Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Renal Allograft Cortical Perfusion Quantification by 3D-Arterial Spin Labeling Could Be Used to Identify Subclinical Antibody-Mediated Rejection
W. Wang,¹ J. Wen,² F. Xu,² Y. Yu,³ L. Zhang,³ Z. Liu.²
¹Nanjing Medical University, Jinling School of Medicine, Nanjing, China; ²Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, China; ³Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Background: Antibody-mediated rejection (AMR) is now the most principal post-surgical complication complicating allograft long-term survival. Therefore, its early detection before serum creatinine rises/estimated glomerular filtration…
2018 American Transplant Congress
A Machine Learning Approach for Prediction of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients
S. Kawakita,¹ A. Waterman,^1,2 M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Introduction:Delayed graft function (DGF) is an early signal of graft injury that is common in deceased donor kidney transplant (DDKT) recipients. Although we have predictive…
2018 American Transplant Congress
MeltDose Prolonged-Release Once-Daily Tacrolimus (LCPT) vs. Conventional Tacrolimus Formulations in the Initial Maintenance of De Novo Kideny Transplant Recipients across Europe: STEADY Study
K. Budde,¹ G. Piotti,² C. Procaccianti,³ G. Nicolini,³ S. Geraci,³ D. Surace.³
¹Charité Universitatsmedizin, Berlin, Germany; ²Azienda Ospedaliero-Universitaria di Parma, Parma, Italy; ³Chiesi Farmaceutici S.p.A., Parma, Italy.
Tacrolimus is an immunosuppressant drug available as a twice-daily formulation (Prograf®, IR-Tac), or as once-daily formulations (Advagraf®, PR-Tac; Envarsus®, LCPT). LCPT has shown clinical non-inferiority…
2018 American Transplant Congress
Urinary CXCL9 Monitoring to Accompany a Safe CNI-to-Belatacept Conversion in Kidney Transplant Patients
P. Malvezzi,¹ C. Fischman,² T. Jouve,¹ B. Janbon,¹ P. Heeger,² L. Rostaing,¹ P. Cravedi.²
¹Service de Néphrologie, Dialyse, Aphérèses et Transplantation, CHU Grenoble Alpes, Grenoble, France; ²Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: Converting renal transplant recipients from CNI to belatacept immunosuppression has been proposed as a strategy to limit nephrotoxicity, but it is associated with an…
2018 American Transplant Congress
Taking Specific Steps to Pursue Living Donor Kidney Transplant is Associated with Greater Odds of Having a Potential Living Donor Identified
A. Ali,¹ D. Toews,¹ N. Singh,¹ A. Ayub,¹ C. Richardson,¹ S. Dano,¹ D. Wong,¹ J. Peipert,² A. Waterman,² M. Novak,¹ I. Mucsi.¹
¹University Health Network, Toronto, ON, Canada; ²David Geffen School of Medicine, UCLA, Los Angeles, CA.
Background:When planning interventions to increase living donor kidney transplant (LDKT), it is important to understand what actions can patients take that are associated with an…
2018 American Transplant Congress
Enhanced Recovery after Renal Transplant Surgery Using a Transversus Abdominis Plane Block is Associated with Decreased Hospital Length of Stay
D. Peramunage, D. Auyong, C. Kuhr, J. Brandenberger, N. Cowan, N. Hanson.
Virginia Mason Medical Center, Seattle, WA.
BACKGROUNDThe transversus abdominis plane (TAP) block reduces pain and opioid consumption following renal transplant surgery, but its impact on hospital length of stay (LOS) remains…
2018 American Transplant Congress
Novel Approach to Molecular Testing Using Routine Diagnostic Tissue
P. Herzyk,¹ F. McMonagle,¹ P. Shiels,¹ S. Coley.²
¹University of Glasgow, Glasgow, United Kingdom; ²Columbia University, New York.
Currently, molecular diagnostics in kidney transplantation requires dedicated fresh tissue. This requirement limits use in mainstream clinical settings due to perceived increased patient risk in…
2018 American Transplant Congress
Characteristics of Polyomavirus Nephropathy in Renal Transplant Recipient in China: 10 Year Experience
G. Huang, X. Chen, L. Chen.
Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Till now regular BKV screening after kidney transplantation is not performed in many transplant centers in China. As several noninvasive methods were available in…
2018 American Transplant Congress
Clostridium difficile Recurrence in Abdominal Organ Transplant Recipients: Metronidazole versus Oral Vancomycin
A. Moorman,¹ S. Todd,¹ G. Lyon III,² H. Triemer.¹
¹Department of Pharmaceutical Services, Emory University Hospital, Atlanta, GA; ²Division of Infectious Diseases, Emory University, Atlanta, GA.
Clostridium difficile infection (CDI) is one of the most common hospital-acquired infections among the general inpatient population with recurrence rates of 20-30% despite appropriate treatment.…
2018 American Transplant Congress
Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation
J. Kwun,¹ B. Ezekian,¹ M. Manook,¹ J. Park,¹ J. Yoon,¹ J. Sloan-Lancaster,² C. Fortier,³ P. Rao,⁴ S. Knechtle.¹
¹Surgery, Duke University, Durham, NC; ²Eli Lilly and Company, Indianapolis, IN, Canada; ³PRCL Research Inc, Montreal, QC, Canada; ⁴Synta Pharmaceuticals Inc., Lexington, MA.
[Background] Long-term administration of calcineurin inhibitors (CNIs) successfully controls rejection of transplanted organs. However, the chronic use of these drugs causes organ damage often resulting…