Articles tagged "Kidney transplantation"

2017 American Transplant Congress
DNA Hypermethylation Caused by Ischemia in Kidney Transplants Predicts Future Chronic Injury to the Allograft.
L. Heylen,^1,2,3,4 B. Thienpont,^3,4 M. Naesens,^1,2 J. Depreeuw,^3,4 P. Busschaert,^3,4 D. Kuypers,^1,2 I. Jochmans,^2,5 D. Monbaliu,^2,5 J. Pirenne,^2,5 D. Lambrechts,^3,4 B. Sprangers.^1,2
¹Nephrology, University Hospitals Leuven, Leuven, Belgium; ²Microbiology and Immunology, KU Leuven, Leuven, Belgium; ³Oncology, KU Leuven, Leuven, Belgium; ⁴VIB, Leuven, Belgium; ⁵Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Study Purpose: DNA demethylation results from hydroxymethylation and is inhibited by hypoxia. We investigated whether ischemia during kidney transplantation induces DNA methylation changes of the…
2017 American Transplant Congress
De Novo Donor-Specific Antibody Formation After Kidney Retransplant Is Associated with Specificity Against Class I.
K. Atiemo,¹ B. Ho,¹ H. Bhagat,² E. Lee,^2,3 A. Daud,¹ R. Kang,¹ S. Montag,^1,4 L. Zhao,^1,4 J. Schwartz,² D. Ladner.¹
¹Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; ²Astellas Pharma Global Development, Northbrook; ³Now with UCB, Atlanta; ⁴Dept of Preventive Medicine, Northwestern University, Chicago
Retransplant (RTx) patients are often sensitized due to donor-specific antibody (DSA) formation, with higher acute rejection rates during subsequent transplants vs patients without DSA. However,…
2017 American Transplant Congress
Renal Transplant Patient Outcomes Following Plasmapheresis, Thymoglobulin, and Rituximab Induction for High Risk DSA Positive Recipients.
E. Lessmann,¹ M. Moaddab,¹ M. Manson,¹ A. Ram,² R. Kerman,² P. Jindra.²
¹Pharmacy, CHI St. Luke's Health Baylor St. Luke's Medical Center, Houston, TX; ²Immune Evaluation Laboratory, Baylor College of Medicine, Houston, TX
Background: Kidney transplantation is associated with improved survival and quality of life relative to dialysis for patients with end-stage renal disease (ESRD). Patients who are…
2017 American Transplant Congress
Prevention of Donor Specific Antibody Production After Skin Allografting by Mobilization of Endogenous Stem Cells Using a Combination of AMD3100 and Low-Dose FK506 in Rats.
A. Ahmadi,¹ L. Qi,¹ R. Wesson,¹ F. Dor,² J. Burdik,¹ B. Philosophe,¹ G. Williams,¹ A. Cameron,¹ Z. Sun.¹
¹Dept. of Surgery, Johns Hopkins University, Baltimore, MD; ²Dept. of Surgery, Imperial College Healthcare, London, United Kingdom
Background: We have developed a stem cell mobilizing strategy that enables long-term liver and kidney allograft survival without sustained immunosuppression in small and large animals…
2017 American Transplant Congress
Three Induction Therapies on Patients with Delayed Graft Function After Kidney Transplantation, a Three-Year Outcome Analysis.
A. Umber, M. Killackey, A. Paramesh, B. Alper, F. Teran, A. Baudy, Y. Liu, J. Buell, R. Zhang.
Departments of Medicine and Surgery, Tulane University School of Medicine, New Orleans, LA
We compare the 3-year outcomes of induction therapies with either methylprednisolone (group 1, n=58), basiliximab (group 2, n=56) or alemtuzumab (group 3, n=98) in primary…
2017 American Transplant Congress
Can We Improve Donation Through Pre-Kidney Transplantation Education Using Internet-Based Resources? An Analysis of Internet Use Patterns Among Hispanics.
H. Gomez, E. Malagon-Blackwell, J. Caicedo.
The Comprehensive Transplantation Center, Northwestern University Feinberg School of Medicine, Chicago, IL
Context: Waitlisted Hispanics received disproportionately fewer living donor kidney transplantation in 2014 compared to non-Hispanic whites (4% versus 10%). Internet-based education improves organ donation and…
2017 American Transplant Congress
Discrepancies in Perceived and Measured Cognitive Abilities in Transplant Recipients.
A. Gupta,¹ J. Mahanken,² J. Klein,¹ D. Johnson,³ J. Burns.⁴
¹Nephrology, University of Kansas Medical Center, Kansas City, KS; ²Biostatistics, University of Kansas Medical Center, Kansas City, KS; ³Psychology, University of Kansas, Lawrence, KS; ⁴Neurology, University of Kansas Medical Center, Kansas City
Aim: Examine how perceived cognitive performance compares with measured cognitive performance in renal transplant recipients.Background: Cognitive abilities affect patients' complex post-transplant care. An accurate assessment…
2017 American Transplant Congress
Psychosocial Distress in Chronic Kidney Disease: Benefits of Kidney Transplantation.
C. Richardson,¹ D. Belenko,¹ E. Mucsi,¹ N. Edwards,¹ D. Wong,¹ M. Novak,² M. Li,³ I. Mucsi.¹
¹Multiorgan Transplant Program, University Health Network, Toronto, ON, Canada; ²Department of Psychiatry, University Health Network, Toronto, ON, Canada; ³Department of Psychosocial Oncology and Palliative Care, Princess Margaret Hospital, Toronto, ON, Canada
PurposeWe describe the frequency of psychosocial distress among Canadian patients with advanced chronic kidney disease (CKD), and compare distress between pre-dialysis, dialysis patients and kidney…
2017 American Transplant Congress
Impact of Early Pancreas Graft Failure on Patient and Kidney Graft Survival After Simultaneous Pancreas and Kidney Transplantation (SPK).
A. Gruessner, M. Laftavi, V. Whittaker, Z. Acun, O. Pankowycz, R. Gruessner.
SUNY Upstate Medical University, Syracuse, NY
Introduction: In SPK transplants, the major risk factors for poor patient survival are early pancreas and/or kidney graft loss. In this study, we specifically examined…
2017 American Transplant Congress
Cell-Subset Diversity in Adipose Derived Regenerative Cells Used in Renal Ischemic Reperfusion Injury Treatment.
R. Lathan,¹ R. Ghita,^1,2 D. Hillyard,¹ P. Mark,^1,2 M. Clancy.^1,2
¹Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; ²School of Medicine, Dentistry and Nursing, Queen Elizabeth University Hospital, Glasgow, United Kingdom
Studies in our novel hybrid model of transplantion/ischemic reperfusion injury (IRI) in rat has demonstrated significant improvement in kidney function post injection of adipose-derived regenerative…