Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Survival in Deceased Donor Kidney Transplant by Kidney Donor Profile Index versus Intensive Home Hemodialysis
A. Nishio-Lucar,¹ G. Lyons,² S. Bose,³ J. Ma,² K. Awuah,³ R. Lockridge.³
¹Internal Medicine, University of Virginia, Charlottesville, VA; ²Public Health Science, University of Virginia, Charlottesville, VA; ³Lynchburg Nephrology Physicians, Lynchburg, VA.
In an era of donor scarcity, high Kidney Donor Profile Index (KDPI) >85% organs can serve as a pathway to timely transplant. We previously reported…
2018 American Transplant Congress
Metabolic Acidosis after Kidney Transplantation: Prevalence, Risk Factors and Graft Outcome in a French Cohort
F. Garo, I. Szwarc, G. Mourad, M. Le Quintrec, J-.E. Serre.
Nephrology, University Hospital of Montpellier, Montpellier, France.
Background: Metabolic acidosis (MA) lead to several complications in more advanced stages of chronic kidney diseases (CKD) and promotes CKD progression. Acidosis is a common…
2018 American Transplant Congress
Treatment Outcomes of FSGS Recurrence
J. Mansur,¹ D. Chang,² G. Medeiros,¹ M. Cristelli,¹ L. Viana,¹ S. Stopa,¹ C. Felipe,¹ G. Kirsztajn,¹ H. Tedesco-Silva.¹
¹Hospital do Rim, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; ²Hospital Nacional Cayetano Heredia, Universidad Peruana Cayetano Heredia, Lima, Peru.
Background: Recurrence of FSGS (focal segmental glomerulosclerosis) after kidney transplant occurs in 30% of adults and up to 80% of children and has impact on…
2018 American Transplant Congress
Predictors of Kidney Transplant Recipient Readmissions
A. Crane, M. Eltemamy, D. Jacobsen, T. Coy, A. Sun, P. Babbar, M. Ponziano, E. Poggio, A. Wee, R. Fatica, V. Krishnamurthi.
Glickman Urology and Nephrology, Cleveland Clinic, Cleveland.
Introduction: Readmission rates for kidney transplant recipients is high and widely variable with a range of 18-47% nationwide. We aimed to characterize kidney transplant patients…
2018 American Transplant Congress
Association of Immunosuppressive Therapy Regimen with Sepsis Outcomes among Kidney Transplant Recipients
J. Donnelly,¹ P. MacLennan,¹ R. Mannon,¹ R. Saran,² J. Baddley,¹ H. Wang,³ G. McGwin, Jr.,¹ P. Muntner.¹
¹University of Alabama at Birmingham, Birmingham, AL; ²University of Michigan, Ann Arbor, MI; ³University of Texas Health Science Center, Houston, TX.
OBJECTIVE: Immunosuppressive therapy (IST) could impact sepsis outcomes by altering the host immune response. We examined the associations of IST regimens with sepsis outcomes among…
2018 American Transplant Congress
Performance of Molecular Diagnostic Algorithms of T-Cell Mediated Kidney Rejection (TCMR) in Non-Transplant Biopsies with Interstitial Nephritis
Z. Wang,¹ P. Liu,² G. Tseng,² G. Zeng,¹ P. Randhawa.¹
¹Transplant Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA; ²Epidemiology, Graduate School of Public Health, and University of Pittsburgh, Pittsburgh, PA.
DNA microarray based tools for the diagnosis of TCMR have been developed and are now being offered commercially. There is need to further evaluate the…
2018 American Transplant Congress
A Single Center Outcomes Analysis of UNOS Defined "Hard to Place Kidneys"
Y. Qazi, K. Lee, A. Jones, L. Aguirre, M. Parma, M. Smogorzewski, T. T. Maw, L. Sher.
Keck Medical Center at USC, Los Angeles, CA.
The discard rate of potentially usable kidneys remains dismal despite a critical shortage of organs. The Scientific Registry of Transplant Recipients (SRTR) now provides a…
2017 American Transplant Congress
CD16a-Activated NK Cells in ABMR Are Highly Similar to CD3-Activated Effector T Cells in TCMR.
M. Parkes, P. Halloran, L. Hidalgo.
University of Alberta, Edmonton, Canada
BACKGROUND: NK cell CD16a and T cell CD3 activate shared pathways. Since NK cell CD16a activation occurs in antibody-mediated rejection (ABMR) and T cell CD3…
2017 American Transplant Congress
Infusion of Polyclonal Tregs Modulates Subclinical Kidney Transplant Inflammation: Final Report of TASK Pilot Trial.
S. Chandran, Q. Tang, M. Sarwal, Z. Laszik, A. Putnam, T. Sigdel, E. Tavares, J. Bluestone, F. Vincenti.
UCSF, San Francisco
Purpose:Treg therapy can reverse established inflammation in animal models. We conducted a pilot safety & feasibility trial of Treg therapy for subclinical kidney transplant inflammation.Methods:Peripheral…
2017 American Transplant Congress
Characterization of Human Plasma Cell Proteasome Adaptations to Proteasome Inhibitor Therapy: A Precision Medicine Approach to Overcome Drug Resistance in Desensitization.
J. Driscoll,¹ S. Tremblay,¹ P. Brailey,¹ A. Girnita,¹ R. Alloway,¹ B. Aronow,² H. Singh,² E. Woodle.²
¹U of Cincinnati, Cincinnati, OH; ²Cincinnati Children's, Cincinnati, OH
Purpose: Bone marrow niche-resident plasma cells (BMNRPCs) exhibit variable sensitivity to proteasome inhibitor (PI) therapy. Here, we characterized alterations in the gene and protein expression…