Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Leveraging Single-Cell Signatures in Kidney Transplant Biopsies Uncovers Immunological Heterogeneity Within Rejection Phenotypes
J. Callemeyn¹, B. Lamarthée¹, P. Koshy², T. Debyser³, E. Van Loon¹, A. Franken⁴, T. Van Brussel⁴, I. Arijs⁴, D. Lambrechts⁴, M. Rabant⁵, A. Senev¹, T. Vaulet⁶, C. Tinel¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, ³Faculty of Medicine, KU Leuven, Leuven, Belgium, ⁴Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, ⁵Necker-Enfants Malades Institute, Institut national de la santé et de la recherche médicale (Inserm), Université de Paris, Paris, France, ⁶ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: Rejection of the kidney allograft is hallmarked by the accumulation of inflammatory cells within the renal architecture, leading to microvascular or tubulointerstitial inflammation. However,…
2022 American Transplant Congress
Final Flow and Resistance During Cold Pulsatile Perfusion Preservation Do Have Value in Prediction of Deceased Donor Graft Survival After Adjusting for KDPI
D. S. Keith, E. Lessmann
Kidney Transplant, Sacred Heart Hospital, Pensacola, FL
*Purpose: To determine whether cold pulsatile perfusion preservation (CPPP) parameters of flow and resistance provide additional data regarding deceased donor kidney graft survival after adjusting…
2022 American Transplant Congress
Early Outcomes Since Implementation of New Kidney Allocation System
K. Shah, F. Siddiqui, P. N. Chotai, A. Logan, A. Schenk, K. Washburn, A. Limkemann
Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: The new Kidney allocation system (nKAS) implemented for optimization of organ placement. Like other organ allocation systems, kidney has been redefined from donation service…
2022 American Transplant Congress
Impact of Kidney Allocation Change on Low Volume Kidney Transplant Centers
S. Nagaraju¹, S. Vaishnav¹, S. A. Deslich², S. Hanna¹, A. Jones³, J. B. Africa¹
¹Renal Transplant, Charleston Area Medical Center, Charleston, WV, ²Research Associate Senior, Health Services & Outcomes Rsc, Charleston Area Medical Center, Charleston, WV, ³Charleston Area Medical Center, Charleston, WV
*Purpose: Effective March 15, 2021, the OPTN launched a new policy for matching kidney and pancreas transplant candidates with organs from deceased donors. The new…
2022 American Transplant Congress
Transplant Coordinator Time Saved (TCTS) Through a Hybrid On Call Team for Deceased Donor Kidney and Pancreas Transplant Organ Offers
K. Ko, C. Gregory, J. Le, A. Lutrick, U. Reddy
Division of Kidney and Pancreas Transplantation, UC Irvine, Orange, CA
*Purpose: The purpose of this analysis was to estimate transplant coordinator time saved (TCTS) through the implementation of a hybrid on call team. Historically, transplant…
2022 American Transplant Congress
Reassessment of Previous Kidney Discards from a Single Large Organ Procurement Organization
S. Bunnapradist¹, T. Seto², A. Cohen², T. Rosenthal¹, G. Danovitch¹
¹David Geffen School of Medicine, Los Angeles, CA, ²One Legacy, Los Angeles, CA
*Purpose: After deceased donor kidneys are recovered, they are offered according to UNOS policy and are discarded if no centers in the country would use…
2022 American Transplant Congress
Identical Kidneys Are Discarded at Higher Rates When Labeled as High KDPI
C. Crannell, J. Perkins, C. Kling
University of Washington, Seattle, WA
*Purpose: The kidney donor risk index (KDRI) and percentile conversion kidney donor profile index (KDPI) were introduced with the Kidney Allocation System (KAS) to provide…
2022 American Transplant Congress
Outcomes of Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists in Diabetic Kidney Transplant Recipients
T. S. Mahmoud¹, J. Yagan¹, A. Hasan², O. Gheith¹, M. Mostafa¹, S. Rida¹, N. El-Serwy¹, M. Shaker¹, M. Khalid¹, P. Nair¹, T. Alotaibi¹
¹Nephrology, Organ Transplant Center, Kuwait, Kuwait, ²Immunometabolism, Dasman Diabetes Center, Kuwait, Kuwait
*Purpose: The impact of the new glucose lowering therapies, sodium-glucose cotransporter 2 inhibitors (SGLT2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA), on managing patients with type…
2022 American Transplant Congress
Validation of a Prediction System for Risk of Allograft Loss (iBOX) in Pediatric Kidney Transplant Recipients
J. Hogan¹, G. Divard², R. Garro³, O. Boyer⁴, M. Seifert⁵, J. Smith⁶, B. Toenshoff⁷, K. Twombley⁸, B. Warady⁹, P. Weng¹⁰, R. Zaar¹¹, R. Patzer¹², A. Loupy²
¹Pediatric Nephrology, Robert Debré Hospital, APHP, Paris, France, ²Paris Transplant Group, INSERM, Paris, France, ³Pediatric Nephrology, Children Healthcare of Atlanta, Atlanta, GA, ⁴Pediatric Nephrology, Necker Hospital, Paris, France, ⁵UAB School of Medicine, Birmingham, AL, ⁶Pediatric Nephrology, Seattle Children, Seattle, WA, ⁷University Children's Hospital, Heidelberg, Germany, ⁸Medical University of South Carolina, Charleston, SC, ⁹Childrens Mercy Hospital, Kansas City, MO, ¹⁰Pediatric Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ¹¹Pediatric Nephrology, Le Bonheur Children's Hospital, Memphis, TN, ¹²Emory Transplant Center, Emory University, Atlanta, GA
*Purpose: Kidney allograft loss is a common cause of end-stage renal disease but accurate prediction models of kidney allograft loss are lacking in children. The…
2022 American Transplant Congress
Comparison of Immediate-Release Tacrolimus to Envarsus XR on the Development of Donor Specific Antibodies in Kidney Transplant Recipients
R. A. Arora, C. Kane, K. Lang, M. Kapugi, C. D'Agostino, K. Cunningham, S. H. Park
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Major causes of de novo development of donor specific antibodies (DSA) after kidney transplant include medication noncompliance and immunosuppression minimization or elimination that may…