Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Glucose Tolerance After Kideney Transplant Is Affected by Systemic Insulin Sensitivity Rather Than Usage of Tacrolimus.
D. Iwami,¹ A. Nakamura,² K. Hotta,¹ H. Sasaki,¹ T. Hirose,¹ H. Higuchi,¹ Y. Takada,¹ H. Miyoshi,² N. Shinohara.¹
¹Urology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan; ²Internal Medicine II, Hokkaido University Hospital, Sapporo, Hokkaido, Japan
Introduction and Objective: Tacrolimus and steroid can affect insulin secretion and insulin sensitivity, resulting in worsened glucose tolerance after kidney transplant (KTx). However, the effect…
2017 American Transplant Congress
Age-Related Differences in Gene Expression Among Kidney Allografts with Normal Histology and Calcineurin Inhibitor Nephrotoxicity.
E. Rhone,¹ S. Bontha,¹ P. Walker,² C. Dumur,³ D. Maluf,¹ J. Almenara,³ V. Mas.¹
¹University of Virginia, Charlottesville; ²Arkana Laboratories, Little Rock; ³Virginia Commonwealth University, Richmond
Background Most biomarker research first occurs in adult populations, with consequent extrapolation to children. However, age-related differences may impact gene expression, such as variations in…
2017 American Transplant Congress
Timing of HLA Testing as a Means of Reducing Cost and Increasing Efficiency of Living Kidney Donation.
E. Venniro, J. Taylor.
Medicine, University of Rochester Medical Center, Rochester, NY
Purpose: Creating an effective living kidney donor process can be a challenge for transplant centers. There needs to be a balance between efficiency, resources, patient…
2017 American Transplant Congress
Changes in Urinary Neutrophil Gelatinase Associated Lipocalin Combined with Urine Cytokines and Microalbuminuria as Predictors for Interstitial Fibrosis and Tubular Atrophy in Kidney Transplantation: A Matched-Pair Tissue Cohort Study.
W. Chancharoenthana,¹ A. Leelahavanichkul,¹ S. Wattanatorn,¹ J. Issara-Amphorn,² Y. Avihingsanon,¹ K. Praditpornsilpa,¹ N. Townamchai.¹
¹Division of Nephrology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; ²Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Background: Late graft loss from interstitial fibrosis - tubular atrophy (IF/TA) continues to be the “Achilles' heel” of kidney transplantation (KT). Long-term calcineurin inhibitors (CNIs)…
2017 American Transplant Congress
Hurdles to Broader Implementation of the A₂/A₂BàB Deceased Donor Kidney Allocation Provision.
I. Kim,¹ A. Wilk,² A. Robinson,² P. Martins,³ V. Whitaker,⁴ E. Ward,² C. Miles.⁵
¹Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ²United Network for Organ Sharing, Richmond, VA; ³Department of Surgery, University of Massachusetts, Worcester, MA; ⁴Department of Surgery, State University of New York, Syracuse, NY; ⁵Department of Medicine, University of Nebraska Medical Center, Omaha, NE
Background: A2/A2B to blood group B kidney transplantation has improved transplant rates among disadvantaged blood group B patients with equivalent long-term graft outcomes. 18 months…
2017 American Transplant Congress
Lower Mean Tacrolimus Troughs Increase Risk of De Novo Donor-Specific Antibodies in the First Year of Kidney Transplant.
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO
Development of de novo donor-specific antibodies (dnDSA) is the first step in the evolution of antibody-mediated rejection, which constitutes the leading cause of death-censored graft…
2017 American Transplant Congress
Significant Allosensitisation Despite Early, within 24 Hour, Graft Nephrectomy.
G. Lucisano,¹ P. Brookes,² E. Santos-Nunez,² N. Firmin,² N. Gunby,² S. Hassan,¹ A. Gueret-Wardle,¹ M. Willicombe,¹ D. Taube.¹
¹Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; ²Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom
Introduction: Although it is well known that allograft nephrectomy (Nx) is followed by the development of donor-specific antibodies (DSAs) even after a short transplant period,…
2017 American Transplant Congress
Tacrolimus Time in Therapeutic Range Predicts Adverse Clinical Outcomes in the First Year of Kidney Transplant.
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO
Tacrolimus (TAC) has a narrow therapeutic range, with its upper bounds limited by serious toxicities while TAC minimization strategies have demonstrated immunologic risk. Monitoring the…
2017 American Transplant Congress
Effect of Everolimus-Based Immunosuppressive Regimen on New Onset of Diabetes After Kidney Transplantation – A 24 Month Subanalysis from the ELEVATE Study.
H. Holdaas,¹ S. Chadban,¹ J. de Fijter,¹ L. Rostaing,¹ U. Mancilla,¹ P. Lopez,² G. Bader,² J. Cruzado,¹ M. van der Giet.¹
¹ELEVATE Study Group, Oslo, Norway; ²Novartis Pharma AG, Basel, Switzerland
Purpose: New onset diabetes after transplantation (NODAT) is a common metabolic complication which affects long-term patient survival and graft outcomes. Most of the immunosuppressive drugs…
2017 American Transplant Congress
Relationship Between Mixed Chimerism and Tolerance in HLA-Matched and -Mismatched Recipients of Kidney and Hematopoietic Cell Transplants.
S. Busque, J. Scandling, J. Shizuru, R. Lowsky, A. Shori, J. Kent, E. Engleman, S. Strober.
Stanford University, Stanford
Twenty-eight fully HLA-matched and 18 HLA haplotype- matched recipients were given combined kidney and hematopoietic cell transplants using a completely post-transplant conditioning regimen consisting of…