Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Vesicoureteral Reflux after Kidney Transplantation Influences Long-Term Graft Survival
T. Hirose,¹ K. Hotta,² N. Fukuzawa,³ A. Mitsuke,³ H. Harada.³
¹Urology, Sapporo City General Hospital, Sapporo, Japan; ²Renal and Genito-Urinary Surgery, Hokkaido University, Sapporo, Japan; ³Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan.
[Introduction] Post-transplant vesicoureteral reflux (VUR) is a complication of kidney transplantation (KT) causing graft interstitial fibrosis and tubular atrophy. However, risk factors for VUR or…
2018 American Transplant Congress
Donor Reactive Eomesdermin^hiCD8⁺ T Cells Are Significantly Upregulated Early after Transplant in Kidney Transplant Patients without Rejection
A. Perez-Gutierrez,^1,2 D. Metes,¹ S. Hariharan,¹ A. Thomson,¹ M. Ezzelarab.¹
¹Surgery, Thomas Starzl Transplantation Institute, Pittsburgh, PA; ²Surgery, Transplantation Institute, University of Chicago, Chicago, IL.
IntroductionMemory T cell responses play a critical role in the outcome of allo-transplantation. While the role of the T-box transcription factor Eomesodermin (Eomes) in the…
2018 American Transplant Congress
Cell Free DNA Sequencing for Diagnosing Infections, Estimating Growth Rates, and Characterizing Antibiotic Resistomes in Urine Supernatants
J. Lee,¹ P. Burnham,² D. Dadhania,¹ M. Heyang,² F. Chen,² M. Suthanthiran,¹ I. De Vlaminck.²
¹Weill Cornell Medicine, New York, NY; ²Cornell University, Ithaca, NY.
INTRODUCTION. We examined the utility of cell-free DNA (cfDNA) sequencing of urine supernatants in kidney transplant recipients for diagnosing rare and common urinary tract infections…
2018 American Transplant Congress
Medullary Tissue Sampling in Renal Allograft Biopsy is More Sensitive for Pathologic Diagnosis of PVN
D. Abdelwahab,¹ H. Khamash,¹ S. Kriegshauser,³ R. Heilman,¹ M. Smith.²
¹Nephrology and Transplant, Mayo Clinic, Phoenix; ²Pathology and Laboratory Medicine, Mayo Clinic, Phoenix; ³Radiology, Mayo Clinic, Phoenix.
Background Post-transplant polyoma virus nephropathy (PVN) prevalence is 1-10%. Definitive PVN diagnosis requires polyoma virus presence in infected cells, done with immunohistochemical staining for SV40…
2018 American Transplant Congress
Waitlist Survival is Approaching Survival after Kidney Transplantation
A. Rana, B. Murthy, C. O'Mahony, J. Goss.
Abdominal Tranplantation, Baylor College of Medicine, Houston, TX.
Backround: Kidney transplantation confers a significant survival benefit to its recipients. Our objective was to reassess this survival benefit in light of improving outcomes on…
2018 American Transplant Congress
Impact of Ambulatory Transplant Pharmacy Services on Outcomes and Readmissions in Adult Abdominal Transplant Recipients
K. Joyal,¹ C. Rogers,² M. Cote,² M. Pavlakis,² A. Evenson,² V. Patwardhan,² K. Richards.²
¹Northeastern University, Boston, MA; ²Beth Israel Deaconess Medical Center, Boston, MA.
Over the past two decades, the role of transplant pharmacists (Txp Rx) has expanded following revised guidance from UNOS and CMS. There is little data…
2018 American Transplant Congress
Intragraft MicroRNAs Foretell Fibrosis in Kidney Transplant Recipients
H. Yang,¹ L. Amrouche,² K. Akat,³ C. Li,¹ Z. Khan,¹ C. Tinel,² T. Tuschl,³ D. Anglicheau,² T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Hôpital Necker, Paris, France; ³Rockefeller University, New York.
BackgroundIdentifying biomarkers that anticipate tubulointerstitial fibrosis (IFTA) of the kidney allograft will be a transformative advance.Aim/HypothesisIntragraft microRNA profile of 3-month surveillance biopsies reported as normal…
2018 American Transplant Congress
Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol
K. Jensen,¹ P. Zheng,² J. Xuhuai,² A. Saraswathula,¹ J. Scandling,³ S. Busque,⁴ J. Shizuru,⁵ R. Lowsky,⁵ A. Shori,⁴ H. Maecker,² E. Engleman,¹ E. Meyer,⁵ S. Strober.¹
¹Immunology, Stanford School of Medicine, Stanford, CA; ²Human Immune Monitoring Center, Stanford School of Medicine, Stanford, CA; ³Nephrology, Stanford School of Medicine, Stanford, CA; ⁴Surgery, Stanford School of Medicine, Stanford, CA; ⁵Blood & Marrow Transplantation, Stanford School of Medicine, Stanford, CA.
Tolerance induction after combined organ and hematopoietic cell transplantation can be achieved using conditioning with total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG), in both…
2018 American Transplant Congress
NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence
M. Terada,¹ J. Duong Van Huyen,² F. Drieux,⁴ C. Legendre,³ P. Bruneval,¹ M. Rabant.²
¹Pathology Department, Georges Pompidou European Hospital, Paris, France; ²Pathology Department, Necker-Enfants Malades Hospital, Paris, France; ³Kidney Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; ⁴Pathology Department, Centre Henri Becquerel, Rouen, France.
Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…
2018 American Transplant Congress
Do Protocol Biopsies in the Highly Sensitized Improve Renal Allograft Survival? A Single Center Evaluation of 2 Year Graft Function
S. Kuppachi, R. Kalil, M. Fraer, M. Sanders, M. Swee, Z. Stewart, C. Thomas.
Organ Transplant Center, University of Iowa, Iowa City, IA.
Highly sensitized kidney transplant recipients (hsKTR) are at an increased risk of antibody mediated rejection (AMR). Following implementation of the new kidney allocation system (KAS)…