Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Circulating Wnt Pathway Factors Are Non-Invasive Biomarkers of Transplant Vascular Injury
M. Seifert,¹ A. Malone,² L. Boohaker,¹ J. Gaut,² S. Jain,² D. Brennan,^2,3 R. Mannon.¹
¹UAB School of Medicine, Birmingham; ²Washington University, St. Louis; ³Johns Hopkins University, Baltimore.
Purpose: Transplant vascular injury (TVI) is a major cause of renal allograft failure and is resistant to treatment. Non-invasive pathogenic biomarkers of TVI would provide…
2018 American Transplant Congress
Molecular Monitoring for Kidney Allograft Injury Following HLA Incompatible Transplantation
A. Jackson,¹ B. Iglehart,¹ S. Bagnasco,³ N. Desai.²
¹Medicine, Johns Hopkins University, Baltimore, MD; ²Surgery, Johns Hopkins University, Baltimore, MD; ³Pathology, Johns Hopkins University, Baltimore, MD.
Elevated donor derived cell free DNA (ddcfDNA) has been shown to correlate with allograft rejection following heart, lung, and kidney transplantation. We investigated whether sequential…
2018 American Transplant Congress
ABO-Incompatibility Lower Incidence of DSA-Induced Antibody-Mediated Rejection
D. Lee,¹ B. Kim,¹ J. KIm,¹ I. KIm,¹ M. Jeon.¹
¹Nephrology, Medicine, Maryknoll General Hospital, Busan, Republic of Korea; ²Laboratory Medicine, Maryknoll General Hospital, Busan, Republic of Korea; ³Surgery, Maryknoll General Hospital, Busan, Republic of Korea; ⁴Urology, Maryknoll General Hospital, Busan, Republic of Korea; ⁵Pathology, Maryknoll General Hospital, Busan, Republic of Korea.
Introduction:Donor-specific anti-HLA antibody (DSA) and Anti-ABO antibody are major barriers for successful kidney transplantation. Limited data are available about the existences of both DSA and…
2018 American Transplant Congress
Non Active Desensitization Protocol: Improving Access to Kidney Transplant for Hyperimmunized Patients
S. Le Bot,¹ F. Delbos,² C. Garandeau,¹ S. Malard Castagnet,² A. Cesbron,² M. Hourmant.¹
¹Nephrology and Transplantation, CHU Hôtel Dieu, Nantes, France; ²Laboratoire HLA, Etablissement Français du Sang, Nantes, France.
Hyperimmunized patients have a bad access to renal transplantation, despite national priority programs and active desensitization protocols. After having noticed that some HLA antibodies decreased…
2018 American Transplant Congress
Burden of Primary CMV Infections Remains High Despite Six Months Valganciclovir Prophylaxis in High-Risk Kidney Transplant Recipients
I. Helanterä,¹ F. Ortiz,² R. Loginov,³ L. Mannonen,³ M. Lempinen,¹ I. Lautenschlager.³
¹Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland; ²Nephrology, Helsinki University Hospital, Helsinki, Finland; ³Virology, Helsinki University Hospital, Helsinki, Finland.
A. Prophylaxis has mostly replaced preemptive therapy in CMV seronegative recipients of kidneys from seropositive donors (D+/R-). Primary infections occur commonly even after six months…
2018 American Transplant Congress
Prevention of Hepatitis B Virus Reactivation in HBsAg-Positive Renal Transplant Recipients with Rituximab Treatment
J. Choi, J. Jung, H. Kwon, S. Shin, Y. Kim, D. Han.
Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Background: The risk of Hepatitis B virus (HBV) reactivation under immunosuppressant has been well known. Hepatitis B virus reactivation increase patient mortality and graft failure…
2018 American Transplant Congress
Changes in Vitamin D Levels after Kidney Transplantation
E. Lum, K. Phonphok, N. Datta, S. Bunnapradist.
Nephrology, UCLA David Geffen School of Medicine, Los Angeles, CA.
IntroductionLow levels of serum vitamin D are common and associated adverse renal outcomes. The frequency of hypovitaminosis D following kidney transplantation (KT) is not well…
2018 American Transplant Congress
Qualitative Analysis of Facebook Posts Created via the Donor Application
J. Konel, S. Weeks, K. Kumar, D. Helfer, D. Segev, J. Garonzik Wang, M. Henderson, A. Cameron.
Johns Hopkins, Baltimore.
The Donor App is a smartphone app that helps transplant candidates create a Facebook (FB) post telling their story about organ failure and their need…
2018 American Transplant Congress
Innovative Strategies to Accommodate Increased Patient Volume in an Outpatient Transplant Infusion Center
J. Estrada, M. Tyrell, J. Choi, J. Jagolino, S. Jordan.
Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA.
Purpose: To accommodate the increasing volume of patients scheduled for infusions at the Comprehensive Transplant Center(CTC) Infusion suite. It began as a two chair unit…
2018 American Transplant Congress
A Proteomic Analysis of Kidneys Subjected to Normothermic Ex Vivo Kidney Perfusion (NEVKP) Demonstrates That Metabolism is an Important Determinant of Kidney Function Following Warm Ischemia
A. Konvalinka,^1,4 T. Tokar,² S. Reid,⁴ P. Urbanellis,⁴ M. Hamar,⁴ M. Kaths,⁴ I. Jurisica,² L. Robinson,^4,3 M. Selzner.^4,5
¹Medicine/Nephrology, University Health Network, Toronto, ON, Canada; ²Medical Biophysics/Computer Science, University of Toronto, Toronto, ON, Canada; ³Pediatrics/Nephrology, Hospital for Sick Children, Toronto, ON, Canada; ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁵Surgery/General Surgery, University Health Network, Toronto, ON, Canada.
Kidney transplantation reduces mortality compared to staying on dialysis, incentivizing the use of marginal kidneys in face of organ shortage. These marginal kidneys after cardiocirculatory…