Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Frailty Assessment Pilot Study in Older Kidney Transplant Recipients
B. Abdalla, B. Hale-Durbin, J. Schaenman, C. Lee, G. Danovitch.
UCLA, Los Angeles, CA.
Older patients are more often being considered for kidney transplantation, however many candidates are on the waitlist for several years. We sought to evaluate the…
2018 American Transplant Congress
Enhancement of Intrinsic Apoptosis via Bcl-2 Inhibition Promotes Induction of Robust Mixed Chimerism and Renal Allograft Tolerance without Myelosuppression in Nonhuman Primates
T. Oura,¹ A. Dehnadi,¹ I. Rosales,¹ H. Sasaki,¹ P. Cippa,² R. Fehr,² A. Cosimi,¹ T. Kawai.¹
¹Surgery, Center for Transplantation Science, Massachusetts General Hospital, Boston, MA; ²Medicine, University of Zurich, Zurich, Switzerland.
Background: Successful induction of mixed chimerism (MC) and renal allograft tolerance has been achieved in both nonhuman primate (NHP) and man following conditioning that included…
2018 American Transplant Congress
Tacrolimus Metabolism in Subjects with Potentially Absent CYP3A Activity
A. Scheibner,¹ R. Remmel,² D. Schladt,³ W. Oetting,¹ W. Guan,⁴ B. Wu,⁴ C. Door,⁵ A. Israni,⁵ P. Jacobson.¹
¹Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN; ²Medicinal Chemistry, University of Minnesota, Minneapolis, MN; ³Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Biostatistics, University of Minnesota, Minneapolis, MN; ⁵Department of Medicine, Hennepin County Medical Center, Minneapolis, MN.
Purpose: Tacrolimus (TAC) is a well-known cytochrome P450 (CYP) 3A4 and 3A5 substrate. Common single nucleotide polymorphisms (SNPs) in these genes are significantly related to…
2018 American Transplant Congress
Inflammation in Scarred Areas (i-IF/TA): Defining the Response to Standard Treatment of T Cell-Mediated Rejection in Kidney Recipients
D. Viglietti, O. Aubert, J-.P. Duong Van Huyen, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France.
The 2017 Banff meeting has focused on the importance of defining the potential role of i-IF/TA as a component of the T cell-mediated rejection (TCMR)…
2018 American Transplant Congress
HLA Eplet Mismatch and Donor Specific Antibodies in Kidney Transplantation
S. Wan,^1,2 S. Angel de Wilde,² B. Rosales,² S. Chadban,^1,2 K. Wyburn.^1,2
¹Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²Sydney Medical School, University of Sydney, Sydney, Australia.
BACKGROUND: Although HLA matching improves graft survival in kidney transplant recipients (KTx), eplet mismatches provide higher resolution information, and could better predict the development of…
2018 American Transplant Congress
The Cost Savings of Preemptive Kidney Transplantation
P. Dean,¹ H. Heien,² K. Swanson,² B. Borah,² L. Sangaralingham,² J. Naessens,² M. Stegall.¹
¹Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; ²Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MD.
Introduction: Preemptive kidney transplantation (PreKTx) is associated with improved patient survival and quality of life. The goal of this study was to compare the costs…
2018 American Transplant Congress
Tax1bp3 is Upregulated in the Ischemia/Reperfusion Injury of Kidney
W. Qiu, J. Lin, Y. Tian.
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Objective The ischemia/reperfusion (I/R) injury plays an important role in delayed graft function (DGF) after kidney transplantation, however, the mechanism is not fully understood. Therefore,…
2018 American Transplant Congress
Global Expression Profiles of miRNA and Expression Patterns and Localization of the miR-21 in One-Hour Biopsy Specimens of Human Kidney Tansplantation from Donors after Cardiac Death
M. Kusaka,¹ N. Fukami,¹ H. Sasaki,¹ A. Kawai,¹ T. Kenmochi,² T. Ito,² R. Shiroki,¹ K. Hoshinaga.¹
¹Urology, Fujita-Health University, Toyoake/Aichi, Japan; ²Transplant Surgery, Fujita-Health University, Toyoake/Aichi, Japan.
Because of the global shortage of renal grafts, kidney transplantation (KTx) from donors after cardiac death (DCDs) is an alternative way of obtaining KTx from…
2018 American Transplant Congress
Eculizumab for the Treatment of Antibody Mediated Rejection in Kidney Transplant Recipients: A Single Center Experience
A. Chi, J. Phillips, D. Quan.
Pharmaceutical Services, UCSF Medical Center, San Francisco, CA.
BACKGROUND: Antibody mediated rejection (ABMR) accounts for 20-30% of acute rejection episodes and can affect long-term renal allograft survival. The complement system plays an active…
2018 American Transplant Congress
Clinical Heterogeneity of Early Anamnestic Donor Specific Antibody Responses in Kidney Transplantation
A. Loethen,¹ A. Lichvar,¹ S. Tremblay,¹ A. Shields,^1,2 A. Dao,¹ M. Cardi,² P. Brailey,¹ A. Girnita,¹ B. Abu Jawdeh,¹ R. Alloway,¹ E. Woodle.¹
¹U of Cincinnati, Cincinnati, OH; ²Christ Hospital, Cincinnati, OH.
Anamnestic donor specific antibody(DSA) responses in the early post-transplant period may threaten the renal transplant(RTx). We hypothesize earlier DSA detection will allow minimization of RTx…