Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Prevalence of Frailty among Kidney Transplant Recipients in the United States
A. Thomas,¹ A. Shaffer,¹ H. Ying,¹ S. Norman,² D. Segev,¹ M. McAdams-DeMarco.¹
¹JHU, Baltimore; ²University of Michigan, Ann Arbor.
Frailty, a measure of physiologic reserve, increases the risk of delayed graft function, longer length of stay, early hospital readmission, immunosuppression intolerance, and mortality among…
2018 American Transplant Congress
Anti-TIRC7 Antibody Acts Synergistically with Tacrolimus in Promoting Graft Survival in a Rat Kidney Transplant Model
S. Tullius,¹ Y. Kumamoto,² U. Nalan.³
¹Department of Medicine, Brigham and Women's Hospital, Boston, MA; ²Department of Surgery, Kitasato University School of Medicine, Kanagawa, Sagamihara, Japan; ³Institute for Medical Immunology, University Hospital Charite, Berlin, Germany.
Background: Induction of T cell immune response c-DNA (TIRC7) is restricted to activated lymphocytes. Modulation of TIRC7 signalling prevents immune activation specifically at the site…
2018 American Transplant Congress
Extended Experience Using Tocilizumab (Anti-IL6R, TCZ) for the Treatment of Chronic Antibody Mediated Rejection (CABMR)
J. Choi,¹ O. Aubert,² S. Louie,¹ N. Ammerman,¹ A. Vo,¹ A. Peng,¹ E. Huang,¹ R. Najjar,¹ D. Puliyanda,¹ S. Sethi,¹ M. Haas,¹ K. Lim,¹ A. Loupy,² S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Paris Translational Center for Organ Transplantation, Paris, France.
Introduction: Disruption of the IL-6/IL-6R pathways may have benefits in treating allograft rejection. We reported our experience with anti-IL-6R (TCZ) as a treatment for CABMR…
2018 American Transplant Congress
Modifiable Causes of Racial Disparities in Living Donor Kidney Transplant
J. Beaumont,¹ J. Peipert,^1,2 C. Anderson,² A. Paiva,³ M. Robbins,³ A. Waterman.^1,2
¹Terasaki Research Institute, Los Angeles, CA; ²Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA; ³Department of Psychology, University of Rhode Island, Kingston, RI.
Racial disparities between White and non-White patients in receiving living donor kidney transplants (LDKT) are large and widespread. Yet, the causes of this disparity are…
2018 American Transplant Congress
Evaluating the Impact of Pre-Transplant Malignancy on Outcomes after Kidney Transplantation: A National Database Analysis over a Twenty-Two Year Period
D. Livingston-Rosanoff, L. Wilke, G. Leverson, D. Foley.
Dept. of Surgery, University of Wisconsin, Madison, WI.
Introduction: Patients with a history of malignancy prior to kidney transplantation are known to develop more post-transplant malignancies and have inferior outcomes. However, there have…
2018 American Transplant Congress
Effect of Acute Vascular Inflammation (v) on Death Censored Graft Failure (DCGF) Following Kidney Transplant (KTx)
J. Grande,¹ L. Hunsicker,² R. LeDuc,³ A. Matas, The DeKAF Consortium.
¹Pathology, Mayo Clinic, Rochester, MN; ²Int. Med., U Iowa, Iowa City, IA; ³Biostatistics and Surgery, U Minnesota, Minneapolis, MN.
The impact of acute vascular inflammation in acute cellular or humoral rejection following KTx, and the effect of isolated vascular inflammatory lesions on late DCGF,…
2018 American Transplant Congress
Antihypertensive Medication Use after Kidney Transplant: Practice Variation and Clinical Outcomes
H. Yamout,^1,2 R. Ouseph,¹ M. Schnitzler,¹ H. Xiao,¹ V. Dharnidharka,³ A. Naik,⁴ N. Lam,⁵ F. Koraishy,^1,2 H. Randall,¹ D. Brennan,⁶ D. Segev,⁶ B. Kasiske,⁷ G. Hess,⁸ K. Lentine.¹
¹Saint Louis Univ, St. Louis; ²St. Louis VA, St. Louis; ³Washington Univ, St. Louis; ⁴Univ Michigan, Ann Arbor, Canada; ⁵Univ Alberta, Edmonton; ⁶Johns Hopkins, Baltimore; ⁷Hennepin County, Minneapolis; ⁸Symphony Health, Conshohocken.
Hypertension is common among kidney transplant (KTx) recipients, but the impact of antihypertensive medication (AHM) choice on patient and graft outcomes is not well defined.We…
2018 American Transplant Congress
Development of an Individualized Online Shared Decision Making Tool for Kidney Transplant Candidates
A. Hart,^1,2,3 M. Bruin,¹ S. Chu,¹ M. Partin,¹ A. Matas,¹ C. John,¹ A. Israni.^1,2,3
¹University of Minnesota, Minneapolis; ²Scientific Registry of Transplant Recipients, Minneapolis; ³Hennepin County Medical Center, Minneapolis.
Background: Inadequate knowledge hinders informed decision making in kidney transplant candidates. We conducted qualitative interviews and focus groups with patients and providers to inform development…
2018 American Transplant Congress
Impact of Rapid Discontinuation of Prednisone on Kidney Transplant Outcomes in At-Risk Subpopulations: An OPTN/SRTR Analysis
D. Vock,¹ A. Matas.²
¹Public Health, U of MN, Mpls, MN; ²Surgery, U of MN, Mpls, MN.
Objective: Successful RDP (rapid discontinuation of prednisone <1 week post-tx) after kidney transplant (KTx) has been reported for low-risk populations. We studied the impact of…
2018 American Transplant Congress
Non-Invasive Diagnostic of Renal Allograft Rejection via Urine Metabolites Using NMR-Spectroscopy
M. Banas,¹ S. Neumann,² P. Pagel,² D. Chittka,¹ V. Pfahlert,² B. Banas.¹
¹Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; ²numares HEALTH, Regensburg, Germany.
Introduction and BackgroundPost-transplant surveillance for acute rejection is typically based on regular monitoring of serum creatinine levels and consecutive biopsies upon functional renal impairment. Attempts…