Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Evaluation of T Cell Immunity in Elderly Solid Organ Transplant Recipients.
J. Schaenman,¹ Y. Korin,² T. Sidwell,² V. Groysberg,² E. Lum,¹ E. Huang,¹ S. Bunnapradist,¹ T. Pham,¹ G. Danovitch,¹ E. Reed.²
¹Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Elderly transplant recipients experience increased rates of death, especially death due to infection, as compared with younger patients. However, little is known about the mechanism…
2016 American Transplant Congress
Assessment of mRNA Gene Profiles in Plasma Exosome to Predict Risk for Antibody-Mediated Rejection (ABMR) of Renal Allografts.
H. Zhang,¹ J. Kahwaji,¹ P. Li,² S. Ge,¹ D. Thomas,¹ C. Nast,³ A. Vo,¹ M. Haas,³ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ³Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: ABMR is a major obstacle for successful transplant in HLA-sensitized (HS) patients. Complement-mediated and antibody-dependent cellular cytotoxicity (ADCC) are primarily mechanisms for ABMR. Previously…
2016 American Transplant Congress
The Early Outcomes of Bortezomib Therapy in Patients with Late Antibody Mediated Rejection in Renal Transplantation.
J. Choi, J. Jung, S. Shin, Y. Kim, D. Han.
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Although several strategies for treating antibody mediated rejection (AMR) in renal transplants have been investigated, the formation of donor-specific antibodies (DSA) and ongoing AMR contribute…
2016 American Transplant Congress
Analysis of a Large Single-Center Cohort of Renal Transplant Recipients with Histoplasmosis.
M. Mashayekhi, A. Langone.
Internal Medicine, Vanderbilt University Medical Center, Nashville, TN.
The dimorphic fungus Histoplasma capsulatum is endemic along the Ohio and Mississippi River Valleys and can cause clinically significant disease in those with impaired cellular…
2016 American Transplant Congress
Outcomes in Black vs Non-Black Patients Administered Belatacept (Bela) or Cyclosporine (CsA) in BENEFIT.
F. Vincenti,¹ J. Medina Pestana,² M. Abouljoud,³ B. Bresnahan,⁴ V. Duro Garcia,⁵ L. Mulloy,⁶ K. Rice,⁷ L. Rostaing,⁸ C. Zayas,⁹ K. Calderon,¹⁰ U. Meier-Kriesche,¹⁰ M. Polinsky,¹⁰ H. Zhao,¹⁰ C. Larsen.¹¹
¹UCSF, San Francisco; ²Hosp do Rim, Sao Paulo, Brazil; ³Henry Ford Hosp, Detroit; ⁴Med Coll of Wisconsin, Milwaukee; ⁵Hospital Dom Vicente Scherer, Porto Alegre, Brazil; ⁶Georgia Regents Univ, Augusta; ⁷Baylor Univ Med Ctr, Dallas; ⁸Univ Hosp and INSERM U563, IFR-BMT, Toulouse, France; ⁹Piedmont Hosp, Atlanta; ¹⁰BMS, Lawrenceville; ¹¹Emory Univ Transplant Center, Atlanta.
Studies consistently show worse outcomes for black vs non-black kidney transplant recipients. At 7 yrs post-transplant in BENEFIT, bela was associated with superior graft survival…
2016 American Transplant Congress
Unexpected Early Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.
M. Yanik,¹ R. Mannon,² M. Seifert.¹
¹Pediatrics, University of Alabama at Birmingham, Birmingham, AL; ²Medicine, University of Alabama at Birmingham, Birmingham, AL.
Background: Calcineurin inhibitors effectively suppress the recipient immune response and facilitate early success in kidney transplantation. However, these drugs are potent nephrotoxins and contribute to…
2016 American Transplant Congress
Simultaneous Pancreas/Kidney Transplantation Increases the Risk of Late-Onset BKV-Associated Nephropathy.
T. Schachtner,^1,2 M. Zaks,¹ A. Kahl,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
Infections have increased in simultaneous pancreas/kidney transplant recipients (SPKTRs) with BKV-associated nephropathy (BKVN) being the most important infectious cause of allograft loss. Comparisons of BKVN…
2016 American Transplant Congress
Is CMV Prophylaxis Effective in CMV-Seropositive Patients Receiving Thymoglobulin as Induction Therapy?
E. Feitosa, F. Agena, J. Reusing Jr, F. Lemos, E. David-Neto.
Kidney Transplantation Service, Hospital das Clinicas - University of Sao Paulo, Sao Paulo, Brazil.
Thymoglobulin (ATG) used as induction therapy is considered a risk factor for CMV disease in renal transplantation (RTx) and prophylaxis is recommended. Our center policy…
2016 American Transplant Congress
Association of Genetic Polymorphisms of Angiopoietin-Like 4 with Proteinuria in Kidney Allograft Recipients.
Y. Chang,^1,4 T. Shah,^2,4 Y.-T. Chuang,³ D. Min.⁴
¹Mendez National Institute of Transplantation Foundation, Los Angeles, CA; ²St. Vincent Medical Center, Los Angeles, CA; ³Taipei medical university, Taipei, Taiwan; ⁴Western University of Health Sciences, Pomona.
Background: Proteinuria is a hallmark of glomerular injury, and persistent proteinuria is associated with graft failure in kidney transplant patients. Recently, it is known that…
2016 American Transplant Congress
Potential Biomarkers and Treatment for BK Virus Associated Nephropathy.
M. Borkar,¹ V. Srivastava,² R. Cunnington,¹ T. Sharma,¹ L. Tibbles.¹
¹Faculty of Mediicne, University of Calgary, Calgary, AB, Canada; ²CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India.
Background: BK polyomavirus assoiciated nephropathy (BKVAN) is one of the major complications in renal transplants, and is associated with significant fibrosis It is important to…