Articles tagged "Kidney transplantation"

2017 American Transplant Congress
APOL1 Genotype Does Not Affect Donor Renal Function Post Live Kidney Donation.
K. Koutroutsos,¹ R. Sergeant,² F. Powell,² C. Freeman,² R. Charif,¹ J. Galliford,¹ P. Brookes,² D. Taube,¹ M. Loucaidou.¹
¹Kidney and Transplant Center, Imperial College Healthcare NHS Trust, London, United Kingdom; ²Histocompatibility and Immunogenetics Laboratory, Imperial College Healthcare NHS Trust, London, United Kingdom
Background: Apolipoprotein-L1 (APOL1) risk variants have emerged as a predictor of renal disease in individuals of African Ancestry (AA). The effect of APOL1 risk variants…
2017 American Transplant Congress
Complement Activating Anti-HLA Antibodies: Identification of Specific Histo-Mmolecular Phenotype of Rejection for Complement-Targeting Therapy.
C. Lefaucheur,¹ B. Sis,² D. Viglietti,¹ L. Hidalgo,² O. Aubert,¹ D. Glotz,¹ C. Legendre,¹ A. Zeevi,³ P. Halloran,² A. Loupy.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²University of Alberta, Edmonton, Canada; ³University of Pittsburgh Medical Center, Pittsburgh
Addressing the heterogeneity of antibody-mediated allograft rejection by identifying phenotypes based on pathophysiology is critical for improving outcomes in transplantation. We investigated whether complement-binding anti-HLA…
2017 American Transplant Congress
CD47 Blockade Reduces Ischemia/Reperfusion Injury in Donation After Cardiac Death Rat Kidney Transplantation.
X. Wang,¹ M. Xu,¹ J. Jia,¹ Z. Zhang,¹ J. Gaut,² G. Upadhya,¹ P. Manning,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Washington University School of Medicine, Saint Louis; ²Pathology and Immunology, Washington University School of Medicine, Saint Louis; ³Tioma Therapeutics, Saint Louis
Purpose: We evaluated the potential effects of antibody-mediated CD47 blockade to modulate vascular endothelial nitric oxide activity and reduce ischemia reperfusion injury in a rat…
2017 American Transplant Congress
DNA Methylation Dynamics from Ischemia/Reperfusion Injury to Long-Term Allograft Function.
V. Bontha,¹ D. Maluf,¹ M. Dozmorov,² D. Bagchi,¹ K. Archer,³ V. Mas.¹
¹Surgery, UVA, Charlottesville; ²VCU, Richmond; ³OSU, Columbus
Background: We hypothesize that following early graft damage (e.g., ischemia reperfusion injury) post-kidney transplantation (KT), the graft response to injury and repair involve changes in…
2017 American Transplant Congress
Anti-CD40 mAb Promotes Kidney Immunoregulatory Capacity in NHP Transplants by Altering Kidney Tubular Cell (TEC) Expression of CD40 and IL-6.
J. Arp,¹ Y. Ma,¹ H. Yang,² A. El Warrak,¹ A. Haig,¹ W. Liu,¹ K. Reimann,³ P. Luke,¹ Z. Zhang,¹ D. Rothstein,⁴ A. Jevnikar.¹
¹Medicine, Pathology & Microbiology & Immunology, Western University, London, ON, Canada; ²Sichuan Provincial Hospital, Chengdu, Sichuan, China; ³University of Massachusetts, Boston, MA; ⁴University of Pittsburgh, Pittsburgh, PA
Treatment of cynolmolgus monkey (NHP) renal transplant recipients with a combination of 2 rhesus-mouse chimeric α-CD45RB (r6G3R1; 6G3) and α-CD40 (r2C10R4; 2C10) mAbs increased circulating…
2017 American Transplant Congress
A Mutation of the Erythropoietin Receptor Correlates with Improved Function of Deceased-Donor Renal Transplants.
