Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Association of Leptin with Cystatin C in Kidney Allograft Dysfunction
A. Bera,¹ M. Watson,² N. Gana,¹ J. Karaian,¹ S. Radhakrishnan,¹ M. Subramanian,¹ D. Little,² R. Nee,² A. Chatterjee,¹ S. Rothwell,¹ H. Pollard,¹ R. Jindal,³ M. Srivastava.¹
¹Anatomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD; ²Nephrology, USU-Walter Reed, Bethesda, MD; ³Surgery, USU-Walter Reed, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring recipients of kidney allografts to predict acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft…
2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…
2018 American Transplant Congress
Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage
G. Irish,^1,2 M. Hockley,^1,2 S. Kireta,^1,2 J. Johnson,^1,2 R. Carroll.^1,2
¹Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²The Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…
2018 American Transplant Congress
The Clinical Significance of Pretransplant C1q Assay Status in Positive Crossmatch Kidney Transplantation
J. Lee,¹ D. Kim,¹ B. Park,² S. Song,³ J. Lee,⁴ Y. Jung,¹ J. Lee,¹ J. Lee,¹ B. Kim,⁵ M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Korea; ²Laboratory Medicine, Asan MEdical Center, Seoul, Korea; ³Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; ⁴Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; ⁵Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.
Background: Patients with a pretransplant donor-specific antibodies (DSA) are at higher risk for antibody-mediated rejection (AMR). However, not all DSA have the same pathogenetic potential.…
2018 American Transplant Congress
Desensitization to Facilitate Matching in a Large, National Kidney Paired Exchange Clearinghouse
C. Holscher,¹ A. Thomas,¹ K. Jackson,¹ C. Haugen,¹ M. Ronin,² A. Waterman,^3,4 A. Massie,^1,5 J. Garonzik Wang,¹ D. Segev.^1,5
¹Johns Hopkins School of Medicine, Baltimore; ²National Kidney Registry, New York; ³David Geffen School of Medicine at UCLA, Los Angeles; ⁴Terasaki Research Institute, Los Angeles; ⁵Johns Hopkins School of Public Health, Baltimore.
In kidney paired exchange (KPE) programs, the use of incompatible transplantation has been necessary to prevent long waiting times for sensitized candidates and to facilitate…
2018 American Transplant Congress
Retrospective Study of Cryptococcosis in Kidney Transplant Recipients from a Single Center
R. Wang, M. Cen, J. Lin, H. Huang, W. Peng, J. Wu.
Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Background: The mortality of Cryptococcosis remains unchanged among kidney transplant recipients(KTR) over the past two decades, and the prognosis of Cryptococcosis is yet unpredicted. Hence,…
2018 American Transplant Congress
Impact of Postoperative Serum Chloride Changes on Graft Function and Acute Rejection in Recipients of Living Kidney Transplants
V. Vakil, D. Keys, M. Junghare, S. Jackson, D. Berglund, A. Matas, S. Riad.
U of MN, Minneapolis.
Background: In the non-transplant setting, hyperchloremia has been associated with kidney injury. We sought to study the impact of serum chloride (SCl) on transplant outcomes.Methods:…
2018 American Transplant Congress
Progression of Vertebral Bone Disease among Kidney Allograft Recipients on Steroid Maintenance
E. Abuhelaiqa,¹ M. Alkadi,¹ M. Jarman,² J. Mahmoud,² A. Hamdi,¹ A. Ashor,¹ A. Nauman,¹ M. Asim,¹ O. Fituri,¹ H. Al-Malki.¹
¹Nephrology-Internal Medicine, Hamad Medical Coperation, Doha, Qatar; ²Transplantat Surgery, Hamad Medical Coperation, Doha, Qatar.
BackgroundOsteoporosis has been recognized as a significant cause of morbidity post kidney transplantation. We aimed to evaluate the prevalence of osteoporosis at one year post…
2018 American Transplant Congress
Effect of Ethnicity on Recipient Characteristics, Kidney Transplant Provision and Outcomes in a High-Volume National Health Service Hospital
E. Favi,¹ C. Puliatti,² M. Ferraresso,¹ R. Cacciola.²
¹Kidney Transplant, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; ²Kidney Transplant, Barts Health NHS Trust, The Royal London Hospital, London, United Kingdom.
Background. Several reports have demonstrated that outcomes of kidney transplantation (KTx) can be influenced by recipient's ethnicity and social status. However, available data mostly refer…
2018 American Transplant Congress
Intensified Immunosuppression Improves Early Renal Allograft Function after Transplantation in a Porcine Model with Extended Asystolic Warm Ischemic Time
M. Xu,¹ X. Wang,¹ S. Garcia-Aroz,¹ B. Banan,¹ B. Rabe,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ P. Manning,² J. Gaut,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; ²Arch Oncology, St. Louis, MO; ³Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
PURPOSE: Extensive ischemia-reperfusion injury significantly increases the immunogenicity of renal allograft which may be associated with increased risk of acute rejection (AR). This study investigated…