Articles tagged "Kidney transplantation"

2018 American Transplant Congress
How Safe is Immunosuppression Maintenance 1 Year after Renal Allograft Failure?
A. Mena-Gutierrez, K. Alquadan, A. Santos, K. Womer, M. Casey.
University of Florida, Gainesville.
In 2013, our center opened a specialty clinic to maintain immunosuppression (IS) after renal graft failure in an attempt to minimize further sensitization in retransplant…
2018 American Transplant Congress
A Novel, Dose-Adjusted Tacrolimus Intrapatient Variability Model Identifies High-Risk Kidney Transplant Recipients Better Than Existing Methodologies
J. Kim, S. Wilson, Y. Song, J. Schwartz.
Astellas Pharma Global Development, Inc., Northbrook.
Intrapatient variability (IPV) of tacrolimus trough concentration (TTC) is a risk factor for inferior transplant outcomes. However, assessing IPV is problematic, relying on fixed dose…
2018 American Transplant Congress
Outcomes of Donor and Recipient Obesity in Kidney Transplantation
J. Buggs,¹ R. Mehta,² M. Adesunkanmi,² J. Boone,² E. Rogers,³ A. Kumar,⁴ V. Bowers.¹
¹Transplant Surgery, Tampa General Medical Group, Tampa General Hospital, Tampa, FL; ²Pre-Med Undergraduate, University of South Florida, Tampa, FL; ³Transplant Research, Tampa General Hospital, Tampa, FL; ⁴Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL.
Introduction: Obesity (BMI >30) is a world health epidemic projected to increase the incidence of diabetes, the leading cause of kidney failure. The shortage of…
2018 American Transplant Congress
The Role of Pre-Emptive Antibiotic Therapy in Kidney Recipients of Donors with Urine-Only Positive Cultures
P. Cabrera,¹ A. Centeno,¹ J. Revollo,¹ J. Camargo.²
¹Department of Pharmacy, Jackson Memorial Hospital, Miami, FL; ²Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.
Background: Donor derived infections (DDIs) can lead to significant morbidity and mortality in solid organ transplant patients. In recent years, the disparity between the need…
2018 American Transplant Congress
End Stage Kidney Disease Risk Profile in Living Kidney Donors for Pediatric versus Adult Kidney Transplant Recipients in Australia and New Zealand
D. Lee,^1,2 J. Whitlam,² N. Cook,² A. Walker,³ F. Ierino,⁴ M. Roberts,¹ J. Kausman.³
¹Department of Renal Medicine, Eastern Health, Melbourne, VIC, Australia; ²Department of Nephrology, Austin Health, Melbourne, VIC, Australia; ³Department of Nephrology, Royal Children's Hospital, Melbourne, VIC, Australia; ⁴Department of Nephrology, St Vincent's Hospital, Melbourne, VIC, Australia.
Background: Living kidney donors (LKD) for pediatric kidney transplant recipients (KTR) have a high motivation to donate due to the clear benefits to the KTR…
2018 American Transplant Congress
New SLK Allocation Policy May Impact Transplant Outcomes in Women
G. Cullaro,¹ R. Hirose,² J. Lai.¹
¹Medicine, University of California, San Francisco, San Francisco, CA; ²Transplant Surgery, University of California, San Francisco, San Francisco, CA.
Background: Previous SLK allocation was based on serum creatinine(Cr), a metric that disadvantaged women(W) relative to men(M). A SLK policy change utilizes eGFR, which accounts…
2018 American Transplant Congress
Hypothermic Machine Perfusion Protects Rabbit Kidney Graft through Down Regulation SPP1-MMP7 Signaling Axis
Q. Hu,¹ Z. Zhong,¹ S. Xue,¹ W. Liang,¹ J. Lan,¹ J. Liang,¹ Y. Xiong,¹ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; ²The 3rd Xiangya Hospital of Central Sourth University, Changsha, China.
Background: Multicenter studies have indicated that hypothermic machine perfusion(HMP) can be used to prolong cold ischemia time with high-quality preservation and allow utilization of kidney…
2017 American Transplant Congress
Biological Interplay Between Circulating HLA-sp Alloreactive Memory B-Cells and Long-Lived Plasma Cells in Kidney Transplant Patients Undergoing Chronic ABMR.
S. Luque,² M. Lúcia,⁴ M. Jarque,² E. Crespo,² E. Melilli,¹ J. Martorell,³ J. Cruzado,^1,2 J. Torras,^1,2 J. Grinyó,^1,2 O. Bestard.^1,2
¹Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain; ²Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ³Immunogenetics Laboratory, Hospital Clínic, Barcelona, Spain; ⁴Transplant Immunology, School of Medicine, Stanford
Alloreactive humoral responses are one of the main causes of immune-mediated allograft injury in kidney transplantation. Different biological compartments are involved in the generation and…
2017 American Transplant Congress
Shared Epitopes Contribute to Accumulation of Highly Sensitized Patients in Kidney Paired Donation Program.
S. Stepkowski, B. Mierzejewska, C. Baum, D. Bekbolsynov, R. Brunner, J. Kopke, S. Rees, M. Rees.
University of Toledo, Toledo, OH
Introduction: Kidney Paired Donation (KPD) programs suffer from the accumulation of highly sensitized patients. We evaluated the sensitization patterns in our KPD program-by comparison of…
2017 American Transplant Congress
Pre-Transplant Evaluation of KSORT^SM to Assess Risk for Rejection in Highly Sensitized Patients.
S. Nandoe,¹ S. Roedder,³ S. Hsieh,¹ T. Sigdel,¹ P. Lindner,⁴ J. Ekberg,⁴ J. Alberu,⁵ F. Vincenti,¹ M. Sarwal.¹
¹UCSF, San Francisco, CA; ²Immucor, Norcross, GA; ³Gothenburg University, Gothenburg, Sweden; ⁴Salvador Zubiran, Mexico City, Mexico
Study purpose: To investigate the kSORTSM molecular expression assay for immune risk assessment in renal transplant (tx) recipients prior to tx for correlation of pre-tx…