Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Longitudinal Analysis of Community Respiratory Virus Infection in Kidney Transplant Recipients
O. Beaird, K. Phonphok, S. Chandrasekaran, O. Garner, S. Bunnapradist, J. Schaenman.
David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Purpose: Community respiratory viruses (CRVs) cause significant morbidity and mortality in solid organ transplant recipients, but little is known about the epidemiology of CRV infections…
2018 American Transplant Congress
CMV-Specific Cell-Mediated Immunity after Valgancyclovir Prophylaxis Predicts Late Onset CMV Infection in Kidney Transplant Patients
M. Jarque,¹ E. Crespo,¹ E. Melilli,² A. Manonelles,² N. Montero,² S. Luque,¹ J. Cruzado,^1,2 J. Grinyo,^1,2 O. Bestard.^1,2
¹Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Nephrology Department, Bellvitge University Hospital, Barcelona, Spain.
Background: There is currently no means to predict late-onset CMV infection after a long course of post-transplant Valgancyclovir prophylaxis therapy and its development still negatively…
2018 American Transplant Congress
Thymoglobulin Induction Decreases Risk of Death in HLA-Sensitized Kidney Recipients
C. Loheac, O. Aubert, M. Assayag, D. Viglietti, C. Lefaucheur, A. Loupy.
Paris Translational Research Center for Organ Transplantation, Paris, France.
Anti-thymocyte globulin (ATG) is currently the preferential induction treatment in kidney recipients at high risk for allograft rejection. However, no study has evaluated the benefits…
2018 American Transplant Congress
BK Polyomavirus (BKPyV)-Specific T Cells as a Diagnostic and Prognostic Marker for BKPyV-Infections after Pediatric Kidney Transplantation
T. Ahlenstiel-Grunow,¹ M. Sester,² U. Sester,³ L. Pape.¹
¹Pediatric Nephrology, Hannover Medical School, Hannover, Germany; ²Transplant and Infection Immunology, Saarland University, Homburg, Germany; ³Internal Medicine IV, Saarland University, Homburg, Germany.
After kidney transplantation (KTx) immunosuppressive therapy causes an impaired cellular immune defense resulting in an increased risk of BKPyV-nephropathy (BKPyVAN). Prognostic markers for the outcome…
2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in a Non-Human Primate Identifies Inflammation as a Risk Factor in Chronic Antibody Mediated Rejection
R. Smith,¹ B. Adam,² A. Rosales,¹ M. Matsunami,³ T. Oura,³ B. Cosimi,³ T. Kawai,³ M. Mengel,² R. Colviin.¹
¹Pathology, Massachusetts General Hospital, Boston, MA; ²Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ³Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionChronic alloantibody mediated rejection (CAMR) is a major risk factor in renal allografts. Some inflammation is commonly identified within CAMR, though mostly low grade, and…
2018 American Transplant Congress
Long-Term Kidney Transplant Survival after Deceased-Donor Acute Kidney Injury
I. Hall, E. Akalin, J. Bromberg, M. Doshi, M. Harhay, Y. Jia, S. Mansour, S. Mohan, T. Muthumkumar, P. Reese, B. Schröppel, P. Singh, H. Thiessen-Philbrook, F. Weng, C. Parikh.
Deceased Donor Study Consortium, New Haven, CT.
Purpose: Acute kidney injury (AKI) occurs frequently in deceased donors and is associated with organ discard. Prior studies indicate an association between donor AKI and…
2018 American Transplant Congress
Robotic Kidney Transplantation in Obese Recipients: The New Standard?
I. Tzvetanov, C. Di Bella, K. Tulla, M. Spaggiari, F. Gheza, P. Di Cocco, J. Oberholzer, E. Benedetti.
Surgery, University of Illinois, Chicago, IL; Surgery, University of Virginia, Virginia, VA.
Introduction: Obese recipients could potentially benefit from the introduction of minimally invasive techniques for kidney transplantation. We have introduced robotic kidney transplantation for our obese…
2018 American Transplant Congress
A Transcriptomic Signature in PBMC from Kidney Transplant Recipients at Baseline Predicts Early Acute Rejection
W. Zhang,¹ Z. Yi,¹ P. Cravedi,¹ L. Li,¹ K. Keung,² C. Wei,¹ M. Menon,¹ J. Dudley,¹ P. O'Connell,² B. Murphy.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; ²Medicine, The University of Sydney, Sydney, Australia.
Background: Our multi-center study (Genomics of Chronic Allograft Rejection, GoCAR) revealed that early acute rejection (EAR, developed before 6 months post-transplant) is associated with later…
2018 American Transplant Congress
Proton-Pump Inhibitor Utilization is Associated with Higher Rates of Clostridium difficile Infection and Hypomagnesemia after Kidney Transplant
G. Kipp,² K. Dancsecs,¹ A. Lapping.¹
¹School of Pharmacy, Duquesne University, Pittsburgh, PA; ²Abdominal Transplant, Allegheny General Hospital, Pittsburgh, PA.
The purpose of this project was to identify how many kidney transplant patients were taking a proton pump inhibitor (PPI) after kidney transplant at our…
2018 American Transplant Congress
Intragraft Gene Expression Differentiates Polyomavirus Nephropathy from T-Cell Mediated Rejection
B. Adam,¹ S. Wagner,¹ J. Bräsen,² V. Bröcker,² V. D'Agati,³ C. Drachenberg,⁴ E. Farkash,⁵ A. Farris,⁶ L. Geldenhuys,⁷ A. Magil,⁸ V. Nickeleit,⁹ P. Randhawa,¹⁰ H. Regele,¹¹ M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Hannover Medical School, Hannover, Germany; ³Columbia University, New York; ⁴University of Maryland, College Park; ⁵University of Michigan, Ann Arbor; ⁶Emory University, Atlanta; ⁷Dalhousie University, Halifax, Canada; ⁸University of British Columbia, Vancouver, Canada; ⁹University of North Carolina, Chapel Hill; ¹⁰University of Pittsburgh, Pittsburgh; ¹¹Medical University of Vienna, Vienna, Austria.
Background: Improved immunosuppression protocols have reduced the incidence of T-cell mediated rejection (TCMR) but still carry a significant risk of BK polyomavirus nephropathy (BKVN). Despite…