Articles tagged "Kidney transplantation"

2018 American Transplant Congress
p16^INK4a Deletion in Vascular Endothelium Improves Kidney Regeneration Post Ischemia Reperfusion Injury
A. Melk,¹ A. Baisantry,^1,2 S. Wang,¹ F. Kubaink,¹ R. Bhayadia,¹ R. Schmitt.²
¹Department of Kidney, Liver & Metabolic Diseases, MHH, Hannover, Germany; ²Department of Nephrology, MHH, Hannover, Germany.
Background: Ischemia Reperfusion injury (IRI) mediated cellular senescence in kidney allografts has been linked to a loss in regenerative potential and delayed graft function. Injured…
2018 American Transplant Congress
Pilot Study of Plasma Cell Niche-Targeted Therapy for Enhancement of Proteasome Inhibitor Effectiveness
S. Tremblay,¹ C. Castro-Rojas,² J. Driscoll,¹ S. Knechtle,³ A. Shields,¹ R. Alloway,¹ H. Singh,² D. Hildeman,² E. Woodle.¹
¹UCincinnati, Cincinnati; ²Cincinnati Children's, Cincinnati; ³Duke, Durham.
HLA antibody (Ab)-secreting bone marrow (BM) plasma cell (PC) survival depends on niche occupancy via a CXCR4 (PC)-CXCL12 (BM stromal cell) interaction. Plerixafor inhibits CXCR4-CXCL12…
2018 American Transplant Congress
The Stunning Rise in Organ Donors Deceased from Drug Overdose
N. Agrawal,¹ S. Rhazouani,¹ D. Reino,¹ D. McMichael,² C. McClenney,³ D. Sears,¹ K. Al Khalloufi,¹ S. Gebreselassie,¹ S. Ebaid,¹ M. Berho,⁴ X. Zervos,¹ C. Sheffield,¹ A. Tzakis.¹
¹Transplantation, Cleveland Clinic Florida, Weston, FL; ²Research, Cleveland Clinic, Cleveland, OH; ³Life Alliance Organ Recovery Agency, University of Miami, Miami, FL; ⁴Department of Pathology, Cleveland Clinic Florida, Weston, FL.
In the recent years we noticed an increase in the number of local deceased organ donors who had died of drug overdose. This coincides with…
2018 American Transplant Congress
Multi-Organ (M-O) Prioritization of Kidneys: ? Time for Policy Modification
M. Aeder, N. Turgeon.
Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH; Surgery, Emory University, Atlanta, GA.
The revised Kidney Allocation System (KAS) has been operational for 3 years. The bolus effects seen early following the introduction have abated and a steady…
2018 American Transplant Congress
Early Considerations for Deceased Donor Chains
A. Toll,¹ R. Leishman,¹ V. Casingal,² M. Aeder,³ T. Sandholm,⁴ N. Turgeon.⁵
¹UNOS, Richmond, VA; ²Carolinas HeathCare Sys, Charlotte, NC; ³Univ Hosp Med Ctr, Cleveland, OH; ⁴Carnegie Mellon Univ, Pittsburgh, PA; ⁵Emory Univ, Atlanta, GA.
Background: The potential use of deceased kidney donors (DDs) to initiate kidney paired donation (KPD) chains (DD chains) has been of interest to the transplant…
2018 American Transplant Congress
A Novel Peripheral Blood mRNA Biomarker Predicts Subclinical Rejection and Kidney Transplant Outcomes
J. Friedewald,¹ S. Kurian,² T. Whisenant,² R. Heilman,³ E. Poggio,⁴ C. Marsh,² P. Baliga,⁵ N. Bridges,⁶ J. Odim,⁶ M. Brown,⁶ D. Ikle,⁷ B. Armstrong,⁷ J. Charette,¹ S. Brietigam,¹ N. Sustento-Reodica,¹ L. Zhao,¹ M. Kandpal,¹ D. Salomon,² M. Abecassis.¹
¹Northwestern Medicine, Chicago; ²Scripps, La Jolla; ³Mayo AZ, Scottsdale; ⁴Cleveland Clinic, Cleveland; ⁵MUSC, Charleston; ⁶NIAID, Bethesda; ⁷Rho, Chapel Hill.
BACKGROUNDSub-clinical acute rejection (subAR) in kidney transplant recipients (KTR), defined as histological rejection on surveillance biopsy (Bx) in a patient with stable renal function, signals…
2018 American Transplant Congress
Dialysis Modality, Inflammation, and Frailty in Kidney Transplant Candidates
P. Shrestha, H. Ying, M. McAdams DeMarco, D. Segev.
JHU, Baltimore, MD.
Inflammation is associated with poor physical performance, frailty, disability and death in community-dwelling older adults. Given the elevated inflammation levels among ESRD patients, it is…
2018 American Transplant Congress
Everolimus with Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplant Recipients: Efficacy and Safety Outcomes from the TRANSFORM Study
S. Mulgaonkar,¹ J. Pascual,¹ S. Chadban,¹ H. Tedesco,¹ S. Berger,¹ Y. Qazi,¹ C. Legendre,¹ N. Basic-Jukic,¹ P. Bernhardt,² F. Vincenti.¹
¹TRANSFORM Study Group, Livingston; ²Novartis Pharma AG, Basel, Switzerland.
Purpose: Everolimus (EVR)-facilitated calcineurin inhibitor (CNI) reduction regimens help prevent long-term CNI nephrotoxicity in kidney transplant recipients (KTxRs). TRANSFORM (NCT01950819) is the largest study in…
2018 American Transplant Congress
Validation Study of Operational Tolerance Signatures in Korean Kidney Transplantation Recipients
J. Seo,¹ Y. Lee,¹ Y. Kim,¹ J. Moon,¹ K-.H. Jeong,¹ C-.D. Kim,² J. Park,³ B. Jeong,⁴ S-.H. Lee.¹
¹Department of Nephrology, School of Medicine, Kyung Hee University, Seoul, Korea; ²Department of Nephrology, Kyung-pook National University School of Medicine, Daegu, Korea; ³Department of Nephrology, Sungkyunkwan University, Samsung Hospital, College of Medicine, Seoul, Korea; ⁴Department of Nephrology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Background:A peripheral B cell population was significantly higher in drug-free operationally tolerant patients than those with stable graft function or acute rejection under standard immunosuppression.…
2018 American Transplant Congress
Donor-Derived Cell-Free DNA Outperforms Serum Creatinine Changes for Identifying Kidney Transplant Rejection
M. Weir,¹ D. Hiller,² J. Yee,² A. Matas.³
¹University of Maryland School of Medicine, Baltimore, MD; ²CareDx, Brisbane, CA; ³University of Minnesota School of Medicine, Minneapolis, MN.
Purpose: In the DART study, donor-derived cell-free DNA (dd-cfDNA) discriminated biopsy-based diagnosis of active rejection in kidney transplant patients but serum creatinine (sCr) level did…