Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Outcomes after HIV+ Kidney Transplant: A HOPE in Action Study
C. Durand,¹ M. Bowring,¹ A. Tobian,¹ D. Brown,¹ N. Desai,¹ S. Bagnasco,¹ D. Ostrander,¹ A. Redd,¹ S. Huprikar,² B. Haydel,² S. Lerner,² S. Florman,² S. Chandran,³ A. Chao,³ J. Locke,⁴ S. Mehta,⁴ R. Freidman,⁵ N. Turgeon,⁵ A. Massie,¹ D. Segev.¹
¹JHU, Baltimore, MD; ²Mount Sinai, New York, NY; ³UCSF, San Francisco, CA; ⁴UAB, Birmingham; ⁵Emory, Atlanta.
The HIV Organ Policy Equity (HOPE) Act allows HIV-infected donor (HIV D+) organs to be transplanted into HIV+ recipients (HIV R+) under research protocols. We…
2018 American Transplant Congress
Alemtuzumab is Associated with Higher Rates of De Novo Donor Specific Antibody (DSA) in Patients with No Pre-Transplant DSA
N. Bath, S. Parajuli, G. Leverson, M. Jorgenson, J. Fose, T. Ellis, D. Kaufman, A. Djamali, R. Redfield.
Surgery, University of Wisconsin, Madison, WI.
Introduction: Basiliximab, alemtuzumab, and thymoglobulin are the most commonly used induction agents in the US. While many centers use depleting antibody induction therapy in patients…
2018 American Transplant Congress
Efficacy of At-Home Transplant Education on Transplant Knowledge and Pursuit in Low-Income and Black Dialysis Patients with Varying Educational Characteristics
A. Waterman,^1,2 J. Peipert,^1,2 J. Beaumont.²
¹Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Terasaki Research Institute, Los Angeles, CA.
The Explore Transplant @ Home (ETH) randomized controlled trial assessed the efficacy of two supplementary education strategies for kidney transplant (KT) in dialysis centers: 1)…
2018 American Transplant Congress
Chronic Antibody Mediated Rejection in Renal Allografts Shows RNA Transcript Patterns That Evolve with Stage
A. Rosales,¹ B. Adam,² M. Mengel,² T. Oura,¹ M. Matsunami,¹ T. Kawai,¹ A. Cosimi,¹ R. Smith,¹ R. Colvin.¹
¹Massachusetts General Hospital, Boston, MA; ²University of Alberta, Edmonton, AB, Canada.
Purpose. Four stages of chronic antibody mediated rejection (CAMR) in renal allografts have been defined in humans and non-human primates (NHP), beginning with donor specific…
2018 American Transplant Congress
Identifying the Specific Causes of Kidney Allograft Loss: A Population Based Study
C. Loheac, O. Aubert, D. VIglietti, N. Kamar, M. Delahousse, C. Lefaucheur, A. Loupy.
Paris Translational Research Center for Organ Transplantation, Paris, France.
Understanding the specific causes of kidney allograft loss is mandatory to improve the longevity of kidney allografts. However, the current literature is limited by the…
2018 American Transplant Congress
Frailty Assessment Pilot Study in Older Kidney Transplant Recipients
B. Abdalla, B. Hale-Durbin, J. Schaenman, C. Lee, G. Danovitch.
UCLA, Los Angeles, CA.
Older patients are more often being considered for kidney transplantation, however many candidates are on the waitlist for several years. We sought to evaluate the…
2018 American Transplant Congress
Enhancement of Intrinsic Apoptosis via Bcl-2 Inhibition Promotes Induction of Robust Mixed Chimerism and Renal Allograft Tolerance without Myelosuppression in Nonhuman Primates
T. Oura,¹ A. Dehnadi,¹ I. Rosales,¹ H. Sasaki,¹ P. Cippa,² R. Fehr,² A. Cosimi,¹ T. Kawai.¹
¹Surgery, Center for Transplantation Science, Massachusetts General Hospital, Boston, MA; ²Medicine, University of Zurich, Zurich, Switzerland.
Background: Successful induction of mixed chimerism (MC) and renal allograft tolerance has been achieved in both nonhuman primate (NHP) and man following conditioning that included…
2018 American Transplant Congress
Tacrolimus Metabolism in Subjects with Potentially Absent CYP3A Activity
A. Scheibner,¹ R. Remmel,² D. Schladt,³ W. Oetting,¹ W. Guan,⁴ B. Wu,⁴ C. Door,⁵ A. Israni,⁵ P. Jacobson.¹
¹Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN; ²Medicinal Chemistry, University of Minnesota, Minneapolis, MN; ³Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Biostatistics, University of Minnesota, Minneapolis, MN; ⁵Department of Medicine, Hennepin County Medical Center, Minneapolis, MN.
Purpose: Tacrolimus (TAC) is a well-known cytochrome P450 (CYP) 3A4 and 3A5 substrate. Common single nucleotide polymorphisms (SNPs) in these genes are significantly related to…
2018 American Transplant Congress
Inflammation in Scarred Areas (i-IF/TA): Defining the Response to Standard Treatment of T Cell-Mediated Rejection in Kidney Recipients
D. Viglietti, O. Aubert, J-.P. Duong Van Huyen, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France.
The 2017 Banff meeting has focused on the importance of defining the potential role of i-IF/TA as a component of the T cell-mediated rejection (TCMR)…
2018 American Transplant Congress
HLA Eplet Mismatch and Donor Specific Antibodies in Kidney Transplantation
S. Wan,^1,2 S. Angel de Wilde,² B. Rosales,² S. Chadban,^1,2 K. Wyburn.^1,2
¹Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²Sydney Medical School, University of Sydney, Sydney, Australia.
BACKGROUND: Although HLA matching improves graft survival in kidney transplant recipients (KTx), eplet mismatches provide higher resolution information, and could better predict the development of…