Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Performance Comparison of Barcoded Oligos and Standard qPCR on Matched FFPE and RNAlater-Submerged Human Kidney Allograft Samples.
T. Sigdel, M. Nguyen, D. Dobi, J. Liberto, S.-C. Hsieh, F. Vincenti, M. Sarwal, Z. Laszik.
University of California, San Francisco, San Francisco
Background: Gene expression profiling can improve the diagnostic ability of kidney allograft injury. Fresh tissue is the favored study material for transcriptomic analysis due to…
2017 American Transplant Congress
Impact of Immunosuppression Adherence on De Novo Donor-Specific Antibody Formation in Renal Transplant Recipients in Canada: A Modeling Analysis.
J. Howell,¹ R. Pollock,² J. Schwartz.³
¹Astellas Pharma Global Development, Inc., Markham, ON, Canada; ²Ossian Health Economics and Communications GmbH, Basel, Switzerland; ³Astellas Pharma Global Development, Inc., Northbrook, IL
Acute rejection rates and short-term graft survival have improved substantially as a result of advances in immunosuppression (IS), though longer-term graft survival rates have improved…
2017 American Transplant Congress
Single-Center, Prospective, Open Label Pilot Study to Investigate the Effectiveness of Everolimus Associated with Mycophenolic Acid and Prednisone in Adult Patients Submitted to an Allograft Renal Transplant with Calcineurin Inhibitor Withdrawl on Week 16th.
L. Giordano,^1,2 M. Lasmar,^1,2 H. Vianna,^1,2 E. Lasmar.^1,2
¹Renal Transplant Unit, Hospital Universitário Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; ²Nephrology Department, Rede Mater Dei de Saúde, Belo Horizonte, Minas Gerais, Brazil
Although CI have proven efficacy in kidney transplantation worldwide, they are drugs with nephrotoxic potential and may contribute to chronic renal allograft nephropathy. As a…
2017 American Transplant Congress
Prediction of Renal Allograft Acute Rejection Using a Novel Non-Invasive Model Based on Acoustic Radiation Force Impulse.
C. Yang,¹ Y. Jin,² S. Wu,³ T. Zhu,¹ W. He.²
¹Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ²Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China; ³Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China
Point shear wave elastography (p-SWE) based on acoustic radiation force impulse (ARFI) is a novel technology to quantify tissue stiffness by measuring shear wave speed…
2017 American Transplant Congress
Glucose Tolerance After Kideney Transplant Is Affected by Systemic Insulin Sensitivity Rather Than Usage of Tacrolimus.
D. Iwami,¹ A. Nakamura,² K. Hotta,¹ H. Sasaki,¹ T. Hirose,¹ H. Higuchi,¹ Y. Takada,¹ H. Miyoshi,² N. Shinohara.¹
¹Urology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan; ²Internal Medicine II, Hokkaido University Hospital, Sapporo, Hokkaido, Japan
Introduction and Objective: Tacrolimus and steroid can affect insulin secretion and insulin sensitivity, resulting in worsened glucose tolerance after kidney transplant (KTx). However, the effect…
2017 American Transplant Congress
Age-Related Differences in Gene Expression Among Kidney Allografts with Normal Histology and Calcineurin Inhibitor Nephrotoxicity.
E. Rhone,¹ S. Bontha,¹ P. Walker,² C. Dumur,³ D. Maluf,¹ J. Almenara,³ V. Mas.¹
¹University of Virginia, Charlottesville; ²Arkana Laboratories, Little Rock; ³Virginia Commonwealth University, Richmond
Background Most biomarker research first occurs in adult populations, with consequent extrapolation to children. However, age-related differences may impact gene expression, such as variations in…
2017 American Transplant Congress
Timing of HLA Testing as a Means of Reducing Cost and Increasing Efficiency of Living Kidney Donation.
E. Venniro, J. Taylor.
Medicine, University of Rochester Medical Center, Rochester, NY
Purpose: Creating an effective living kidney donor process can be a challenge for transplant centers. There needs to be a balance between efficiency, resources, patient…
2017 American Transplant Congress
Changes in Urinary Neutrophil Gelatinase Associated Lipocalin Combined with Urine Cytokines and Microalbuminuria as Predictors for Interstitial Fibrosis and Tubular Atrophy in Kidney Transplantation: A Matched-Pair Tissue Cohort Study.
W. Chancharoenthana,¹ A. Leelahavanichkul,¹ S. Wattanatorn,¹ J. Issara-Amphorn,² Y. Avihingsanon,¹ K. Praditpornsilpa,¹ N. Townamchai.¹
¹Division of Nephrology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; ²Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Background: Late graft loss from interstitial fibrosis - tubular atrophy (IF/TA) continues to be the “Achilles' heel” of kidney transplantation (KT). Long-term calcineurin inhibitors (CNIs)…
2017 American Transplant Congress
Hurdles to Broader Implementation of the A₂/A₂BàB Deceased Donor Kidney Allocation Provision.
I. Kim,¹ A. Wilk,² A. Robinson,² P. Martins,³ V. Whitaker,⁴ E. Ward,² C. Miles.⁵
¹Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ²United Network for Organ Sharing, Richmond, VA; ³Department of Surgery, University of Massachusetts, Worcester, MA; ⁴Department of Surgery, State University of New York, Syracuse, NY; ⁵Department of Medicine, University of Nebraska Medical Center, Omaha, NE
Background: A2/A2B to blood group B kidney transplantation has improved transplant rates among disadvantaged blood group B patients with equivalent long-term graft outcomes. 18 months…
2017 American Transplant Congress
Lower Mean Tacrolimus Troughs Increase Risk of De Novo Donor-Specific Antibodies in the First Year of Kidney Transplant.
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO
Development of de novo donor-specific antibodies (dnDSA) is the first step in the evolution of antibody-mediated rejection, which constitutes the leading cause of death-censored graft…