Articles tagged "Kidney transplantation"

2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in a Non-Human Primate Identifies Inflammation as a Risk Factor in Chronic Antibody Mediated Rejection
R. Smith,¹ B. Adam,² A. Rosales,¹ M. Matsunami,³ T. Oura,³ B. Cosimi,³ T. Kawai,³ M. Mengel,² R. Colviin.¹
¹Pathology, Massachusetts General Hospital, Boston, MA; ²Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ³Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionChronic alloantibody mediated rejection (CAMR) is a major risk factor in renal allografts. Some inflammation is commonly identified within CAMR, though mostly low grade, and…
2018 American Transplant Congress
Long-Term Kidney Transplant Survival after Deceased-Donor Acute Kidney Injury
I. Hall, E. Akalin, J. Bromberg, M. Doshi, M. Harhay, Y. Jia, S. Mansour, S. Mohan, T. Muthumkumar, P. Reese, B. Schröppel, P. Singh, H. Thiessen-Philbrook, F. Weng, C. Parikh.
Deceased Donor Study Consortium, New Haven, CT.
Purpose: Acute kidney injury (AKI) occurs frequently in deceased donors and is associated with organ discard. Prior studies indicate an association between donor AKI and…
2018 American Transplant Congress
Robotic Kidney Transplantation in Obese Recipients: The New Standard?
I. Tzvetanov, C. Di Bella, K. Tulla, M. Spaggiari, F. Gheza, P. Di Cocco, J. Oberholzer, E. Benedetti.
Surgery, University of Illinois, Chicago, IL; Surgery, University of Virginia, Virginia, VA.
Introduction: Obese recipients could potentially benefit from the introduction of minimally invasive techniques for kidney transplantation. We have introduced robotic kidney transplantation for our obese…
2018 American Transplant Congress
A Transcriptomic Signature in PBMC from Kidney Transplant Recipients at Baseline Predicts Early Acute Rejection
W. Zhang,¹ Z. Yi,¹ P. Cravedi,¹ L. Li,¹ K. Keung,² C. Wei,¹ M. Menon,¹ J. Dudley,¹ P. O'Connell,² B. Murphy.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; ²Medicine, The University of Sydney, Sydney, Australia.
Background: Our multi-center study (Genomics of Chronic Allograft Rejection, GoCAR) revealed that early acute rejection (EAR, developed before 6 months post-transplant) is associated with later…
2018 American Transplant Congress
Proton-Pump Inhibitor Utilization is Associated with Higher Rates of Clostridium difficile Infection and Hypomagnesemia after Kidney Transplant
G. Kipp,² K. Dancsecs,¹ A. Lapping.¹
¹School of Pharmacy, Duquesne University, Pittsburgh, PA; ²Abdominal Transplant, Allegheny General Hospital, Pittsburgh, PA.
The purpose of this project was to identify how many kidney transplant patients were taking a proton pump inhibitor (PPI) after kidney transplant at our…
2018 American Transplant Congress
Intragraft Gene Expression Differentiates Polyomavirus Nephropathy from T-Cell Mediated Rejection
B. Adam,¹ S. Wagner,¹ J. Bräsen,² V. Bröcker,² V. D'Agati,³ C. Drachenberg,⁴ E. Farkash,⁵ A. Farris,⁶ L. Geldenhuys,⁷ A. Magil,⁸ V. Nickeleit,⁹ P. Randhawa,¹⁰ H. Regele,¹¹ M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Hannover Medical School, Hannover, Germany; ³Columbia University, New York; ⁴University of Maryland, College Park; ⁵University of Michigan, Ann Arbor; ⁶Emory University, Atlanta; ⁷Dalhousie University, Halifax, Canada; ⁸University of British Columbia, Vancouver, Canada; ⁹University of North Carolina, Chapel Hill; ¹⁰University of Pittsburgh, Pittsburgh; ¹¹Medical University of Vienna, Vienna, Austria.
Background: Improved immunosuppression protocols have reduced the incidence of T-cell mediated rejection (TCMR) but still carry a significant risk of BK polyomavirus nephropathy (BKVN). Despite…
2018 American Transplant Congress
Expression of the Senescence Marker P16/INK4A in Kidney Implantation Biopsies is Uniquely Associated with Poor Late Graft Function
K. Famulski, P. Halloran.
University of Alberta, Edmonton, Canada.
With the aging donor population, accurate assessment of tissue quality of deceased donor kidneys is required to determine the intermediate and long term graft performance,…
2018 American Transplant Congress
Medication Reconciliation in Abdominal Transplantation
S. Todd,¹ J. Perryman,² R. Subramanian,² A. Patel,² M. Hawthorne,² R. Buenvenida,² K. Lee,² W. Allison,² D. Lo,² P. Reshamwala.²
¹Department of Pharmacy, Emory University Hospital, Atlanta, GA; ²Emory Transplant Center, Emory University Hospital, Atlanta, GA.
Medication adherence post transplantation is vital. Upon discharge, abdominal transplant patients receive a medication list from the electronic medical record (EMR) and obtain a medication…
2018 American Transplant Congress
Urine AngiotensinII Signature Proteins as Biomarkers of Fibrosis in Kidney Transplant Recipients
Z. Mohammed-Ali,¹ S. Reid,^1,3 T. Tokar,¹ A. Tavares,² P. Yip,¹ H. Cardinal,² Y. Li,¹ S. Kim,^1,3 I. Jurisica,^1,3 R. John,¹ A. Konvalinka.^1,3
¹University Health Network, Toronto, ON, Canada; ²Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada; ³University of Toronto, Toronto, ON, Canada.
AngiotensinII (AngII), the main effector of the renin-angiotensin system (RAS), causes kidney interstitial fibrosis/tubular atrophy (IFTA). However, there are presently no markers of AngII renal…
2018 American Transplant Congress
Molecular Classifiers Can Outperform the Flawed Histologic “Gold Standard” on Which They Are Trained
J. Reeve, P. Halloran.
University of Alberta, Edmonton, Canada.
The histologic diagnosis of rejection in organ transplants is known to be an imperfect gold standard. Therefore, it might be assumed that molecular classifiers built…