Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Course and Outcome of Renal Transplant Recipients Admitted to the Intensive Care Unit (ICU): Long Term Follow-Up.
A. El-Agroudy,¹ A. Alqahtani,¹ B. Dandi,² E. Farid,² A. Alaradhi.²
¹Medicine, Arabian Gulf University, Manama, Bahrain; ²Nephrology, Salmaniya Medical Complex, Manama, Bahrain
Background. The goal of this study was to evaluate the course and outcome of renal transplant recipients admitted to ICU and to analyze factors determining…
2017 American Transplant Congress
Poor Predictability of Quantiferon-TB Assay in Recipients and Donors for Tuberculosis Development After Kidney Transplantation in an Intermediate-TB-Burden Country.
J. Yang,¹ J. Ryu,¹ J. Jang,² J.-G. Lee,² C. Ahn.¹
¹Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; ²Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
Background. Tuberculosis (TB) is a common opportunistic infection after kidney transplantation (KT). Quantiferon-TB Gold In-Tube test (QFT) is widely used for assessing latent TB; however,…
2017 American Transplant Congress
Predictive Value of Pre-Transplant Cross-Match Techniques on Living Donor Kidney Transplant Outcomes.
M. Meneghini,¹ E. Melilli,¹ I. Revuelta,³ R. Rajalingam,² E. Rigol,⁴ S. Chandran,² F. Diekmann,³ F. Vincenti,² J. Cruzado,¹ J. Martorell,⁴ O. Bestard.¹
¹Kidney Transplant Unit, Bellvitge University Hospital; IDIBELL, Barcelona, Spain; ²Kidney Transplant Unit, UCSF Medical Centre, SanFrancisco; ³Kidney Transplant Unit, Clinic University Hospital, Barcelona, Spain; ⁴Immunology Department, Clinic University Hospital, Barcelona, Spain
Study aim: To investigate the impact of different cross-match techniques and their combination before living-donor kidney transplantation(LDKT) on main clinical outcomes.Methods: Retrospective study including 394…
2017 American Transplant Congress
Impact of Timeliness of Assessment of Positive Cytomegalovirus Polymerase Chain Reaction Results in Abdominal Organ Transplant Recipients.
K. Roach, H. Triemer, M. Hurtik, A. Mehta.
Emory University Hospital, Atlanta, GA
Purpose: The purpose of this study was to evaluate the timeliness of assessment of positive cytomegalovirus (CMV) polymerase chain reaction (PCR) results. This study served…
2017 American Transplant Congress
CMV-Specific CD4⁺ T Cells in CMV-IgG-Seronegative Individuals Protect from CMV Viremia Following Transplantation with a CMV-Seropositive Donor Kidney.
N. Litjens, L. Huang, B. Dedeoglu, R. Meijers, M. Betjes.
Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands
A primary infection with cytomegalovirus (CMV) is one of the major threats following transplantation of a CMV-IgG-seropositive donor organ into a CMV-IgG-seronegative individual. Therefore, prophylactic…
2017 American Transplant Congress
Second-Line Therapy After Standard of Care in Antibody-Mediated Rejection: A Prospective Study.
D. Viglietti, A. Loupy, O. Aubert, E. Pillebout, C. Legendre, D. Glotz, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France
There is a marked heterogeneity in AMR patients' prognosis after SOC treatment including plasma exchange (PE) and intravenous immunoglobulins (IVIG). We investigated whether a composite…
2017 American Transplant Congress
DNA Hypermethylation Caused by Ischemia in Kidney Transplants Predicts Future Chronic Injury to the Allograft.
L. Heylen,^1,2,3,4 B. Thienpont,^3,4 M. Naesens,^1,2 J. Depreeuw,^3,4 P. Busschaert,^3,4 D. Kuypers,^1,2 I. Jochmans,^2,5 D. Monbaliu,^2,5 J. Pirenne,^2,5 D. Lambrechts,^3,4 B. Sprangers.^1,2
¹Nephrology, University Hospitals Leuven, Leuven, Belgium; ²Microbiology and Immunology, KU Leuven, Leuven, Belgium; ³Oncology, KU Leuven, Leuven, Belgium; ⁴VIB, Leuven, Belgium; ⁵Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Study Purpose: DNA demethylation results from hydroxymethylation and is inhibited by hypoxia. We investigated whether ischemia during kidney transplantation induces DNA methylation changes of the…
2017 American Transplant Congress
De Novo Donor-Specific Antibody Formation After Kidney Retransplant Is Associated with Specificity Against Class I.
K. Atiemo,¹ B. Ho,¹ H. Bhagat,² E. Lee,^2,3 A. Daud,¹ R. Kang,¹ S. Montag,^1,4 L. Zhao,^1,4 J. Schwartz,² D. Ladner.¹
¹Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; ²Astellas Pharma Global Development, Northbrook; ³Now with UCB, Atlanta; ⁴Dept of Preventive Medicine, Northwestern University, Chicago
Retransplant (RTx) patients are often sensitized due to donor-specific antibody (DSA) formation, with higher acute rejection rates during subsequent transplants vs patients without DSA. However,…
2017 American Transplant Congress
Renal Transplant Patient Outcomes Following Plasmapheresis, Thymoglobulin, and Rituximab Induction for High Risk DSA Positive Recipients.
E. Lessmann,¹ M. Moaddab,¹ M. Manson,¹ A. Ram,² R. Kerman,² P. Jindra.²
¹Pharmacy, CHI St. Luke's Health Baylor St. Luke's Medical Center, Houston, TX; ²Immune Evaluation Laboratory, Baylor College of Medicine, Houston, TX
Background: Kidney transplantation is associated with improved survival and quality of life relative to dialysis for patients with end-stage renal disease (ESRD). Patients who are…
2017 American Transplant Congress
Prevention of Donor Specific Antibody Production After Skin Allografting by Mobilization of Endogenous Stem Cells Using a Combination of AMD3100 and Low-Dose FK506 in Rats.
A. Ahmadi,¹ L. Qi,¹ R. Wesson,¹ F. Dor,² J. Burdik,¹ B. Philosophe,¹ G. Williams,¹ A. Cameron,¹ Z. Sun.¹
¹Dept. of Surgery, Johns Hopkins University, Baltimore, MD; ²Dept. of Surgery, Imperial College Healthcare, London, United Kingdom
Background: We have developed a stem cell mobilizing strategy that enables long-term liver and kidney allograft survival without sustained immunosuppression in small and large animals…