M. Fischereder,¹ S. Friedrich,¹ U. Klingmüller,² T. Kauke,³ T. Breidenbach,⁴ D. Boesebeck,⁵ E. Angelika,⁵ C. Cohen,¹ B. Banas,⁶ M. Guba,⁷ M. Stangl,⁸ B. Krämer,⁹ C. Hugo,¹⁰ K. Lopau,¹¹ M. Stadtler,¹² T. Mone.¹²
¹Medizinische Klinik IV, Klinikum der LMU, Munich, Germany; ²DKFZ, Heidelberg, Germany; ³Klinikum der LMU, Munich, Germany; ⁴Chirurgische Klinik, Klinikum Augsburg, Augsburg, Germany; ⁵DSO Bayern, Munich, Germany; ⁶Nephrologie, Universitätsklinikum, Regensburg, Germany; ⁷Surgery, Klinikum der LMU, Munich, Germany; ⁸Surgery, Klinikum der TU, Munich, Germany; ⁹Innere Medizin IV, Universitätsklinikum, Mannheim, Germany; ¹⁰Innere Medizin, Universität Erlangen, Erlangen, Germany; ¹¹Innere Medizin 2, Universitätsklinikum, Würzburg, Germany; ¹²OneLegacy, Los Angeles
Erythropoietin (Epo) protects renal tubular cells from ischemia/reperfusion injury in experimental transplantation, suggesting a relevant effect of erythropoietin receptor (EPOR) mediated signalling. Previously 6 mutations…
2017 American Transplant Congress
Use of Hepatitis C Infected Organs for Kidney Transplantation: A Medical Decision Analysis.
B. Kiberd,¹ K. Doucette,² K. Tennankore.¹
¹Dalhousie University, Halifax, NS, Canada; ²University of Alberta, Edmonton, AB, Canada
Given that Hepatitis C (HCV) can be cured, organs from HCV+ deceased donors might be used in HCV- recipients if treatment at the time of…
2017 American Transplant Congress
Experience with Belatacept (CTLA4-Ig) Conversion in Highly HLA Sensitized (HS) and ABO-Incompatible (ABOi) Patients Who Received Incompatible Kidney Transplants Post Desensitization (DES).
J. Choi,¹ A. Peng,¹ A. Vo,¹ E. Huang,¹ R. Najjar,¹ S. Louie,¹ A. Kang,¹ S. Ge,¹ M. Toyoda,¹ X. Zhang,² S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
Introduction: Recent experience with belatacept (bela) in nonsensitized kidney tx recipients suggest that costimulatory blockade in a CNI-free environment results in superior graft survival &…
2017 American Transplant Congress
Steroid Withdrawal and De Novo Donor-Specific HLA Antibodies in Renal Transplant Patients: A Prospective, Randomized, Controlled Study in Parallel Groups. Preliminary Results.
J. Alonso-Titos,¹ P. Ruiz-Esteban,¹ E. Palma,¹ V. Lopez,¹ A. Caballero,² M. Leon,³ M. Cobos,⁴ J. Cruzado,⁵ J. Sellares,⁶ A. Torres,⁴ D. Hernandez.¹
¹Nephrology, Regional University Hospital and Malaga University, IBIMA, RD16/0009/0006, Malaga, Spain; ²Immunology, Regional University Hospital, Malaga, Spain; ³Pathology, Regional University Hospital, Malaga, Spain; ⁴Nephrology, Hospital Universitario de Canarias, CIBICAN, University of La Laguna, RD16/0009/0031, Tenerife, Spain; ⁵Nephrology, IDIBELL, Hospital de Bellvitge, RD16/0009/0003, Barcelona, Spain; ⁶Nephrology, Hospital Universitari Vall d'Hebron, RD 16/0009/0030, Barcelona, Spain
Introduction: Steroids represent a mainstay of immunosuppression after kidney transplant (KT). Steroid withdrawal reduces metabolic and cardiovascular complications, but whether it increases the risk of…
2017 American Transplant Congress
The Impact of Belatacept on Anti-HLA Antibodies of Highly Sensitized Kidney Transplant Recipients.
R. Parsons, H. Decker, T. Pearson, C. Larsen, R. Bray, H. Gebel.
Emory Transplant Center, Atlanta, GA
Background: Anti-HLA antibodies often prevent successful organ transplantation. Interestingly, belatacept limits de novo antibody production within the germinal center, but its impact on long-lived plasma…