Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Donor Specific Antibodies and Clinical Outcomes in Kidney Transplant Recipients
S. Wan,^1,2 S. Chadban,^1,2 K. Wyburn.^1,2
¹Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²Sydney Medical School, University of Sydney, Sydney, Australia.
BACKGROUND: Donor specific antibodies (DSA) have been implicated in the development of acute rejection (AR) and graft dysfunction in kidney transplant recipients (KTx). However, limited…
2018 American Transplant Congress
Successful Utilization of Deceased Donor Kidney Allografts with KDPI>85 in Older Recipients
A. Nickkholgh,¹ A. Agarwal,¹ A. Nishio Lucar,² K. Brayman,¹ A. Doyle,² J. Oberholzer.¹
¹Dept. of Surgery, University of Virginia Health System, Charlottesville, VA; ²Dept. of Internal Medicine, University of Virginia Health System, Charlottesville, VA.
Background: High kidney donor profile index (KDPI >85%) organs can grant earlier access to transplantation particularly for those who are frail, have limited waiting time…
2018 American Transplant Congress
Renal Allograft Transplantation among Middle Eastern Population with Alemtuzumab Induction
G. Mitro, O. Ekwenna, M. Rees, J. Ortiz.
University of Toledo College of Medicine, Toledo, OH.
Introduction: Renal allograft recipients of Middle Eastern (ME) heritage are often grouped together with Caucasians (CAU) for analysis. This abstract seeks to explore whether ME…
2018 American Transplant Congress
Use of Granulocyte Colony-Stimulating Factor for Leukopenia Post-Renal Transplant
S. Hamel,¹ V. Kuo,² D. Johnson,¹ R. Bloom,³ D. Sawinski,³ J. Trofe-Clark.^1,3
¹Pharmacy, Hosp of Univ. of Pennsylvania, Philadelphia; ²Pharmacy, Univ. of California San Francisco, San Francisco; ³Renal Division, Perelman School of Medicine, Univ. of Pennsylvania, Philadelphia.
Purpose: Leukopenia is a frequent complication in renal transplant recipients (RTRs). Granulocyte colony-stimulating factor (G-CSF) accelerates white blood cell (WBC) count recovery; but, published experience…
2018 American Transplant Congress
Results of UNOS Survey on Diagnosis, Treatment and Follow-Up Evaluation of Clinical and Sub-Clinical TCMR and ABMR in Kidney Transplant Recipients
P. Sood,¹ W. Cherikh,² A. Toll,² R. Mehta,¹ C. Puttarajappa,¹ S. Hariharan.¹
¹University of Pittsburgh Medical Center, Pittsburgh; ²UNOS, Richmond.
Management strategies for treatment of rejection post ktx vary among centers. Controlling minor degrees of inflammation can prevent chronic allograft scarring. To study the diverse…
2018 American Transplant Congress
Weight Changes before and after Kidney Donation
A. Bugeja,¹ S. Harris,² J. Ernst,¹ K. D. Burns,¹ G. Knoll,¹ E. G. Clark.¹
¹Medicine, The Ottawa Hospital, Ottawa, ON, Canada; ²Faculty of Science, University of Ottawa, Ottawa, ON, Canada.
IntroductionLiving kidney donors remain at low risk of end stage kidney disease but obese and overweight donors' risk is increased. We aimed to describe the…
2018 American Transplant Congress
Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation
B. Ezekian, J. Kwun, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Cochran, K. Kroning, J. Yi, S. Knechtle.
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:Sensitized kidney transplant (KT) recipients have poor access to transplantation and inferior outcomes when transplanted. Conventional methods of desensitization remove donor specific antibody (DSA) temporarily,…
2018 American Transplant Congress
The TRANSFORM Study: Infection Outcomes with Everolimus Plus Reduced Calcineurin Inhibitor and Mycophenolate Plus Standard Calcineurin Inhibitor Regimens in De Novo Kidney Transplant Recipients
F. Vincenti, J. Cruzado, S. Mulgaonkar, V. Garcia, D. Kuypers, M. Buchler, F. Citterio, U. Huynh-Do, W-.L. Luo, P. Bernhardt, C. Sommerer.
TRANSFORM Study Group, Novartis Pharma AG, Basel, Switzerland.
Purpose: Post-transplant (Tx) bacterial and viral infections are known to affect graft and patient survival. Accumulating evidence supports the protective effect of everolimus (EVR) against…
2018 American Transplant Congress
Endothelin-1 Type A Receptor Antibodies Are Associated with Elevated Il-8, Arteritis and Decline in Renal Function in Pediatric Renal Transplant Recipients
M. Pearl,¹ J. Grotts,¹ M. Rossetti,¹ Q. Zhang,¹ P. Weng,¹ E. Reed,¹ E. Tsai Chambers.²
¹University of California, Los Angeles, Los Angeles, CA; ²Duke University, Durham, NC.
Background: We have recently shown that the non-HLA antibody, AT1R-Ab, is prevalent and associated with poor outcomes in pediatric kidney transplant recipients (KTRs). The prevalence…
2018 American Transplant Congress
Immunophenotype of Cells Infiltrating the Graft Explains the Benefits of Belatacept
J. Furuzawa-Carballeda,¹ N. Uribe-Uribe,² G. Mondragon-Ramirez,⁴ J. Arreola-Guerra,⁵ R. Reyes-Acevedo,⁵ M. Vilatoba,³ R. Chavez-Fernandez,¹ F. Lopez-Verdugo,¹ A. Lopez-Toledo,⁴ G. Mondragon-Salgado,⁴ J. Alberu.³
¹Immunology, Inst. Nal. C. Medicas y Nutricion SZ, Mexico City, Mexico; ²Pathology, Inst. Nal. C. Medicas y Nutricion SZ, Mexico City, Mexico; ³Transplantation, Inst. Nal. C. Medicas y Nutricion SZ, Mexico City, Mexico; ⁴Inst Mex de Trasplantes, Cuernavaca, Mexico; ⁵Transplantation, C. Hospital Miguel Hidalgo, Aguascalientes, Mexico.
Previously, we found greater amounts of FoxP3 cells and lower amounts of CD4+/IL-17A+ and senescent cells in belatacept (Bela) patients compared to patients under cyclosporine…