Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Changes in Peripheral Blood Gene Expression Profile After Calcineurin Inhibitor (CNI) Withdrawal in Kidney Transplant Recipients.
P. Cravedi,¹ W. Zhang,¹ D. Salomon,² M. Fribourg,¹ G. Remuzzi,³ E. Gotti,³ F. Casiraghi,³ Z. Yi,¹ P. Heeger,¹ CTOT09, ATHENA Consortia.
¹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York; ²Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla; ³Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy
CNI are effective in kidney transplantation but their off-target effects make CNI withdrawal (w/d) desirable. Published studies showed that clinical parameters cannot differentiate the ~50%…
2017 American Transplant Congress
Employment Patterns After Kidney Transplantation: Rates, Contributing Factors, and Outcomes.
J. Kim, J. Rana, M. Ashwin, Y. Li, O. Famure.
Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada
Background: The costs of productivity lost in transplant patients poses a concern, as a significant number of patients are of working age. Furthermore, healthcare and…
2017 American Transplant Congress
A New Methodology for Measuring and Monitoring Equity in Access to Deceased Donor Kidney Transplants.
D. Stewart, A. Wilk, W. Cherikh, A. Harper, R. Urban, D. Klassen, E. Edwards.
United Network for Organ Sharing, Richmond, VA
Background: The OPTN monitors progress on increasing the number of transplants, improving patient outcomes, and other goals. However, a well-established methodology for assessing system performance…
2017 American Transplant Congress
The Degree of NK Cell Activation Determines the Ability of Donor-Specific Antibodies to Mediate Acute vs. Chronic Rejection of Kidney Allografts.
T. Yagisawa,^1,2 T. Tanaka,¹ N. Dvorina,¹ A. Valujskikh,¹ W. Baldwin 3rd,¹ R. Fairchild.¹
¹Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH; ²Urology, Tokyo Women's Medical University, Tokyo, Japan
While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…
2017 American Transplant Congress
Fosfomycin Tromeltamol (FOS) Is an Effective Alternative in Post Renal Transplant Urinary Tract Infection Prophylaxis Caused by Escherichia coli and Enterococcus faecalis without Increasing Resistance Rate.
J. Arreola-Guerra,¹ J. Alberu,² L. Morales-Buenrostro,² E. Maravilla,³ R. Rosado,³ J. Sifuentes.³
¹Nephrology and Transplantation, Centenario Hospital Miguel Hidalgo, Aguascalientes, Mexico; ²Transplantation, Instituto Nacional de Nutrición Salvador Zubirán, Mexico, Mexico; ³Medicine, Instituto Nacional de Nutrición Salvador Zubirán, Mexico, Mexico
Urinary tract infection (UTI) is one of the most important complications in renal transplant recipients (rTR) during the first year after renal transplantation (RT). Antimicrobial…
2017 American Transplant Congress
KDPI and Small (<20 kg) Pediatric Kidney Donors.
J. Smith,^1,2 S. Gustafson,² A. Wey,² J. Snyder,² A. Israni.²
¹Seattle Children's Hospital, Seattle; ²Scientific Registry of Transplant Recipients, Minneapolis
Use of small (≤20 kg) donor kidneys in pediatric candidates has declined under the new kidney allocation system (KAS), from 5.0% of pediatric kidney-alone transplants…
2017 American Transplant Congress
Benefits of Induction in Recipients of Acute Renal Failure Donor Kidneys.
M. Barrett, A. Smith, K. Woodside, R. Sung.
University of Michigan, Ann Arbor
Kidneys from donors with acute renal failure (ARF) are often discarded due to concerns for DGF and graft failure. Induction immunosuppression can be used to…
2017 American Transplant Congress
When Does the Learning Curve End? A High-Volume Single Center Experience with Laparoscopic Donor Nephrectomy Over 16 Years.
S. Yamanaga,^1,2,3 A. Posselt,¹ C. Freise,¹ C. Niemann,¹ A. Rosario,¹ D. Fernandez,¹ T. Kobayashi,³ A. Ahearn,⁴ M. Tavakol,¹ S.-M. Kang.¹
¹Division of Transplant Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA; ²Department of General Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan; ³Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; ⁴Department of Transplant Surgery, UMass Memorial Medical Center, Worcester, MA
Purpose: No studies for any type of surgery have examined learning curves beyond a decade or 100 cases because surgeon turnover and lack of complete…
2017 American Transplant Congress
Immune Sensitization During Pregnancy Reduces Long-Term Benefit for Kidney Recipients of Offspring Living Donors.
J. Cohen,¹ L. Owei,² D. Sawinski,¹ P. Porrett.²
¹Medicine, University of Pennyslvania, Philadelphia, PA; ²Surgery, University of Pennsylvania, Philadelphia, PA
Background Offspring-to-mother kidney transplantations are associated with excellent short-term outcomes given the accuracy of histocompatibility testing and potency of immunosuppression. However, immunologic memory responses in…
2017 American Transplant Congress
Risk Factors and Consequences of De Novo Anti-HLA Donor Specific Antibodies in Kidney Transplant Recipients: The Force Awakens.
B. Javaid, S. Rosen-Bronson, D. Li, M. Awwad, A. Gilbert, S. Ghasemian, J. Verbesey, P. Abrams, M. Grafals, J. Fenton, C. Cannon, J. Rapisura, J. Moore, M. Cooper.
Kidney and Pancreas Transplant Program, MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Georgetown University School of Medicine, Washington, DC
Background: Presence of anti-HLA donor specific antibodies (DSAs) has been associated with inferior kidney transplant outcomes. Identification of risk factors for de novo DSAs could…