Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Effect of Conversion to CTLA4Ig Treatment on Tacrolimus-Induced Diabetic Rats
J. Il,¹ L. Jin,¹ K. Luo,¹ S. Lim,¹ Y. Shin,¹ E. Ko,^1,2 B. Chung,^1,2 C. Yang.^1,2
¹Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea.
Background: The effect of conversion to cytotoxic T-lymphocyte-associated protein 4 immunoglobulin (CTLA4Ig) treatment on tacrolimus (TAC)-induced renal dysfunction is well known, but its effect on…
2018 American Transplant Congress
Impact of Aberrant Post-Transplant Laboratory and Blood Pressure Values on Graft Survival and Racial Disparities in Kidney Transplant
D. Taber, Z. Su, J. Fleming, N. Pilch, A. Posadas, V. Rao, P. Mauldin, D. Dubay.
MUSC, Charleston, SC.
Objective: The aim of this study was to assess the impact of post-transplant lab and blood pressure (BP) clinical data on graft survival and racial…
2018 American Transplant Congress
Death-Censored Graft Failure (DCGF) Post Kidney Transplant (KTx) is Usually the Result of Rapid Loss of Function after Periods of Stability
R. Gaston,¹ L. Hunsicker,² A. Fieberg,³ A. Matas,³ The DeKaf Consortium.
¹CTI Clinical Trial & Consulting, Covington, KY; ²Int. Med., U Iowa, Iowa City, IA; ³Biostatistics and Surgery, U Minnesota, Minneapolis, MN.
Late graft dysfunction leading to clinically indicated transplant biopsy (KTxBx) is a better predictor of subsequent DCGF than baseline data and early post-transplant events (Gaston…
2018 American Transplant Congress
Outcomes of Very Old Kidney Recipients of Grafts from Very Old Donors
H. Trujillo, A. García, T. Cavero, B. Redondo, C. Moliz, T. Bada, E. González, M. Praga, A. Andrés.
Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Aims: Describe the outcomes of very old kidney recipients of grafts from very old donors. Identify pretransplant clinical factors associated with graft and recipient survival.Methods:…
2018 American Transplant Congress
The Impact of Induction Agent on Development of Febrile Neutropenia Following Kidney Transplant
G. Dube, S. Husain, D. Cohen, S. Mohan.
Medicine, Columbia University Medical Center, New York, NY.
Neutropenia is common after kidney transplant (KT), usually due to medication side effects (induction agents maintenance medications, antibiotics), and is associated with worse patient and…
2018 American Transplant Congress
Technical Challenges in Living Donor Kidney Transplantation – Diagnosis and Solutions
R. Öllinger,¹ K. Alqasim,¹ F. Klein,¹ N. Raschzok,¹ P. Ritschl,¹ S. Chopra,¹ N. Otto,² T. Denecke,³ U. Gerlach,¹ M. Schmelzle,¹ P. Reinke,² J. Pratschke.¹
¹Department of Surgery, Charité, Berlin, Germany; ²Department of Nephrology, Charité, Berlin, Germany; ³Department of Radiology, Charité, Berlin, Germany.
IntroductionDue to organ scarcity living donation is becoming a major source of kidneys for transplantation. Besides medical contraindications, anatomy of the kidneys may be a…
2018 American Transplant Congress
Diagnosis of Acute Renal Rejection Using Saliva Metabolome Analysis
H. Iwamoto,¹ M. Sugimoto,² O. Konnno,¹ Y. Kihara,¹ T. Yokoyama,¹ Y. Nakamura,¹ M. Sunamura,¹ T. Ueno.¹
¹Kidney Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan; ²Health Promotion and Preemptive Medicine, Research and Development Center for Minimally Invasive and Preemptive Medicine, Tokyo Medical University, Hachioji, Japan; ³Department of Digestive Surgery and Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.
(Objective) Wide variety of biomarker discoveries have been conducted to realize low-invasive detection of rejection after renal transplantation. Metabolomics, an omics technology to enable simultaneous…
2018 American Transplant Congress
Is Kidney Transplantation Safe in Patients over 71 Years Old?
G. Andani, P. Tulissi, M. Gropuzzo, S. Crestani, C. Vallone, U. Baccarani, D. Montanaro, A. Risaliti.
Department of Kidney & Liver Transplantation, ASUIUD, Udine, Italy.
Introduction: Kidney transplantation in elderly patients is superior over dialysis as therapy for end stage renal disease (ESRD). We analyzed different parameters to evaluate patient…
2018 American Transplant Congress
Anti-Angiotensin II Type 1-Receptor Antibodies (AT1R-Ab) Induce a Specific Phenotype of Rejection Distinct from HLA Antibody-Mediated Rejection
C. Lefaucheur,¹ D. Viglietti,¹ O. Aubert,¹ A. Philippe,² P. Halloran,³ A. Loupy,¹ D. Dragun.²
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²Medical Faculty of the Charité, Berlin, Germany; ³Alberta Transplant Applied Genomics Centre, Edmonton, Canada.
AT1R-Ab have been associated with kidney allograft rejection; however, their ability to induce a specific rejection phenotype, independent of HLA-DSAs, has not been defined.In a…
2018 American Transplant Congress
Effect of Early Attainment of Everolimus Target Trough Levels on Efficacy-Safety Outcomes in De Novo Kidney Transplant Recipients: 12-Month Results from US92 and TRANSFORM Studies
F. Shihab,¹ Y. Qazi,^1,2 V. Peddi,¹ D. Shaffer,¹ D. Kim,^1,2 K. McCague,³ D. Patel,³ S. Mulgaonkar.^1,2
¹US92 Study Group, Salt Lake City; ²TRANSFORM Study Group, East Hanover; ³Novartis Pharmaceuticals Corporation, East Hanover.
Purpose: Attainment of everolimus (EVR) target trough level (C0 3-8ng/mL) is crucial in achieving comparable efficacy-safety with EVR+reduced (r) calcineurin inhibitor regimen (CNI; tacrolimus [TAC]…