Articles tagged "Kidney transplantation"

2018 American Transplant Congress
No Kidney Left Behind: Are We Maximizing Utilization of Deceased Donors with AKI?
A. Bongu, R. Quillin, M. Chiles, S. Husain, M. Garcia, S. Mohan, L. Ratner.
Renal Transplantation, Columbia University, New York City, NY.
Introduction: Kidneys from donors with elevated terminal creatinine (Cr) and acute kidney injury (AKI) can be transplanted safely, yet many of these organs are not…
2018 American Transplant Congress
Early Graft Losses in National PKE Programs: Gone, but Lost Forever?
J. Verbesey,¹ A. Waterman,² J. Veale,² S. Flechner,³ B. Javaid,¹ M. Ronin,⁴ G. Hil,⁴ C. Matthew.¹
¹MedStar Georgetown Transplant Institute, Washington, DC; ²UCLA, Los Angeles, CA; ³Cleveland Clinic, Cleveland, OH; ⁴NKR, Babylon, NY.
Background: PKE increases transplants for patients who are highly sensitized or incompatible with intended living donors. Following catastrophes like primary non-function(PNF) or early graft loss,…
2018 American Transplant Congress
Urinary C5b-9 is an Independent Predictor of Graft Failure in Renal Transplant Recipients
R. Lammerts, M. Eisenga, M. Alyami, M. Seelen, M. Daha, J. van den Born, S. Bakker, S. Berger, On behalf of the COMBAT Comsortium.
Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands.
IntroductionChronic antibody-mediated rejection is thought to be the main cause of late kidney-allograft loss, involving donor-specific antibody–mediated activation of the complement system. Activation of filtered…
2018 American Transplant Congress
Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidneys from Donation after Circulatory Death: A Multi-Centre Randomised Controlled Trial
D. Summers,^1,2 L. Randle,¹ A-.M. O'Sullivan,³ R. Johnson,² D. Collett,² M. Attia,⁴ N. Ahmad,⁴ M. Clancy,⁵ M. Akyol,⁶ A. Tavakoli,⁷ N. Jamieson,³ A. Bradley,¹ C. Watson.¹
¹Cambridge University, Cambridge, United Kingdom; ²NHS Blood and Transplant, Bristol, United Kingdom; ³Cambridge University Hospitals, Cambridge, United Kingdom; ⁴Leeds Teaching Hospitals, Leeds, United Kingdom; ⁵Queen Elizabeth Hospital, Glasgow, United Kingdom; ⁶Edinburgh University, Edinburgh, United Kingdom; ⁷Manchester University Hospitals, Manchester, United Kingdom.
Introduction:Delayed graft function affects around half of all recipients of donation after circulatory death (DCD) kidneys in the UK and has a significant impact on…
2018 American Transplant Congress
Interim Results of the kSORT in the SAILOR Randomized Multicenter Trial
P. Lindner,¹ A. Shroeder,² J. Ekberg,¹ S. Hsieh,² P. Towfighi,² I. Damm,² T. Sigdel,² M. Sarwal.²
¹Sahlgrenska University Hospital, Göteborg, Sweden; ²UCSF, San Francisco.
Background: In a randomized multicenter trial of 222 renal tx recipients treated with steroid minimization and a tacrolimus, MMF based regimen, a novel gene expression…
2018 American Transplant Congress
Association of Leptin with Cystatin C in Kidney Allograft Dysfunction
A. Bera,¹ M. Watson,² N. Gana,¹ J. Karaian,¹ S. Radhakrishnan,¹ M. Subramanian,¹ D. Little,² R. Nee,² A. Chatterjee,¹ S. Rothwell,¹ H. Pollard,¹ R. Jindal,³ M. Srivastava.¹
¹Anatomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD; ²Nephrology, USU-Walter Reed, Bethesda, MD; ³Surgery, USU-Walter Reed, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring recipients of kidney allografts to predict acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft…
2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…
2018 American Transplant Congress
Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage
G. Irish,^1,2 M. Hockley,^1,2 S. Kireta,^1,2 J. Johnson,^1,2 R. Carroll.^1,2
¹Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²The Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…
2018 American Transplant Congress
The Clinical Significance of Pretransplant C1q Assay Status in Positive Crossmatch Kidney Transplantation
J. Lee,¹ D. Kim,¹ B. Park,² S. Song,³ J. Lee,⁴ Y. Jung,¹ J. Lee,¹ J. Lee,¹ B. Kim,⁵ M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Korea; ²Laboratory Medicine, Asan MEdical Center, Seoul, Korea; ³Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; ⁴Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; ⁵Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.
Background: Patients with a pretransplant donor-specific antibodies (DSA) are at higher risk for antibody-mediated rejection (AMR). However, not all DSA have the same pathogenetic potential.…
2018 American Transplant Congress
Desensitization to Facilitate Matching in a Large, National Kidney Paired Exchange Clearinghouse
C. Holscher,¹ A. Thomas,¹ K. Jackson,¹ C. Haugen,¹ M. Ronin,² A. Waterman,^3,4 A. Massie,^1,5 J. Garonzik Wang,¹ D. Segev.^1,5
¹Johns Hopkins School of Medicine, Baltimore; ²National Kidney Registry, New York; ³David Geffen School of Medicine at UCLA, Los Angeles; ⁴Terasaki Research Institute, Los Angeles; ⁵Johns Hopkins School of Public Health, Baltimore.
In kidney paired exchange (KPE) programs, the use of incompatible transplantation has been necessary to prevent long waiting times for sensitized candidates and to facilitate…