Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Pre-Transplant Evaluation of KSORT^SM to Assess Risk for Rejection in Highly Sensitized Patients.
S. Nandoe,¹ S. Roedder,³ S. Hsieh,¹ T. Sigdel,¹ P. Lindner,⁴ J. Ekberg,⁴ J. Alberu,⁵ F. Vincenti,¹ M. Sarwal.¹
¹UCSF, San Francisco, CA; ²Immucor, Norcross, GA; ³Gothenburg University, Gothenburg, Sweden; ⁴Salvador Zubiran, Mexico City, Mexico
Study purpose: To investigate the kSORTSM molecular expression assay for immune risk assessment in renal transplant (tx) recipients prior to tx for correlation of pre-tx…
2017 American Transplant Congress
A Search for a Biomarker Which Predicts Belatacept-Resistant Rejection.
G. de Graav,¹ C. Baan,¹ M. Clahsen-van Groningen,² R. Kraaijeveld,¹ M. Dieterich,¹ W. Verschoor,¹ D. Roelen,³ M. Cadogan,¹ J. van de Wetering,¹ J. van Rosmalen,⁴ W. Weimar,¹ D. Hesselink.¹
¹Internal Medicine, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands; ²Pathology, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands; ³Immunohematology and Blood Transfusion, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands; ⁴Biostatistics, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands
Belatacept, an inhibitor of the CD28-CD80/86 costimulatory pathway, has been associated with a higher acute rejection risk than ciclosporin. We sought to identify a biomarker…
2017 American Transplant Congress
Kidney Injury Molecule-1 Mitigates Tissue Damage from Transplant Renal Ischemia Reperfusion Injury.
J. Lee,^1,2 X. Zhang,² A. Haig,³ D. Lian,² P. Anderson,² R. Navaratnam,² L. Gunaratnam.^1,2
¹Department of Microbiology and Immunology, Western University, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Department of Pathology, Western University, London, ON, Canada
Ischemia reperfusion injury (IRI) at the time of organ harvesting is unavoidable, may cause delayed renal graft function, and is associated with premature graft loss.…
2017 American Transplant Congress
Circulating Donor-Specific Anti-HLA Antibodies Accelerate the Progression of Interstitial Fibrosis in Kidney Allografts.
C. Gosset, D. Viglietti, M. Rabant, E. Pillebout, A. Bouquegneau, J. Taupin, D. Glotz, C. Legendre, J. Duong Van-Huyen, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France
Interstitial fibrosis represents a major cause of kidney allograft failure. Addressing the causes of accelerated ageing of kidney allografts represents an important challenge to improve…
2017 American Transplant Congress
Belatacept for Chronic Antibody-Mediated Rejection in Kidney Transplantation.
D. Kumar,¹ G. Gupta,¹ J. Reeve,² P. Sanghi,¹ S. Bobba,¹ M. Levy,¹ C. Bhati,¹ P. Kimball,¹ H. Fattah,¹ A. King,¹ H. Massey,¹ P. Halloran.²
¹Virginia Commonwealth University, Richmond; ²Alberta Transplant Applied Genomics Center, Edmonton, Canada
Background: Chronic antibody mediated rejection (cAMR) is a major cause of long-term kidney transplant (KT) loss. Antibody or immune cell depletional therapies have unclear efficacy…
2017 American Transplant Congress
Outcomes with Kidney Transplant from Deceased Donors with Acute Kidney Injury and Prolonged Cold Ischemia Time: UNOS Analysis.
G. Dube, S. Mohan, M. Chiles.
Nephrology, Columbia University Medical Center, New York, NY
Longer cold ischemia time (CIT) is associated with an increased risk of delayed graft function and may increase the risk of graft failure. Kidneys with…
2017 American Transplant Congress
Kidney Transplant Recipient Intermediate and Long Term Outcomes for Living Donor Gifted Lithiasis.
S. Doshi, M. Yaqub, T. Taber, M. Mujtaba, D. Mishler, O. Adebiyi, C. Sundaram, J. Powelson, A. Sharfuddin.
Indiana University Health, Indianapolis
BACKGROUND: Nephrolithiasis is considered at least a relative contraindication to living donor nephrectomy due to the potential for adverse outcomes of recurrence, obstruction and infection.…
2017 American Transplant Congress
C5b-9 Deposition in Glomerular Capillaries Is Responsible for Poor Allograft Survival in Antibody-Mediated Rejection.
V. Goutaudier,¹ H. Perrochia,¹ M. Marron-Wojewodzki,¹ F. Garo,¹ C. René,¹ N. Pirot,² G. Mourad,¹ M. Le Quintrec.¹
¹University Hospital, Montpellier, France; ²Cancer Research Institute, Montpellier, France
Introduction: C4d (scare of C4 cleavage) deposition in peritubular capillaries (PTC), a marker of complement activation, is associated with antibody-mediated rejection (AMR) in kidney transplantation.…
2017 American Transplant Congress
Current Status of HIV-to-HIV Transplants in the United States.
C. Durand,¹ A. Tobian,^1,3 N. Desai,¹ A. Cameron,¹ N. Dagher,⁴ D. Brown,¹ S. Halpern,¹ S. Bagnasco,¹ D. Ostrander,¹ A. Redd,¹ S. Huprikar,² B. Haydel,² S. Lerner,² S. Florman,² D. Segev.¹
¹JHU, Baltimore, MD; ²Mount Sinai, New York, NY; ³NIH, Bethesda, MD; ⁴NYU, New York, NY
The HIV Organ Policy Equity (HOPE) Act allows transplantation using organs from HIV-infected (HIV+) donors for HIV+ individuals in the United States under research protocols.…
2017 American Transplant Congress
Dialysis Facility Providers' Awareness of Racial Disparities in Kidney Transplantation.
J. Kim, M. Basu, L. Plantinga, C. Escoffery, S. Pastan, R. Patzer.
Emory University, Atlanta
Background Racial disparities persist in access to kidney transplant (KTx) in the US, where African Americans (AAs) have lower rates of waitlisting than whites. Despite…