Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Activated Th1 and Th17 cT_FH Phenotype Correlates with DSA Production in Kidney Transplant Recipients.
C. Macedo, P. Fadakar, K. Hadi, B. Ellinof, A. Zeevi, S. Hariharan, D. Metes.
University of Pittsburgh, Starzl Transplantation Institute, Pittsburgh
Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx). The…
2017 American Transplant Congress
Update of a Placebo-Controlled Trial of C1 Esterase Inhibitor for Prevention of Antibody Mediated Rejection (ABMR) in Highly-HLA Sensitized Patients.
A. Vo, J. Choi, A. Peng, K. Lim, L. Varanasi, R. Najjar, E. Huang, D. Puliyanda, S. Jordan.
Kidney Transplant, Cedars-Sinai Medical Center, LA, CA
INTRODUCTION: Desensitization (DES) strategies focus primarily on antibody reduction using IVIG, rituximab ± PLEX to prevent DSA-induced ABMR and rebound B-cell activity. Pathologic features of…
2017 American Transplant Congress
Donor/Recipient Matching Using the Creatinine Clearance Match Ratio (CCMR) Is Superior to the Kidney Donor Profile Index (KDPI) Predicting Early but Not Late Outcomes for Deceased Donor Kidney Transplantation.
J. Halldorson, N. Karimi.
Transplant Surgery, University of California, San Diego, CA; Surgery, Royal College of Surgeons, Dublin, Ireland
A Creatinine Clearance based Donor/Recipient matching strategy (CCMR) was developed to better optimize metabolic demand of the recipient with donor kidney function. Prior work in…
2017 American Transplant Congress
mRNA Biomarkers in Renal Allograft Protocol Biopsies Detected by the Nanostring Platform Predict Tolerance in Non-Human Primates.
M. Matsunami,¹ T. Oura,¹ I. Rosales,² R.-N. Smith,² B. Adam,³ M. Mengel,³ A. Cosimi,¹ R. Colvin,² T. Kawai.¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
Background. Renal allograft tolerance has been achieved in some but not all MHC mismatched kidneys in non-human primates (NHPs) and humans after induction of transient…
2017 American Transplant Congress
On the Pathogenesis of Post-Transplant Diarrhea in Kidney Transplant Recipients.
J. Lee,¹ M. Mcgruder,¹ L. Zhang,¹ M. Thangamani,¹ D. Dadhania,¹ L. Westblade,¹ M. Satlin,¹ A. Robertson,² L. Ling,² Y. Taur,² E. Pamer,² M. Suthanthiran.¹
¹Medicine, Weill Cornell, NY, NY; ²Medicine, Memorial Sloan Kettering Cancer Center, NY, NY
Introduction. Post-transplant diarrhea is a frequent complication after kidney transplantation but its etiology is unknown in the majority of cases; herein, we investigated whether post-transplant…
2017 American Transplant Congress
Highly Sensitized Patients and the Association of Early Cardiovascular Disease: Analysis of Korean Organ Transplantation Registry(KOTRY) Data.
J. Jeong,¹ J. Yang,² M. Kim,³ S. Shin,⁴ B. Chung,⁵ S. Han,⁶ C. Ahn.⁷
¹Department of Nephrology, Ajou University School of Medicine, Suwon, Korea; ²Transplantation Center, Department of Surgery, Seoul National University Hospital, Seoul, Korea; ³Department of Transplant Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; ⁴Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ⁵Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea; ⁶Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea; ⁷Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Introduction : In recent studies, immune sensitization was associated with increased mortality in wait-listed kidney transplant candidates. We investigated whether the risk of immune sensitization…
2017 American Transplant Congress
Poor Outcome of Polyomavirus -Associated Nephropathy with Glomerular Parietal Epithelial Cells Infected by Polyomavirus.
G. Huang,¹ W. Chen,² J. Qiu,¹ X. Chen,¹ L. Chen,¹ C. Wang.¹
¹Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Background: Bowman's capsular epithelium infected by polyomavirus(Py) in polyomavirus -associated nephropathy (PyVAN) is infrequent and considered as the advanced stage of the disease. The aim…
2017 American Transplant Congress
Longer Pre-Transplant Dialysis Exposure Is More Frequent in Living Donor Kidney Transplantation (LDTX) Involving Lower Income Donor and Recipients and Is Associated with an Increased Risk of LDTX Failure.
J. Gill, C. Rose, J. Lesage, Y. Joffres, J. Gill.
UBC, Vancouver, Canada
Background: Pre-emptive transplantation is known to be associated with superior LDTX outcomes, but the impact of pre-transplant (pre-TX) dialysis exposure on LDTX outcomes are less…
2017 American Transplant Congress
Donor Genetic Background Determines the Severity of Delayed Graft Function Following Kidney Transplantation in Mice.
L. Qiu, J.-J. Wang, X. Yeap, Z. Zheng, M. He, M. Abecassis, Z. Zhang.
Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
Background: Delayed graft function (DGF) has been associated with poor clinical transplant outcomes. Current mouse models of kidney transplant or acute kidney injury induced by…
2017 American Transplant Congress
Development of Transplant Glomerulopathy in Recipients with Antibody Mediated Rejection: Activation of Inflammatory Pathway Through Renal Poly (ADP-Ribose) Polymerase (PARP).
B. Ozdemir,¹ F. Ozdemir,² E. Baskin,² M. Haberal.³
¹Pathology, Baskent University, Ankara, Turkey; ²Pediatric Nephrology, Baskent University, Ankara, Turkey; ³Transplant Surgery, Baskent University, Ankara, Turkey
Activation of PARP is a critical factor in the pathogenesis of various inflammatory and fibrotic process. Thus we aimed to show the integral of PARP…