2017 American Transplant Congress
The Use of Very High KDPI Kidneys in Elderly Kidney Transplant Recipients – Discarded in the U.S. but Successfully Transplanted in Europe.
Nephrology, Charité Berlin, Berlin, Germany
Background: Very limited data exist on long-term outcomes of very high KDPI kidneys in elderly (≥65 years) kidney transplant recipients (KTR). Discard rates of donor…2017 American Transplant Congress
Rapid Depletion of Circulating DSA and Treatment of Acute Antibody-Mediated Rejection with the Combination of CTLA-4Ig/Belatacept and Bortezomib in Mouse and Man.
1Sugery, University of Chicago, Chicago, IL; 2Surgery, The Ohio State University, Columbus, OH
Antibody mediated rejection (AMR) is a major cause of rejection, and there are limited therapeutic options for reversing alloantibody production when it is fully established.…2017 American Transplant Congress
Single Kidney Transplantation from DCD Maastricht Category 3 Donors ≥ 60 Years: Is It Safe?
Aim. Compared to DBD, DCD kidneys show higher rates of primary non function (PNF), DGF, rejection, and premature transplant (Tx) loss. Some authors have advised…2017 American Transplant Congress
Evolution of Lipid Profile and Major Adverse Cardiac Events in Kidney Transplant Recipients Converted from Calcineurin Inhibitor to Everolimus: 24-Month Subanalysis from Elevate Study.
1ELEVATE Study Group, Berlin, Germany; 2Novartis Pharma AG, Basel, Switzerland
PURPOSE: Posttransplant (post-Tx) lipid abnormalities may increase risk of cardiovascular (CV) events in kidney transplant recipients (KTxR). Previous analysis from ELEVATE (NCT01114529) study confirmed that…2017 American Transplant Congress
Pre-Transplant HLA-Specific B Cell Breadth of Reactivity in a Novel Multiplex Bead-Based Assay Predicts Rejection in Kidney Transplant Recipients.
1Northwestern University, Chicago; 2Icahn School of Medicine at Mount Sinai, New York
Introduction: Recipients with broad sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) are at higher immunologic risk for poor graft…2017 American Transplant Congress
Proteomic Profiles of Deceased Donor Kidney Biopsies Obtained Prior to Transplantation Correlate with Allograft Function at One Year.
Introduction:Cerebral injury during Donation after Brain Death (DBD) will induce a systemic inflammatory response affecting immediate kidney function and survival posttransplantation. Assessment of donor organ…2017 American Transplant Congress
Utility of Weighted Composite Endpoints in Kidney Transplantation.
Cleveland Clinic, Cleveland, OH
IntroductionAdvances in therapeutic development and innovation are stifled in transplantation based on difficulties demonstrating efficacy of novel interventions using standard endpoints. Current RCTs are constrained…2017 American Transplant Congress
Stability of Immune Phenotype, Alloreactive, and Antiviral Immunity After Switch to Belatacept-Based Regimen After Kidney Transplantation.
David Geffen School of Medicine at UCLA, Los Angeles, CA
Purpose: This investigator-initiated study examines the impact of belatacept on T cell immune phenotype and function.Methods: 14 patients who had completed the study protocol were…2017 American Transplant Congress
Urinary Proteomic Biomarkers Discovery for Prediction of Acute Rejection in Kidney Transplant Recipients.
Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea
Background: Early prediction and treatment of acute rejection are crucial in kidney transplant recipients (KTRs) to prevent allograft loss. Changes in the serum and urinary…2017 American Transplant Congress
Presence of Complement Activating Donor Specific Antibodies Is Associated with Poor Renal Allograft Survival: Two Centre Retrospective Study.
Introduction: Complement fixing donor specific antibodies (DSA) as detected by presence of C3d at the time of rejection is associated with poor graft outcome;no studies…
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