2018 American Transplant Congress
Development and Validation of a Socioeconomic Kidney Transplant Derailers Index (KTDI)
Transplant evaluation requires an assessment of socioeconomic challenges patients face that may derail them from obtaining a kidney transplant (KT). We developed and validated a…2018 American Transplant Congress
QPI-1002, a siRNA Targeting p53: Improvement in Outcomes Following Acute Kidney Injury (AKI): Cardiac Surgery to AKI Donors
Background: QPI-1002 has been observed to statistically reduce the incidence, severity and duration of AKI in a large Phase 2 study of AKI following cardiac…2018 American Transplant Congress
Association of Health Literacy with Adverse Outcomes among Kidney Transplant Candidates and Recipients
Johns Hopkins University, Baltimore, MD.
Limited health literacy (LHL) is known to adversely affect health outcomes in patients managing chronic illness. We aimed to examine the association between LHL, listing,…2018 American Transplant Congress
Individualized Immunosuppression through Risk-Stratification in Renal Transplantation Preserves Excellent Outcomes at Three Years
University of Virginia Health System, Charlottesville, VA.
Risk-stratification of renal transplant recipients based on immunologic risk factors allows for tailored immunosuppression (IS), but long term follow up is limited. This study evaluates…2018 American Transplant Congress
Targeted Donor Complement Blockade after Brain-Death Prevents Delayed Graft Function but Not Progression to Antibody-Mediated Rejection in a Non-Human Primate Model of Kidney Allo-Transplantation
1Surgery, University of Wisconsin-Madison, Madison, WI; 2Pharming Group N.V, Leiden, Netherlands.
Introduction: Donor brain death (BD) triggers a complement-mediated inflammatory response linked to renal injury which has been associated to delayed graft function (DGF) and the…2018 American Transplant Congress
Impact of the New KAS on Transplant Rates in Highly-HLA Sensitized (HS) Patients after Desenstization (DES): 3yrs Post Implementation
Kidney Transplant, Cedars-Sinai Medical Center, LA, CA.
Introduction: The KAS aims to increase equity in organ allocation for broadly sensitized (HS) patients, especially (CPRA 99-100%). Coupling desensitization (DES) + KAS likely will…2018 American Transplant Congress
Economic Evaluation of Contemporary Kidney Transplant Practice
Kidney transplantation (KTx) has been established as the optimal therapy for medically suitable patients with end-stage renal disease, prolonging survival and reducing health care spending.…2018 American Transplant Congress
No Kidney Left Behind: Are We Maximizing Utilization of Deceased Donors with AKI?
Renal Transplantation, Columbia University, New York City, NY.
Introduction: Kidneys from donors with elevated terminal creatinine (Cr) and acute kidney injury (AKI) can be transplanted safely, yet many of these organs are not…2018 American Transplant Congress
Early Graft Losses in National PKE Programs: Gone, but Lost Forever?
Background: PKE increases transplants for patients who are highly sensitized or incompatible with intended living donors. Following catastrophes like primary non-function(PNF) or early graft loss,…2018 American Transplant Congress
Urinary C5b-9 is an Independent Predictor of Graft Failure in Renal Transplant Recipients
Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands.
IntroductionChronic antibody-mediated rejection is thought to be the main cause of late kidney-allograft loss, involving donor-specific antibody–mediated activation of the complement system. Activation of filtered…
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