congress
Surveillance Renal Allograft Biopsies Prognosticate Graft Function.
J. Thompson, D. Taber, P. Baliga, K. Chavin, T. Srinivas.
MUSC, Charleston, SC.
Background: Surveillance biopsy of the renal allograft provides a window into the health of the allograft and could allow prognostication of function by affording better…
2016 American Transplant Congress
“Day 2 Discharge” After Kidney Transplantation: Complications, Health Care Utilization, and Long-Term Clinical Outcomes.
A. Mathur, N. Katariya, A. Welu, J. Chang, R. Heilman, A. Singer, H. Khamash, H. Chakkera, W. Hewitt, D. Haakinson, M. Maningo-Salinas, E. Oakley, A. Moss, K. Reddy.
Transplant Center, Mayo Clinic, Phoenix.
Background: Reducing kidney transplant length of stay is a priority for many stakeholders. We aimed to determine whether very early discharge – on or before…
2016 American Transplant Congress
Clonal Expansion of Donor-Specific Tregs Following Combined Kidney and Bone Marrow Transplantation.
T. Savage,¹ S. Dewolf,¹ A. Obradovic,¹ S. Lau,¹ J. Zuber,¹ L. Turka,^2,3 Y. Shen,¹ M. Sykes.¹
¹Columbia University, New York; ²Massachusetts General Hospital, Boston; ³Immune Tolerance Network, Boston.
HLA-mismatched allograft tolerance was intentionally induced via combined kidney and bone marrow transplant (CKBMT) in two ITN protocols (NKDO3 and ITN036ST), but the mechanisms of…
2016 American Transplant Congress
NK-Activating MCMV Strain Is Associated with Increased Murine Renal Transplant Injury.
M. Shimamura,¹ M. Li,² B. Chen,² J. George,² T. Schoeb.³
¹Vaccines and Immunity, Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH; ²Pediatric Infectious Diseases, Cardiothoracic Surgery, Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Pathology and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Background: CMV contributes to inferior longterm kidney transplant survival. In a murine model, NK cells infiltrate MCMV infected renal allografts in greater numbers than in…
2016 American Transplant Congress
Have We Gone Too Far Defining Performance Outliers? One-Third of Kidney Transplant Programs Now Identified for Low Performance within Three Years.
J. Schold,¹ C. Miller,¹ M. Henry,² L. Buccini,¹ S. Flechner,¹ D. Goldfarb,¹ E. Poggio,¹ K. Andreonni.³
¹Cleveland Clinic, Cleveland, OH; ²Ohio State University, Columbus, OH; ³University of Florida, Gainesville, FL.
Transplant center report cards developed by SRTR are publicly available and utilized for regulatory oversight and insurance contracting. There are significant associations of performance oversight…
2016 American Transplant Congress
Serum Bicarbonate and Long-Term Outcomes in Kidney Transplant Recipients.
S. Park,¹ E. Kang,¹ M. Han,¹ J. Park,¹ S. Yang,² S. Park,³ I. Jung,⁴ C. Lim,⁵ Y. Kim,¹ Y. Kim,⁶ J. Lee.⁵
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ²Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea; ⁴Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea; ⁵Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; ⁶Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.
Background: Metabolic acidosis indicated by low serum bicarbonate (TCO2) level has been known as a risk factor for mortality and progressive renal dysfunction in patients…
2016 American Transplant Congress
Utilization of HCV-Positive Donors' Kidneys: Potential Benefits in the Era of Direct Acting Antiviral (DAA) Therapy.
B. Amundsen,¹ M. Sise,² M. Lin,³ H. Deirawan,¹ E. Heher,² B. Kimball,¹ J. Markmann,¹ N. Elias.¹
¹Massachusetts General Hospital, Boston, MA; ²Massachusetts General Hospital, Boston, MA; ³Brigham and Women's Hospital, Boston, MA.
Organ shortage and expanding kidney waiting list fostered utilization of HCV positive donors' organs (HCVD+). HCVD+ kidneys have slightly worse long term outcomes compared with…
2016 American Transplant Congress
Optimal Donor/Recipient Pairing for High KDPI Grafts Can Yield Similar Survival to Medium KDPI Grafts.
M. Selim, E. Saad, M. Zimmerman, C. Johnson.
Medical College of Wisconsin, Milwaukee.
KDPI is a predictor of deceased-donor (DD) graft survival, calculated using donor factors. It does not consider recipient or other post-procurement factors. This retrospective analysis…