Articles tagged "Kidney transplantation"

2018 American Transplant Congress
mTOR Inhibitor Based Immunosuppression Regimens Are Not Associated with Lower Risk for BK Infection
R. Daloul,¹ R. Pelletier,² A. Rajab,² G. Bumgardner,² M. Alebrahim,² C. Akateh,³ K. Washburn,² A. El-Hinnawi.²
¹Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH; ²Transplant Surgery, The Ohio State University Wexner Medical Center, Columbus, OH; ³Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Introduction: BK virus continues to be a significant post-transplant complication with increasing incidence in the current era of potent immunosuppression. Mammalian target of rapamycin inhibitors…
2018 American Transplant Congress
Development of a Classification of Immunosuppressant Medication Nonadherence Tool to Enable the Objective Measurement of Immunosuppressant Medication Nonadherence in Kidney Transplant Patients
D. Goodall, M. Willicombe, A. McLean, D. Taube.
Imperial College Renal and Transplant Centre, London.
IntroductionKDIGO define nonadherence to immunosuppression as a 'deviation from the prescribed medication regimen sufficient to adversely influence the regimen's intended effect'. There is however, no…
2018 American Transplant Congress
Ex Vivo Bloodless Oxygen Carrier for Perfusion of DCD Kidneys during Subnormothermic Storage
P. Luke,^1,2 M. Richard-Mohamed,² A. Haig,³ R. Mayer,² S. Aquil,² A. Sener,² A. Jevnikar,^1,2 R. Bhattacharjee.^1,2
¹Matthew Mailing Centre for Translational Transplant Studies, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada.
Background: Non-oxygenated static or machine perfusion in cold (4[deg]C) remains the gold standard in transplantation and an optimal method of oxygen delivery to ischemic kidneys…
2018 American Transplant Congress
Urine Podocin mRNA to Nephrin mRNA Ratio as a Marker of "Podocyte Stress" among Kidney Allografts Losing Function
A. Naik,¹ J. Aqeel,¹ D. Cibrik,² M. Samaniego,¹ S. Wang,¹ M. Chowdhury,¹ F. Afshinnia,¹ R. Wiggins.¹
¹Univ of Michigan, Ann Arbor; ²Univ of Kansas, Kansas City.
Increasing data supports the hypothesis that long term allograft loss-of-function is associated with progressive glomerulosclerosis (GS). In models of progressive GS the ratio of two…
2018 American Transplant Congress
Assessing Fibrosis Burden in Renal Allograft with Chronic Damage Using Functional Magnetic Resonance Imaging
J. Wen,¹ W. Wang,² X. Ni,¹ Y. Yu,³ J. Chen,¹ L. Zhang,³ Z. Liu.¹
¹Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, Jiangsu, China; ²Nanjing Medical University, Jinling Clinical Hospital, Nanjing, Jiangsu, China; ³Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.
Background: Renal allograft fibrosis burden is a strong prognosticator for chronic damage and can only be accurately measured through transplant biopsy at present. We hypothesized…
2018 American Transplant Congress
Impact of Immediate Graft Function in Kidney Transplant Outcomes
C. Arias-Cabrales, M-.J. Pérez-Sáez, D. Redondo-Pachón, M. Crespo, M. Mir, J. Pascual.
Nephrology, Hospital del Mar, Barcelona, Spain.
Introduction Delayed graft function (DGF), defined as dialysis needed the first week after transplantation are related with poor graft outcomes. There are few information about…
2018 American Transplant Congress
Pre-Existing Allograft Diabetic Nephropathy from Diabetic Donor is Reversible after Kidney Transplantation in Non-Diabetic Recipient
K. Hotta,¹ D. Iwami,¹ H. Harada,² Y. Fukasawa,² H. Okada,¹ H. Higuchi,¹ T. Hirose,² N. Fukuzawa,² N. Shinohara.¹
¹Hokkaido University Hospital, Sapporo, Japan; ²Sapporo City General Hospital, Sapporo, Japan.
【Introduction】The shortage of kidney donor has limited the treatment of patients with end-stage kidney disease. To use diabetic donor with normal renal function is would…
2018 American Transplant Congress
CMV Viremia and Development of CMV-Specific Cytotoxic T-Cells (CMV-Tc) in Pediatric Renal Transplant Recipients
H. Pizzo, B. Shin, M. Toyoda, S. Jordan, D. Puliyanda.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: The use of lymphocyte depleting agents (LDA) for induction immunosuppression among renal transplant (tx) recipients raises concern for the increased susceptibility to viral infections,…
2018 American Transplant Congress
Delayed Achievement of Therapeutic Tacrolimus Levels after Renal Transplantation is Not Associated with Increased Incidence of Early Acute Rejection: Single-Center Results
R. Marshall, J. Brandenberger, A. Cantafio, J. Halldorson, R. Bakthavatsalam, A. Dick, S. Rayhill, J. Reyes, J. Perkins.
Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA.
Induction therapy followed by maintenance with a calcineurin inhibitor aims to minimize the incidence of early rejection and optimize the potential for allograft function. However…
2018 American Transplant Congress
mRNA Transcript Profiling of 3 Genes in Renal Allograft Biopsies (Bx) Improves Accuracy of Antibody-Mediated Rejection (ABMR) Diagnosis in Transplant Recipients Desensitized with IVIG+Rituximab+Immunoglobulin G-Degrading Enzyme of Streptococcus Pyogenes (IdeS)
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Multiple molecular signatures specific to ABMR based on gene expression in renal allograft Bx of transplant recipients were reported. Here we assessed mRNA transcript…