Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Presence of Chronic Vascular Lesions on Allograft Biopsy is Associated with Greater Improvement in Renal Function after Conversion from Tacrolimus to Belatacept
M. Perez-Saez,^1,2 B. Yu,¹ A. Uffing,¹ N. Murakami,¹ J. Azzi,¹ S. El Haji,³ S. Gabardi,³ L. Riella.¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Servicio de Nefrologia, Hospital del Mar, Barcelona, Spain; ³Pharmacy Services, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Background: Conversion from tacrolimus to belatacept has been shown to be beneficial for an increasing number of kidney transplant (KT) patients. However, predicting factors for…
2018 American Transplant Congress
Prolonged-Release Tacrolimus Dosing in De Novo Kidney Transplantation: Randomized, Open-Label, Pilot Study
Y. Kim,¹ Y. Chiang,² S. Kim,³ M. Kim,⁴ S. Park,⁵ S. Wu,⁶ K. Horita,⁷ Y. Nakashima,⁷ H. Jiang,⁸ D. Han.¹
¹Asan Medical Center, Seoul, Korea; ²Chang Gung Memorial Hospital-Linkou, Taoyuan City, Taiwan; ³Samsung Medical Center, Seoul, Korea; ⁴Severance Hospital, Seoul, Korea; ⁵Dongsan Medical Center, Daegu, Korea; ⁶Tri-Service General Hospital, Taipei City, Taiwan; ⁷Astellas Pharma, Inc., Tokyo, Japan; ⁸Astellas Pharma, Inc., Maao, Singapore.
A multicenter, randomized, open-label, parallel-group, pilot, 52-wk study in Asian countries that assessed renal function, efficacy, and safety of low vs standard-dose prolonged-release tacrolimus (PRT)…
2018 American Transplant Congress
Outcomes in Living Kidney Transplant Donor and Recipient Operations with Same vs. Different Surgeons
J. Sokolich,¹ J. Buggs,¹ D. Mahon,² E. Rogers,³ V. Bowers.¹
¹Transplant Surgery, Tampa General Medical Group, Tampa General Hospital, Tampa, FL; ²Pre-Med Undergraduate, University of South Florida, Tampa, FL; ³Transplant Research, Tampa General Hospital, Tampa, FL.
Introduction: Living Kidney Transplantation (LKT) has provided a means of increasing the organ pool for patients with end-stage renal disease (ESRD). Surgical practices vary regarding…
2018 American Transplant Congress
Impact of an Anastomosis Time on Transplant Outcomes in Deceased Donor Kidney Transplantation
K. Jeong, H. Jung, J. Choi, J-.H. Lim, J. Choi, J-.H. Cho, S-.H. Park, Y-.L. Kim, C-.D. Kim.
Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
Background: It is known that the increase in anastomosis time (AT) in deceased donor kidney transplantation (DDKT) is associated with increased incidence of delayed graft…
2018 American Transplant Congress
Role of BK Virus-Specific T Cell Immune Monitoring for BK Virus-Associated Nephropathy in Kidney Transplant Recipients
J. Bruminhent,¹ S. Srisala,² C. Klinmalai,³ S. Pinsai,¹ S. Watcharananan,¹ S. Kantachuvessiri,⁵ S. Hongeng,⁴ N. Apiwattanakul.³
¹Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ²Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ³Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ⁴Division of Hematology and Oncology, Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ⁵Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: Reduced immunosuppression in a key therapy for BK virus (BKV)-associated nephropathy (BKVAN) in kidney transplant (KT) recipients. A study of immune monitoring against BKV…
2018 American Transplant Congress
Clinical Trials and Electronic Health Records
J. Chen, S. Bhattachrya, M. Sirota, M. Sarwal, A. Butte.
Institute for Computational Health Sciences, University of California San Francisco, San Francisco; Deaprtment of Surgery, University of California San Francisco, San Francisco.
Background. Ethnic and gender disparities in solid organ transplantation (tx) have social and clinical implications.General disparities for donor access and complications within clinical-trial, national and…
2018 American Transplant Congress
Dehydropeptidase-Iinhibitor Reduces Tacrolimus-Induced Kidney Injury by Anti-Oxidative and Anti-Apoptotic Effect
K. Luo,¹ S. Lim,¹ J. Il,¹ Y. Shin,¹ E. Ko,^1,2 B. Chung,^1,2 H. Hwang,^1,2 C. Yang.^1,2
¹Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea.
Background:Cilastatin is an inhibitor of dehydropeptidase-I which enhances the antibacterial activity of imipenem.Dehydropeptidase I is associated with not only the metabolism of the enzyme but…
2018 American Transplant Congress
Implementation of Intensive Standardized Follow-Up in Kidney Transplant Recipients
A. Crane, M. Eltemamy, T. Coy, P. Babbar, A. Sun, D. Jacobsen, M. Ponziano, E. Poggio, A. Wee, R. Fatica, V. Krishnamurthi.
Cleveland Clinic, Cleveland.
Introduction & Objective: Kidney transplant recipients have higher rates of prolonged hospitalization and readmission rates. We aimed to identify modifiable predictors of 30-day readmission and…
2018 American Transplant Congress
Donor Specific Antibodies and Clinical Outcomes in Kidney Transplant Recipients
S. Wan,^1,2 S. Chadban,^1,2 K. Wyburn.^1,2
¹Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²Sydney Medical School, University of Sydney, Sydney, Australia.
BACKGROUND: Donor specific antibodies (DSA) have been implicated in the development of acute rejection (AR) and graft dysfunction in kidney transplant recipients (KTx). However, limited…
2018 American Transplant Congress
Successful Utilization of Deceased Donor Kidney Allografts with KDPI>85 in Older Recipients
A. Nickkholgh,¹ A. Agarwal,¹ A. Nishio Lucar,² K. Brayman,¹ A. Doyle,² J. Oberholzer.¹
¹Dept. of Surgery, University of Virginia Health System, Charlottesville, VA; ²Dept. of Internal Medicine, University of Virginia Health System, Charlottesville, VA.
Background: High kidney donor profile index (KDPI >85%) organs can grant earlier access to transplantation particularly for those who are frail, have limited waiting time…