Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Avoidance or Reduction of Rituximab Might Improve Clinical Outcomes in ABO-Incompatible Renal Transplantation: Advantages and Disadvantages of Rituximab.
M. Okada,¹ Y. Watarai,¹ K. Iwasaki,² K. Murotani,³ T. Hiramitsu,¹ M. Tsujita,¹ N. Goto,¹ S. Narumi,¹ T. Kobayashi.²
¹Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ²Renal Transplant Surgery, Aichi Medical University, Nagakute, Japan; ³Clinical Research Center, Aichi Medical University, Nagakute, Japan
BACKGROUNDPretransplant desensitization with rituximab has contributed to drastic improvements in ABO-incompatible renal transplantation (ABO-I). However, ABO-I outcomes are still worse than those of ABO-identical or…
2017 American Transplant Congress
KDPI Usefulness in Spain: A Comparison with Classical ECD/SCD.
C. Arias-Cabrales,¹ M. Pérez-Sáez,¹ D. Redondo,¹ A. Buxeda,¹ C. Burballa,¹ S. Bermejo,¹ A. Sierra,¹ M. Mir,¹ A. Burón,² A. Zapatero,³ M. Crespo,¹ J. Pascual.¹
¹Nephrology, Hospital del Mar, Barcelona, Spain; ²Epidemiology and Evaluation, Hospital del Mar, Barcelona, Spain; ³Intensive Care Medicine, Hospital del Mar, Barcelona, Spain
Kidney donor shortage requires an expansion in selection criteria and objective tools to minimize discarded organs. Easy donor pretx variables such as age, standard/expanded criteria…
2017 American Transplant Congress
Post-Transplant Urinary Transglutaminase 2 Is a Potent Biomarker to Predict Kidney Allograft Inflammation or Fibrosis.
S. Shin,¹ Y.-M. Wee,¹ M. Choi,¹ Y. Cho,² H. Go,² Y. Kim,¹ D. Han.¹
¹Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ²Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested the hypothesis that quantification of urinary…
2017 American Transplant Congress
Course and Outcome of Renal Transplant Recipients Admitted to the Intensive Care Unit (ICU): Long Term Follow-Up.
A. El-Agroudy,¹ A. Alqahtani,¹ B. Dandi,² E. Farid,² A. Alaradhi.²
¹Medicine, Arabian Gulf University, Manama, Bahrain; ²Nephrology, Salmaniya Medical Complex, Manama, Bahrain
Background. The goal of this study was to evaluate the course and outcome of renal transplant recipients admitted to ICU and to analyze factors determining…
2017 American Transplant Congress
Poor Predictability of Quantiferon-TB Assay in Recipients and Donors for Tuberculosis Development After Kidney Transplantation in an Intermediate-TB-Burden Country.
J. Yang,¹ J. Ryu,¹ J. Jang,² J.-G. Lee,² C. Ahn.¹
¹Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; ²Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
Background. Tuberculosis (TB) is a common opportunistic infection after kidney transplantation (KT). Quantiferon-TB Gold In-Tube test (QFT) is widely used for assessing latent TB; however,…
2017 American Transplant Congress
Predictive Value of Pre-Transplant Cross-Match Techniques on Living Donor Kidney Transplant Outcomes.
M. Meneghini,¹ E. Melilli,¹ I. Revuelta,³ R. Rajalingam,² E. Rigol,⁴ S. Chandran,² F. Diekmann,³ F. Vincenti,² J. Cruzado,¹ J. Martorell,⁴ O. Bestard.¹
¹Kidney Transplant Unit, Bellvitge University Hospital; IDIBELL, Barcelona, Spain; ²Kidney Transplant Unit, UCSF Medical Centre, SanFrancisco; ³Kidney Transplant Unit, Clinic University Hospital, Barcelona, Spain; ⁴Immunology Department, Clinic University Hospital, Barcelona, Spain
Study aim: To investigate the impact of different cross-match techniques and their combination before living-donor kidney transplantation(LDKT) on main clinical outcomes.Methods: Retrospective study including 394…
2017 American Transplant Congress
Impact of Timeliness of Assessment of Positive Cytomegalovirus Polymerase Chain Reaction Results in Abdominal Organ Transplant Recipients.
K. Roach, H. Triemer, M. Hurtik, A. Mehta.
Emory University Hospital, Atlanta, GA
Purpose: The purpose of this study was to evaluate the timeliness of assessment of positive cytomegalovirus (CMV) polymerase chain reaction (PCR) results. This study served…
2017 American Transplant Congress
CMV-Specific CD4⁺ T Cells in CMV-IgG-Seronegative Individuals Protect from CMV Viremia Following Transplantation with a CMV-Seropositive Donor Kidney.
N. Litjens, L. Huang, B. Dedeoglu, R. Meijers, M. Betjes.
Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands
A primary infection with cytomegalovirus (CMV) is one of the major threats following transplantation of a CMV-IgG-seropositive donor organ into a CMV-IgG-seronegative individual. Therefore, prophylactic…
2017 American Transplant Congress
Second-Line Therapy After Standard of Care in Antibody-Mediated Rejection: A Prospective Study.
D. Viglietti, A. Loupy, O. Aubert, E. Pillebout, C. Legendre, D. Glotz, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France
There is a marked heterogeneity in AMR patients' prognosis after SOC treatment including plasma exchange (PE) and intravenous immunoglobulins (IVIG). We investigated whether a composite…
2017 American Transplant Congress
DNA Hypermethylation Caused by Ischemia in Kidney Transplants Predicts Future Chronic Injury to the Allograft.
L. Heylen,^1,2,3,4 B. Thienpont,^3,4 M. Naesens,^1,2 J. Depreeuw,^3,4 P. Busschaert,^3,4 D. Kuypers,^1,2 I. Jochmans,^2,5 D. Monbaliu,^2,5 J. Pirenne,^2,5 D. Lambrechts,^3,4 B. Sprangers.^1,2
¹Nephrology, University Hospitals Leuven, Leuven, Belgium; ²Microbiology and Immunology, KU Leuven, Leuven, Belgium; ³Oncology, KU Leuven, Leuven, Belgium; ⁴VIB, Leuven, Belgium; ⁵Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Study Purpose: DNA demethylation results from hydroxymethylation and is inhibited by hypoxia. We investigated whether ischemia during kidney transplantation induces DNA methylation changes of the…