Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Pump Resistive Index Values and Not Preimplantation Kidney Biopsy Predict Kidney Allograft Survival
J. Liu,¹ A. Blumfield,¹ M. Trivedi,¹ N. Mishra,¹ O. Mohammed,^1,2 J. Lin,³ M. Ajaimy,^1,2 J. Graham,^1,2 J. Rocca,^1,2 E. Akalin,^1,2 S. Greenstein.^1,2
¹Albert Einstein College of Medicine, Bronx, NY; ²Department of Surgery, Montefiore Medical Center, Bronx, NY; ³Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
AimTo investigate the relationship between histological findings of preimplantation kidney biopsies and pump resistive index (RI) values during machine preservation and subsequent allograft survival.MethodsWe retrospectively…
2018 American Transplant Congress
Willingness to Consider Increased Risk Donors: A Single Center Experience
V. Richards,¹ C. Johnson,¹ J. Perkins,² A. Limaye,³ L. Sibulesky.²
¹Nephrology, University of Washington, Seattle, WA; ²Surgery, University of Washington, Seattle, WA; ³Allergy and Infectious Diseases, University of Washington, Seattle, WA.
Background: The number of Public Health Service increased risk organ donors (PHS IRD) is growing, largely due to the opioid epidemic.Methods: We conducted a retrospective…
2018 American Transplant Congress
Latent Tuberculosis Diagnosis Prior to Kidney Transplantation in a High Burden Country: Improvement with Serological Tests
V. Garcia, G. Meinerz, C. da Silva, E. Keitel.
Nephrology and Kidney Transplant Department, ISCMPA, Porto Alegre, Brazil.
Introduction: Diagnosing and treating tuberculosis after kidney transplantation is challenging, and mortality is high. In an epidemiological study performed at our Center, there was an…
2018 American Transplant Congress
Clinically Relevant Variation of Donor-Derived Cell-Free DNA during Longitudinal Surveillance of Renal Allografts
M. Narayanan,¹ T. Alhamad,² D. Hiller,³ J. Yee,³ R. Woodward,³ J. Bromberg.⁴
¹Texas A&M Health Science Center, Temple, TX; ²Washington University School of Medicine, St. Louis, MO; ³CareDx, Brisbane, CA; ⁴University of Maryland School of Medicine, Baltimore, MD.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) levels >1% are associated with active rejection in renal transplant recipients. This report defines the clinically relevant variation of dd-cfDNA…
2018 American Transplant Congress
Living-Donor Preemptive Kidney Transplant Timing Calculator: An Online Decision Support Tool
M. Barah,¹ M. Kurt,² A. Khojandi,¹ B. Tanriover.³
¹Industrial and Systems Engineering, Univeristy of Tennessee, Knoxville, TN; ²Economic and Data Sciences, Merck Research Labs, North Wales, PA; ³Division of Nephrology, UT Southwestern Medical Center, Dallas, TX.
Purpose: Optimal glomerular filtration rate (GFR) and timing for living preemptive kidney transplantation (PKT) is not well studied.Method: We developed an online engine to calculate…
2018 American Transplant Congress
Everolimus with Reduced-Dose Calcineurin Inhibitor versus Mycophenolate with Standard-Dose Calcineurin Inhibitor in De Novo Kidney Transplant Recipients: Renal Function Results from the TRANSFORM Study
F. Oppenheimer,¹ C. Legendre,¹ J. Cruzado,¹ G. Russ,¹ O. Viklicky,¹ R. Oberbauer,¹ V. Garcia,¹ O. Witzke,¹ D. Kuypers,¹ R. Danguilan,¹ P. Bernhardt,² C. Sommerer.¹
¹TRANSFORM Study Group, Barcelona, Spain; ²Novartis Pharma AG, Basel, Switzerland.
Purpose: TRANSFORM (NCT01950819) is the largest study conducted in de novo kidney transplant recipients (KTxRs) to evaluate the benefit of everolimus with reduced-dose calcineurin inhibitor…
2018 American Transplant Congress
Epitope/Eplet Mismatch in Pediatric Renal Transplantation and Development of Donor Specific Antibody
R. George,¹ H. Sullivan,² R. Garro,¹ P. Winterberg,¹ B. Warshaw,¹ H. Gebel,² R. Bray.²
¹Pediatric Nephrology, Emory University & Children's Healthcare of Atlanta, Atlanta, GA; ²Dept. of Pathology, Emory Transplant Center, Emory University, Atlanta, GA.
Background: De-novo donor specific antibody (DSA) is one of the strongest independent predictors of graft loss with HLA mismatching being a major risk factor for…
2018 American Transplant Congress
Determining the Relative Immunogenicity of HLA Mismatches with Calcineurin Inhibitor Immunosuppression: An Analysis of the BENEFIT and BENEFIT-EXT Renal Transplant Cohort
V. Jucaud,¹ M. Roberts,² H. Gebel,³ R. Bray,³ M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²Immunology Biomarker Group, Bristol-Myers Squibb, Princeton, NJ; ³Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.
We studied the relative immunogenicity of HLA-A, -B, -C, -DR and -DQ MM (serological) in a cohort of 291 kidney transplant patients from the BENEFIT…
2018 American Transplant Congress
Ciprofloxacin for BK Viremia Prophylaxis in Kidney Transplant Recipients: Results of a Prospective, Randomized Controlled Trial
S. Patel, S. Kuten, R. Knight, J. Nolte, D. Nguyen, E. Graviss, L. Moore, I. Agboli, C. Pham, A. Gaber.
Houston Methodist Hospital, Houston, TX.
Fluoroquinolone (FQ) antibiotics have in vitro activity against BK virus, with several reports indicating they may reduce the risk of BK infection in kidney transplant…
2018 American Transplant Congress
Significant Anti-CMV/BKV Effect of a Modern Everolimus-Based Regimen Comparted to a Standard Tacrolimus-MPA Regimen in De Novo Kidney Transplant Recipients: ATHENA 12 Months Data on Infections
A. Hauser,¹ C. Sommerer,¹ B. Suwelack,¹ D. Dragun,¹ O. Witzke,¹ C. Hugo,¹ N. Kamar,² P. Merville,² P. Schenker,¹ M. Junge,³ F. Thaiss,¹ B. Nashan.¹
¹Athena Study Group, Germany; ²Athena Study Group, France; ³Novartis, Pharma, Germany.
The ATHENA trial was designed to compare everolimus [EVR] in combination with tacrolimus [TAC] or cyclosporine A [CyA] vs. a standard regimen of mycophenolic acid…