Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Association of Leptin with Cystatin C in Kidney Allograft Dysfunction
A. Bera,¹ M. Watson,² N. Gana,¹ J. Karaian,¹ S. Radhakrishnan,¹ M. Subramanian,¹ D. Little,² R. Nee,² A. Chatterjee,¹ S. Rothwell,¹ H. Pollard,¹ R. Jindal,³ M. Srivastava.¹
¹Anatomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD; ²Nephrology, USU-Walter Reed, Bethesda, MD; ³Surgery, USU-Walter Reed, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring recipients of kidney allografts to predict acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft…
2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…
2018 American Transplant Congress
Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage
G. Irish,^1,2 M. Hockley,^1,2 S. Kireta,^1,2 J. Johnson,^1,2 R. Carroll.^1,2
¹Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²The Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…
2018 American Transplant Congress
The Clinical Significance of Pretransplant C1q Assay Status in Positive Crossmatch Kidney Transplantation
J. Lee,¹ D. Kim,¹ B. Park,² S. Song,³ J. Lee,⁴ Y. Jung,¹ J. Lee,¹ J. Lee,¹ B. Kim,⁵ M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Korea; ²Laboratory Medicine, Asan MEdical Center, Seoul, Korea; ³Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; ⁴Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; ⁵Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.
Background: Patients with a pretransplant donor-specific antibodies (DSA) are at higher risk for antibody-mediated rejection (AMR). However, not all DSA have the same pathogenetic potential.…
2018 American Transplant Congress
Desensitization to Facilitate Matching in a Large, National Kidney Paired Exchange Clearinghouse
C. Holscher,¹ A. Thomas,¹ K. Jackson,¹ C. Haugen,¹ M. Ronin,² A. Waterman,^3,4 A. Massie,^1,5 J. Garonzik Wang,¹ D. Segev.^1,5
¹Johns Hopkins School of Medicine, Baltimore; ²National Kidney Registry, New York; ³David Geffen School of Medicine at UCLA, Los Angeles; ⁴Terasaki Research Institute, Los Angeles; ⁵Johns Hopkins School of Public Health, Baltimore.
In kidney paired exchange (KPE) programs, the use of incompatible transplantation has been necessary to prevent long waiting times for sensitized candidates and to facilitate…
2018 American Transplant Congress
Transplant Tourism and Invasive Fungal Infection
F. Al Ismaili,¹ A. Metry,³ M. Al Riyami,⁵ F. Khamis,⁶ F. Shaheen,⁷ A. Hola,⁴ I. Al Salmi.²
¹The Renal Medicine, The Royal Hospital, Muscat, Oman; ²The Renal Medicine, The Royal Hospital, Muscat, Oman; ³The Renal Medicine, The Royal Hospital, Muscat, Oman; ⁴Histopathology, SQUH, Muscat, Oman; ⁵Infectious Diseases, The Royal Hospital, Muscat, Oman; ⁶SCOT, SCOT, RIyadh, Saudi Arabia; ⁷The Renal Medicine, The Royal Hospital, Muscat, Oman; ⁸The Renal Medicine, The Royal Hospital, Muscat, Oman.
Deceased and live-related Renal transplant (RTX) are widespread approved methods throughout the world. In-addition, commercial-RTX has gained an access at certain places driven by financial…
2018 American Transplant Congress
The Implications of Impaired Glucose Tolerance after Kidney Transplantation
F. Tinney, Jr.,¹ S. Norman,² A. Naik,² D. Cibrik,² R. Sung,² D. Frietze,³ M. Stegall,⁴ M. Samaniego,² C. Jay.³
¹Henry Ford Hospital, Detroit, MI; ²University of Michigan, Ann Arbor, MI; ³UT Health San Antonio, San Antonio, TX; ⁴Mayo Clinic, Rochester, MN.
Background: Post-transplantation diabetes mellitus (PTDM) is highly prevalent after kidney transplantation and associated with significant morbidity. Routine utilization of screening oral glucose tolerance tests (OGTT)…
2018 American Transplant Congress
Impact of Vitamin D Status on Immune-Mediated Graft Function Following Kidney Transplantation
C. Pham,¹ B. Pierce,¹ S. Bapat,² S. Kuten,¹ L. Moore,³ A. Gaber.³
¹Department of Pharmacy, Houston Methodist Hospital, Houston; ²College of Pharmacy, University of Houston, Houston; ³Department of Surgery, Houston Methodist Hospital, Houston.
Ubiquitous expression of vitamin D receptors on antigen-presenting cells has sparked interest into its immunomodulatory effects. While previous literature has described the effect of vitamin…
2018 American Transplant Congress
Predictors of Immunosuppressive Medication Adherence in Chinese Renal Transplant Recipients: Marital Status and Immunosuppressive Medication Beliefs
J. Liu,¹ S. Liu,² J. Xie,¹ J. Yan.¹
¹The Third Affiliated Hospital, Central South University, Changsha, China; ²Adelphi University College of Nursing and Public Health, Garden City, NY.
Purpose: Our aim was to examine the beliefs on immunosuppressive medication (IM) and IM adherence in Chinese renal transplant recipients, and explore the predictors of…
2018 American Transplant Congress
Application of RNA-Seq Derived Diagnostic Algorithms of T-Cell Mediated Kidney Rejection (TCMR) to DNA Microarray-Based Gene Expression Datasets
Z. Wang,¹ L. Pan,² Z. Lyu,² P. Liu,³ G. Tseng,³ P. Randhawa.¹
¹Department of Pathology, The Thomas E Starzl Transplantation Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA; ²Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China; ³Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Recent years have seen the development of DNA microarray based tools for the diagnosis of TCMR using fresh frozen tissue. This study has accomplished the…