Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Circulating Wnt Pathway Factors Are Non-Invasive Biomarkers of Transplant Vascular Injury
M. Seifert,¹ A. Malone,² L. Boohaker,¹ J. Gaut,² S. Jain,² D. Brennan,^2,3 R. Mannon.¹
¹UAB School of Medicine, Birmingham; ²Washington University, St. Louis; ³Johns Hopkins University, Baltimore.
Purpose: Transplant vascular injury (TVI) is a major cause of renal allograft failure and is resistant to treatment. Non-invasive pathogenic biomarkers of TVI would provide…
2018 American Transplant Congress
Molecular Monitoring for Kidney Allograft Injury Following HLA Incompatible Transplantation
A. Jackson,¹ B. Iglehart,¹ S. Bagnasco,³ N. Desai.²
¹Medicine, Johns Hopkins University, Baltimore, MD; ²Surgery, Johns Hopkins University, Baltimore, MD; ³Pathology, Johns Hopkins University, Baltimore, MD.
Elevated donor derived cell free DNA (ddcfDNA) has been shown to correlate with allograft rejection following heart, lung, and kidney transplantation. We investigated whether sequential…
2018 American Transplant Congress
ABO-Incompatibility Lower Incidence of DSA-Induced Antibody-Mediated Rejection
D. Lee,¹ B. Kim,¹ J. KIm,¹ I. KIm,¹ M. Jeon.¹
¹Nephrology, Medicine, Maryknoll General Hospital, Busan, Republic of Korea; ²Laboratory Medicine, Maryknoll General Hospital, Busan, Republic of Korea; ³Surgery, Maryknoll General Hospital, Busan, Republic of Korea; ⁴Urology, Maryknoll General Hospital, Busan, Republic of Korea; ⁵Pathology, Maryknoll General Hospital, Busan, Republic of Korea.
Introduction:Donor-specific anti-HLA antibody (DSA) and Anti-ABO antibody are major barriers for successful kidney transplantation. Limited data are available about the existences of both DSA and…
2018 American Transplant Congress
Non Active Desensitization Protocol: Improving Access to Kidney Transplant for Hyperimmunized Patients
S. Le Bot,¹ F. Delbos,² C. Garandeau,¹ S. Malard Castagnet,² A. Cesbron,² M. Hourmant.¹
¹Nephrology and Transplantation, CHU Hôtel Dieu, Nantes, France; ²Laboratoire HLA, Etablissement Français du Sang, Nantes, France.
Hyperimmunized patients have a bad access to renal transplantation, despite national priority programs and active desensitization protocols. After having noticed that some HLA antibodies decreased…
2018 American Transplant Congress
Burden of Primary CMV Infections Remains High Despite Six Months Valganciclovir Prophylaxis in High-Risk Kidney Transplant Recipients
I. Helanterä,¹ F. Ortiz,² R. Loginov,³ L. Mannonen,³ M. Lempinen,¹ I. Lautenschlager.³
¹Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland; ²Nephrology, Helsinki University Hospital, Helsinki, Finland; ³Virology, Helsinki University Hospital, Helsinki, Finland.
A. Prophylaxis has mostly replaced preemptive therapy in CMV seronegative recipients of kidneys from seropositive donors (D+/R-). Primary infections occur commonly even after six months…
2018 American Transplant Congress
Association of Tacrolimus Adherence and Discontinuation with Sepsis Risk among Kidney Transplant Recipients
J. Donnelly,¹ P. MacLennan,¹ R. Mannon,¹ R. Saran,² J. Baddley,¹ H. Wang,³ G. McGwin, Jr.,¹ P. Muntner.¹
¹University of Alabama at Birmingham, Birmingham, AL; ²University of Michigan, Ann Arbor, MI; ³University of Texas Health Science Center, Houston, TX.
OBJECTIVE: The association between post-transplant tacrolimus exposure and sepsis risk is currently unknown. We examined the associations of tacrolimus adherence and discontinuation with sepsis risk…
2018 American Transplant Congress
The Impact of Anticoagulation Therapy Modifications during the Index Hospitalization on Clinical Outcomes in Kidney Transplant Recipients
J. Hardcopf, H. Meadows, N. Pilch, C. Perez, N. Patel, J. Fleming, H. Corbo, T. Harrison, B. O'Brien, D. DuBay, P. Baliga, D. Taber.
Medical University of South Carolina, Charleston, SC.
Background: The aim of this study was to determine whether changing anticoagulation medications during the index admission for kidney transplant (KT) is significantly associated with…
2018 American Transplant Congress
Hospitalization, Dialysis Center Type, and Disparities in ESRD Survival and Waitlist Access
R. Lynch, R. Zhang, A. Adams, R. Patzer.
Surgery, Emory University, Atlanta, GA.
Background: Excess hospitalization has been shown to reduce kidney transplant waitlist survival and likelihood of transplant. We studied hospitalization as a predictor of waitlist access…
2018 American Transplant Congress
The Providers Can't Let Go! An Analysis of an RN Driven Tacrolimus Dose Adjustment Protocol
Z. Elmaasarani, C. Mardis, L. Gylten, J. Fleming, H. Meadows, N. Patel, C. Perez, D. Taber, V. Rao, V. Rohan, P. Baliga, D. Dubay, N. Pilch.
MUSC, Charleston.
Introduction: Tacrolimus (FK) dose adjustment is frequently performed by non-MD staff. Standard protocols to evaluate the ability of non-providers to maintain pts within a goal…
2018 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Restores the Genetic Profile of Marginal Kidney Grafts Subjected to Warm Ischemia
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ S. Ganesh,¹ R. John,¹ P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,² A. Konvalinka,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹University Health Network, Toronto, ON, Canada; ²SickKids Hospital, Toronto, ON, Canada.
Background: Increasing evidence demonstrates the superiority of normothermic ex-vivo kidney perfusion (NEVKP) over cold storage (CS) for marginal renal grafts. To account for this improvement,…