Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Validating Molecular Microscope Readings and Estimating Agreement with Histology
P. Halloran, J. Reeve, The INTERCOMEX Study Group.
ATAGC, Edmonton, Canada.
We previously described a microarray diagnostic system (MMDx) for rejection in 1208 kidney transplant biopsies (J. Reeve et al. JCI Insight 2 (12), 2017). The…
2018 American Transplant Congress
A Low Level of De Novo DSA Sialylation is Associated with a Decreased of Allograft Survival in Non-Sensitized Kidney Transplant Recipients
M. Bonnet,^1,2 V. Pernin,^1,3 J-.E. Serre,¹ V. Georgescu,⁴ M. Le Quintrec,^1,2,3 G. Mourad,^1,2 J-.F. Eliaou,^2,5 C. Rene.^2,5
¹Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, Montpellier University Hospital, Montpellier, France; ²University of Medicine, Montpellier University, Montpellier, France; ³Inserm U1183, IRMB, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France; ⁴Department of Medical Information, Montpellier University Hospital, Montpellier, France; ⁵Department of Immunology, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France.
Background. In kidney transplantation, de novo donor specific antibodies (dnDSA) are associated with antibody-mediated rejection (ABMR) and graft failure. While appearance of dnDSA, there is…
2018 American Transplant Congress
Cost Impacts of Alternative Kidney Transplant Immunosuppression: A National Cohort Study
K. Lentine,¹ D. Axelrod,² V. Dharnidharka,³ H. Xiao,¹ D. Brennan,⁴ D. Segev,⁴ H. Randall,¹ R. Ouseph,¹ A. Naik,⁵ N. Lam,⁶ T. Alhamad,³ B. Kasiske,⁷ G. Hess,⁸ M. Schnitzler.¹
¹Saint Louis Univ, St. Louis; ²Lahey Clinic, Burlington; ³Washington Univ, St. Louis; ⁴Johns Hopkins, Baltimore; ⁵Univ Michigan, Ann Arbor; ⁶Univ Alberta, Edmonton, Canada; ⁷Hennepin County, Minneapolis; ⁸Symphony Health, Conshohocken.
Economic outcomes are increasingly considered along with clinical efficacy to guide choice of alternative therapies. We examined the cost impact of kidney transplant (KTx) induction…
2018 American Transplant Congress
Longitudinal Molecular Assessment of Renal Allograft and Short-Term Outcome: Markers of Injury and Recovery
S. Bontha,¹ A. Fernandez,¹ E. Bardhi,¹ L. Gallon,² V. Mas,¹ D. Maluf.¹
¹Surgery, UVA, Charlottesville; ²NWU, Chicago.
Background: Ischemia reperfusion (I/R) is influenced by both donor and recipient characteristics and affects early graft function and the recovery process. To understand underlying mechanisms…
2018 American Transplant Congress
DNA Methylation Age and Differential Patterns of DNA Methylation in Older Compared with Younger Kidney Transplant Recipients
J. Schaenman, X. Zhou, R. Guo, M. Rossetti, E. Liang, B. Abdalla, E. Lum, S. Bunnapradist, G. Danovitch, E. Reed, D. Elashoff.
David Geffen School of Medicine at UCLA, Los Angeles, CA.
Introduction: Older transplant recipients experience increased rates of infection and death, but decreased rates of rejection, suggesting a role of immune dysfunction. Analysis of DNA…
2018 American Transplant Congress
Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant
A. Brubaker,¹ D. Stoltz,¹ M. Grskovic,² R. Woodward,² A. Gallo.¹
¹Department of Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; ²CareDx, Brisbane, CA.
Background: Recently, high immunologic risk patients comprise a significant percentage of the total adult renal transplants performed yearly. Surveillance management of these patients and interpretation…
2018 American Transplant Congress
Clinical Heterogeneity of Early Anamnestic Donor Specific Antibody Responses in Kidney Transplantation
A. Loethen,¹ A. Lichvar,¹ S. Tremblay,¹ A. Shields,^1,2 A. Dao,¹ M. Cardi,² P. Brailey,¹ A. Girnita,¹ B. Abu Jawdeh,¹ R. Alloway,¹ E. Woodle.¹
¹U of Cincinnati, Cincinnati, OH; ²Christ Hospital, Cincinnati, OH.
Anamnestic donor specific antibody(DSA) responses in the early post-transplant period may threaten the renal transplant(RTx). We hypothesize earlier DSA detection will allow minimization of RTx…
2018 American Transplant Congress
The Results of Plasmapheresis and Anti-CD20 Based Desensitization without Intravenous Immunoglobulin in Positive Crossmatch Kidney Transplants
H. Kwon, Y. KIm, J. Choi, S. Shin, J. Jung, M. Cho, J. Kim, D. Han.
Asan Medical Center, Seoul, Korea.
This study examined the mid-term clinical outcomes in positive crossmatch kidney transplants (XMKT) for patients who received desensitization with plasmapheresis (PP) and anti-CD20 based regimens…
2018 American Transplant Congress
Using Machine Learning and Simulation to Compare High Risk Kidney Transplant Survival to Waiting for a Non High Risk Organ
E. Mark, D. Goldsman, P. Keskinocak, B. Gurbaxani.
H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA.
The purpose of this study is to help patients decide whether to accept a kidney from a donor with a potential disease. We consider infectious…
2018 American Transplant Congress
Outcomes of Kidney Transplantation from HBsAg Positive Donors to HBsAb Positive Recipients
G. Chen, C. Wang, Z. Wu, X. Liu, C. Wang, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Objective To investigate the outcomes of transplanting kidneys from HBsAg positive donors to HBsAb positive recipients.Methods We retrospectively collected data of 57 kidney transplants from…