Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Presence of Donor Specific Antibodies is Associated with Accelerated Podocyte Detachment
A. Naik, J. Aqeel, D. Cibrik, M. Samaniego, S. Wang, M. Chowdhury, F. Afshinnia, R. Wiggins.
University of Michigan, Ann Arbor; University of Kansas, Kansas City.
Introduction: Both indication and 10-yr surveillance biopsy data point to the important role of progressive glomerular disease in intermediate and long-term allograft outcomes. As all…
2018 American Transplant Congress
TORC1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
B. Al Dulaijan, S. Eskandari, J. Karnyski, J. Assaker, S. Cai, A. Mansouri, M. Mohamed, J. Azzi.
Transplantation Research Center, BWH, Harvard Medical School, Boston, MA.
The safety and efficacy of adoptive transfer of regulatory T cells (Tregs) are being extensively investigated in ongoing clinical trials. However, these trials have been…
2018 American Transplant Congress
Offspring Living Kidney Donors Should Not Be Ruled Out
X. Luo, A. Massie, C. Holscher, D. Segev.
Johns Hopkins University, Baltimore.
A recent study (AJT, January 2018) suggested that kidneys from offspring live donors conferred worse post-transplant outcomes than non-offspring live donors, and advocated selecting non-offspring…
2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
H. Higuchi,^1,2 K. Hotta,¹ D. Iwami,¹ J-.J. Jiang,² D. Kamimura,² Y. Arima,² T. Atsumi,² Y. Takada,^1,2 H. Harada,³ M. Murakami,² N. Shinohara.¹
¹Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ²Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ³Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.
［Background］We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…
2018 American Transplant Congress
Urinary C-X-C Motif Chemokines 13 is a Noninvasive Biomarker of Antibody-Mediated Renal Allograft Rejection
D. Chen, J. Chen.
Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Background: Since acute rejection remains one of the major complications which necessitate periodic surveillance, noninvasive diagnostic/prognostic methods are preferred by renal transplant recipients. Here we…
2018 American Transplant Congress
Impact of Pretransplant Donor-Specific Antibodies on Kidney Allograft Recipients with Negative Flow Cytometry Crossmatches
H. Kwon, Y. Kim, J. Choi, S. Shin, J. Jung, M. Cho, J. Kim, D. Han.
Asan Medical Center, Seoul, Korea.
This study evaluated the impact of DSA on clinical outcomes in KT recipients negative on FCXM. Of 575 consecutive patients who underwent living donor KT…
2018 American Transplant Congress
Efficacy of IVIG + Rituximab Desensitization Therapy on HLA Antibodies is Independent of HLA Loci
X. Zhang,¹ S. Jordan.²
¹HLA and Immunogenetics Laboratory, Comprehensive Transplant Center/ Cedars-Sinai Health Systems, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Aim: Desensitization with the intravenous immunoglobulin (IVIG) and Rituximab therapy is commonly used to promote transplant of highly sensitized patients. It is suggested that HLA-DQ…
2018 American Transplant Congress
Fosfomycin vs Other Antibiotics for UTI after Kidney Transplant
O. Mgbako,¹ J-.E. Ha,¹ N. Topilow,² E. Min,¹ D. Taupin,¹ V. Tatapudi,¹ B. Gelb,¹ S. Hochman.¹
¹NYU Langone Health, New York; ²Mt Sinai West, New York.
Urinary tract infection (UTI) is a frequent infectious complication in kidney transplant recipients (KTRs). Antibiotic resistance is common among urine bacterial isolates in this population.…
2018 American Transplant Congress
Early Infectious Outcomes of Older Adults Undergoing Kidney Transplantation (KT). A Case Control Study
M. Hemmersbach-Miller,^1,2 K. Schmader.³
¹Infectious Diseases, Duke University Medical Center, Durham, NC; ²Duke Clinical Research Institute, Durham, NC; ³Geriatrics, Duke University Medical Center, Durham, NC.
Study Purpose: Our aim was to investigate if among older KT recipient, the types of infections, number of rejections, graft and patient survival in the…
2018 American Transplant Congress
The Impact of Immunosuppression on Mineral Metabolism One Year after Kidney Transplantation: Differences between a Mycophenolate-Based Regimen versus an mTOR-Inhibitor-Based One
D. Cucchiari,¹ S. Karam,² P. Ventura-Aguiar,¹ F. Diekmann,¹ J. Torregrosa.¹
¹Renal Transplant Unit, Hospital Clinic, Barcelona, Spain; ²Department of Medicine, Saint George Hospital University Medical Center, Beirut, Lebanon.
INTRODUCTION: after kidney transplantation, a substantial amount of patients still suffer from Mineral Bone Disorder. The role of different immunosuppressive therapies on mineral metabolism in…