Articles tagged "Kidney transplantation"

2017 American Transplant Congress
BKV Clearance Time Correlates with T-Cell Receptor Repertoire Shape and Exhaustion State of BKV-Specific T-Cells in Renal Transplant Patients with Severe BKV Infection.
U. Stervbo,^1,2 M. Nienen,¹ B. Weist,² P. Wehler,² T. Westhoff,¹ H.-D. Volk,² P. Reinke,² N. Babel.^1,2
¹Center for Translational Medicine, Medical Clinic I, Marienhospital Herne, University Hospital of the Ruhr-University Bochum, Bochum, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charité – University Medicine, Berlin, Germany
Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression…
2017 American Transplant Congress
Molecular Significance of Peritubular Capillaritis in Early Transplant Kidney Biopsies of Donor-Specific Antibody Negative Patients.
M. Ajaimy, P. O Broin, Y. Bao, E. Akalin.
Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx
Background: Peritubular capillaritis (PTC) is a part of microvascular inflammation seen in antibody-mediated rejection. However, it can be observed as an isolated lesion in early…
2017 American Transplant Congress
Increased Pro-Inflammatory and Decreased Interferon-Related Gene Expression in Older as Compared with Younger Kidney Transplant Recipients.
J. Schaenman, O. Beiard, E. Liang, T. Sidwell, V. Groysberg, M. Rosetti, B. Abdalla, E. Lum, S. Bunnapradist, T. Pham, G. Dannovitch, J. Veale, H. Gritsch, A. Karlamangla, S. Cole, E. Reed.
David Geffen School of Medicine at UCLA, Los Angeles, CA
Older transplant recipients experience increased rates of death and infection as compared with younger patients. Our previous studies demonstrated increased frequency of terminally differentiated and…
2017 American Transplant Congress
Predictive Value of Renal Transplant Scintigraphy for the Duration of Delayed Graft Function.
S. Benjamens,^1,2 R. Pol,¹ A. Glaudemans,² S. Berger,³ R. Slart.²
¹Surgery - Transplantation, University Medical Center Groningen, Groningen, Netherlands; ²Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, Netherlands; ³Internal Medicine - Division of Nephrology, University Medical Center Groningen, Groningen, Netherlands
Background: Renal scintigraphy (RS) is a widely used test for the assessment of the transplanted kidney (KTX). As RS cannot reliably distinguish between rejection and…
2017 American Transplant Congress
Does Choice of Induction Agent Affect Outcomes in Kidney Transplants from Deceased Donors with Acute Kidney Injury and Prolonged Cold Ischemia Time?
G. Dube, S. Mohan, M. Chiles.
Nephrology, Columbia University Medical Center, New York, NY
Kidneys with acute kidney injury (AKI) have a higher rate of DGF but similar outcomes to kidneys without AKI, although most data are with kidneys…
2017 American Transplant Congress
Differential Effect of Antibody Removal on ABO Blood Group Type Chain Specific Antibodies Over Time.
A. Bentall,¹ M. Jeyakanthan,² J. Pearcey,² B. Motyka,² C. Cairo,³ T. Lowary,³ J. Buriak,⁴ L. West,² S. Ball.¹
¹Department of Nephrology, University Hospital Birmingham, Birmingham, United Kingdom; ²Departs of Pediatrics, Surgery and Immunology, University of Alberta, Alberta Transplant Institute, Edmonton, Canada; ³Alberta Glycomics Centre, Univ of Alberta, Dept of Chemistry, Edmonton, Canada; ⁴Dept of Chemistry, National Institute of Nanotechnology, Edmonton, Canada
Introduction: The trisaccharide epitope defines A&B blood group antigens where antibody binds to subtype chains (I-VI), but only subtype II is expressed on cardiac vascular…
2017 American Transplant Congress
Worsening Rather Than Severe Acute Kidney Injury Affects Kidney Transplantation Outcomes.
M.-Y. Yu,¹ B. Yu,² Y. Kim,¹ S. Mi,³ J. Ha,³ J. Yang,³ Y. Kim,¹ H. Lee.¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; ²Internal Medicine, Soon Chun Hyang University Bucheon Hospital, Bucheon, Republic of Korea; ³Surgery, Seoul National University Hospital, Seoul, Republic of Korea
BackgroundThe growing evidence has suggested that deceased donor kidneys with acute kidney injury (AKI) may be a good solution to overcome organ shortage. Although previous…
2017 American Transplant Congress
Non-Directed Kidney Donor Candidate Referral, Care, and Attrition in an Online Portal.
R. Hays,¹ K. Schappe,¹ D. Kaufman,¹ D. Mandelbrot.²
¹Division of Transplant Surgery, University of Wisconsin Hospital and Clinics, Madison, WI; ²Division of Nephrology, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI
When non-directed live kidney donation (NDD) was first described in the early 2000s, a high rate of inquiry per actual donor was noted. Since then,…
2017 American Transplant Congress
M1 Macrophage-Induced Loss of KLF15 Promotes Chronic Podocyte Injury.
S. Han,^1,2 Y. Kim,¹ S. Lee,¹ H. Lee,^1,2 R.-H. Cha,² J. Lee,^1,2 J. Lee,² D. Kim,^1,2 Y. Kim,^1,2 S. Yang.^1,2
¹Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ²Kidney Research Institute, Seoul National University, Seoul, Korea
Background: Krüppel-like factor 15 (KLF15), kidney-enriched transcription factor, is known to participate in the differentiation of podocyte. However, the implication of KLF15 in chronic podocyte…
2017 American Transplant Congress
Do Perioperative Blood Transfusions Influence Kidney Transplant Outcomes in the Modern Era?
J. Lineen, J. Trac, Y. Li, O. Famure, J. Kim.
Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada
Background: Blood transfusions are a well-established risk factor for human leukocyte antigen sensitization in kidney transplant candidates. To date, relatively few studies have explored the…