Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Thrombotic Microangiopathy after Renal Transplantation: A Clinicopathological Study and Identification of Prognostic Factors
K. Dessaix,¹ C. Bontoux,² O. Aubert,¹ J. Zuber,¹ R. Sberro Soussan,¹ V. Frémeaux-Bacchi,³ M. Le Quintrec,⁴ C. Legendre,¹ M. Rabant.²
¹Renal Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; ²Pathology Department, Necker-Enfants Malades Hospital, Paris, France; ³Immunology Laboratory, Georges Pompidou European Hospital, Paris, France; ⁴Nephrology Department, CHU Montpellier, Montpellier, France.
IntroductionThrombotic microangiopathy (TMA), whether de novo or recurrent, is a serious complication after renal transplantation, but prognostic factors and the role of complement inhibitors in…
2018 American Transplant Congress
Kidney Transplantation and Progression of Peripheral Arterial Disease in the Ipsilateral Lower Extremity
A. Rasmussen,¹ R. Moore,¹ T. Schuler,¹ G. Todd,¹ K. Wen.²
¹Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada; ²Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Objectives:We aimed to investigate whether receiving a kidney transplant allograft graft increases the risk of ipsilateral lower limb amputation in patients with pre-existing peripheral arterial…
2018 American Transplant Congress
Trends and Policy Influences on Multiple Listing Practices for Kidney Transplantation between 2000 and 2017
M. Decoteau,¹ D. Stewart,² A. Toll,² J. Case,¹ C. Marsh.¹
¹Organ Transplantation, Scripps Green Hospital, La Jolla, CA; ²United Network for Organ Sharing, Richmond, VA.
BACKGROUND: Organ allocation policies continually evolve to address long transplant wait times and a limited donor organ pool. Transplant candidates may list at multiple centers…
2018 American Transplant Congress
Prevalence and Impact of CYP3A5 Genomic Variances on Clinical Outcomes among African-American Kidney Transplant Recipients
A. Maldonado,¹ S. Hudson,² L. Rebellato,² T. Asempa.¹
¹Vidant Medical Center, Greenville, NC; ²East Carolina University, Greenville, NC.
Introduction: Kidney transplantation in African American (AA) recipients continues to demonstrate inferior outcomes when compared with other race/ethnicities. Contributing factors encompass differences in pharmacogenomics, and…
2018 American Transplant Congress
Validating Molecular Microscope Readings and Estimating Agreement with Histology
P. Halloran, J. Reeve, The INTERCOMEX Study Group.
ATAGC, Edmonton, Canada.
We previously described a microarray diagnostic system (MMDx) for rejection in 1208 kidney transplant biopsies (J. Reeve et al. JCI Insight 2 (12), 2017). The…
2018 American Transplant Congress
A Low Level of De Novo DSA Sialylation is Associated with a Decreased of Allograft Survival in Non-Sensitized Kidney Transplant Recipients
M. Bonnet,^1,2 V. Pernin,^1,3 J-.E. Serre,¹ V. Georgescu,⁴ M. Le Quintrec,^1,2,3 G. Mourad,^1,2 J-.F. Eliaou,^2,5 C. Rene.^2,5
¹Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, Montpellier University Hospital, Montpellier, France; ²University of Medicine, Montpellier University, Montpellier, France; ³Inserm U1183, IRMB, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France; ⁴Department of Medical Information, Montpellier University Hospital, Montpellier, France; ⁵Department of Immunology, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France.
Background. In kidney transplantation, de novo donor specific antibodies (dnDSA) are associated with antibody-mediated rejection (ABMR) and graft failure. While appearance of dnDSA, there is…
2018 American Transplant Congress
Cost Impacts of Alternative Kidney Transplant Immunosuppression: A National Cohort Study
K. Lentine,¹ D. Axelrod,² V. Dharnidharka,³ H. Xiao,¹ D. Brennan,⁴ D. Segev,⁴ H. Randall,¹ R. Ouseph,¹ A. Naik,⁵ N. Lam,⁶ T. Alhamad,³ B. Kasiske,⁷ G. Hess,⁸ M. Schnitzler.¹
¹Saint Louis Univ, St. Louis; ²Lahey Clinic, Burlington; ³Washington Univ, St. Louis; ⁴Johns Hopkins, Baltimore; ⁵Univ Michigan, Ann Arbor; ⁶Univ Alberta, Edmonton, Canada; ⁷Hennepin County, Minneapolis; ⁸Symphony Health, Conshohocken.
Economic outcomes are increasingly considered along with clinical efficacy to guide choice of alternative therapies. We examined the cost impact of kidney transplant (KTx) induction…
2018 American Transplant Congress
Longitudinal Molecular Assessment of Renal Allograft and Short-Term Outcome: Markers of Injury and Recovery
S. Bontha,¹ A. Fernandez,¹ E. Bardhi,¹ L. Gallon,² V. Mas,¹ D. Maluf.¹
¹Surgery, UVA, Charlottesville; ²NWU, Chicago.
Background: Ischemia reperfusion (I/R) is influenced by both donor and recipient characteristics and affects early graft function and the recovery process. To understand underlying mechanisms…
2018 American Transplant Congress
DNA Methylation Age and Differential Patterns of DNA Methylation in Older Compared with Younger Kidney Transplant Recipients
J. Schaenman, X. Zhou, R. Guo, M. Rossetti, E. Liang, B. Abdalla, E. Lum, S. Bunnapradist, G. Danovitch, E. Reed, D. Elashoff.
David Geffen School of Medicine at UCLA, Los Angeles, CA.
Introduction: Older transplant recipients experience increased rates of infection and death, but decreased rates of rejection, suggesting a role of immune dysfunction. Analysis of DNA…
2018 American Transplant Congress
Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant
A. Brubaker,¹ D. Stoltz,¹ M. Grskovic,² R. Woodward,² A. Gallo.¹
¹Department of Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; ²CareDx, Brisbane, CA.
Background: Recently, high immunologic risk patients comprise a significant percentage of the total adult renal transplants performed yearly. Surveillance management of these patients and interpretation…