Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Donor-Specific Antibody Mediates Chronic, but Not Acute, Kidney Allograft Rejection in the Absence of Natural Killer Cells
T. Yagisawa, N. Dvorina, A. Valujskikh, W. Baldwin 3rd, R. Fairchild.
Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
The incidence of antibody-mediated kidney graft rejection continues to increase. We previously reported that dysregulated donor-specific antibody (DSA) responses were induced in B6.CCR5-/- mice transplanted…
2018 American Transplant Congress
Frailty is Predictive of Early Post-Transplant Infection in Older Renal Transplant Recipients
M. Malinis,¹ C. Ogbejesi,² J. Luo,³ Y. Zhang,³ W. Asch,⁴ R. Deshpande,⁵ S. Akhtar.⁵
¹Section of Infectious Diseases, Yale School of Medicine, New Haven, CT; ²College of Medicine, Central Michigan University, Mount Pleasant, MI; ³Section of Surgical Outcomes and Epidemiology, Department of Surgery, Yale School of Medicine, New Haven, CT; ⁴Section of Nephrology, Yale School of Medicine, New Haven, CT; ⁵Department of Anesthesiology, Yale School of Medicine, New Haven, CT.
Background: Frailty is predictive of postoperative morbidity, including infections in older surgical patients. It is not known if frailty is associated with post-operative infections in…
2018 American Transplant Congress
Diagnostic Value and Confounding Factors of Urinary Biomarkers in the Non-Invasive Screening of Renal Allograft Inflammation
A. Vermorel,¹ A. Devresse,¹ C. Tinel,^1,2 V. Sauvaget,² L. Morin,² L. Amrouche,^1,2 M. Rabant,^2,3 D. Anglicheau.^1,2
¹Renal Transplantation Unit, Necker-Enfants Malades Hospital, Paris, France; ²INSERM U1173, Institut Necker Enfants Malades, Paris, France; ³Pathology, Necker-Enfants Malades Hospital, Paris, France.
IntroductionThe value of urinary biomarkers has already been demonstrated in diagnosing acute rejection of the renal allograft, but confounding factors, which may interfere with their…
2018 American Transplant Congress
Efficacy and Safety of Bleselumab in Kidney Transplant Recipients: A Phase 2, Randomized, Open-Label Study
R. Harland,¹ G. Klintmalm,² S. Jensik,³ H. Yang,⁴ J. Bromberg,⁵ J. Holman,⁶ M. Anil Kumar,⁶ V. Santos,⁶ T. Larson,⁶ X. Wang.⁶
¹University of Arizona, Tucson; ²Annette C. and Harold C. Simmons Transplant Institute, Dallas; ³Rush University, Chicago; ⁴PinnacleHealth Transplant Associates, Harrisburg; ⁵University of Maryland, Baltimore; ⁶Astellas Pharma Global Development, Inc., Northbrook.
Introduction: Bleselumab (ASKP1240) is an anti-CD40 monoclonal antibody currently in development. This phase 2, randomized, open-label study assessed the efficacy and safety of bleselumab in…
2018 American Transplant Congress
Relationship between Mixed Chimerism and Acceptance of HLA-Matched and Mismatched Kidney Transplants after Withdrawal of Immunosuppressive Drugs
J. Scandling, S. Busque, R. Lowsky, J. Shizuru, K. Jensen, A. Shori, E. Engleman, E. Meyer, R. Hoppe, S. Strober.
Stanford University, Stanford, CA.
Classical studies in cattle and rodents showed that mixed chimerism (MXC) established in fetuses and neonates was permanent, linked to immune tolerance and graft acceptance…
2018 American Transplant Congress
In-Situ Tissue-Based Gene Expression Profiling is a Reliable Method to Detect Gene Transcripts in Human Kidney Transplant Biopsies
D. Dobi,¹ J. Henrik,² T. Sigdel,² A. Chen,¹ Z. Laszik.¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, University of California, San Francisco, San Francisco, CA.
Purpose. Validation studies that would enable the clinical application of quantitative in situ tissue-based gene expression profiling in renal transplantation are lacking. In this study,…
2018 American Transplant Congress
False-Positive Flow-Cytometric T Cell Crossmatch Associated with Blood Type Antigen Expressed on Lymphocytes in ABO Incompatible Kidney Transplantation
D. Iwami,¹ M. Ito,² K. Hotta,¹ H. Higuchi,¹ N. Shinohara.¹
¹Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan; ²Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
Background: Flow-cytometric T cell crossmatch (FTXM) uses live donor lymphocytes to detect anti-donor-human leukocyte antigen (HLA) IgG antibodies. Therefore, the results can be affected by…
2018 American Transplant Congress
Early Experience Using Donor-Derived Cell-Free DNA for Detection of Rejection in Kidney Transplantation
E. Huang, A. Vo, J. Choi, A. Peng, S. Sethi, R. Najjar, S. Jordan.
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction:Donor-derived cell free DNA (ddDNA; Allosure, CareDX) has been validated as a non-invasive test that can discriminate rejection from non-rejection in kidney transplantation, but has…
2018 American Transplant Congress
Immunologic Impact of Tocilizumab Treatment in Kidney Transplant Recipients with Allograft Inflammation
J. Leung, S. Chandran, F. Vincenti, Q. Tang.
UCSF, San Francisco.
Background: Proinflammatory cytokine IL-6 increases effector/memory T-cells, induces Th17 cells and prevents the induction of Tregs. IL-6 expression in kidney biopsies is elevated during acute…
2018 American Transplant Congress
Interactive Software for Simulation and Management of a Kidney Paired Donation Program
M. Bray,¹ W. Wang,¹ M. Rees,² P. Song,¹ A. Leichtman,³ V. Ashby,¹ J. Kalbfleisch.¹
¹University of Michigan, Ann Arbor, MI; ²Alliance for Paired Donation, Maumee, OH; ³Arbor Research, Ann Arbor, MI.
In kidney paired donation (KPD), candidates with willing but incompatible donors are pooled together with the goal of finding new transplant opportunities by exchanging donors.…