Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Three-Way Comparison of Central DSA, %dd-cf DNA, and Molecular Biopsy Findings in the Trifecta Study
P. F. Halloran¹, L. G. Hidalgo², Z. Demko³, A. Prewett³, J. Reeve¹, C. Lawrence⁴, D. Lowe⁴, P. Billings³, .. and the Trifecta Investigators⁵
¹Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, ²University of Wisconsin, Madison, WI, ³Natera Inc., San Carlos, CA, ⁴One Lambda Inc., West Hills, CA, ⁵., ., AB, Canada
*Purpose: Trifecta (ClinicalTrials.gov #NCT04239703) is a prospective, IRB-approved, consented study of the relationships among three central tests in kidney transplant indication biopsies: molecular biopsy diagnoses…
2022 American Transplant Congress
A New Algorithm Combining Donor Derived Cell-Free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology
P. F. Halloran¹, J. Reeve¹, K. S. Madill-Thomsen¹, N. Kaur², E. Ahmed², N. Al Haj Baddar², Z. Demko², N. Liang², R. K. Swenerton², B. G. Zimmermann², P. Van Hummelen², A. Prewett², H. Tabriziani², P. Gauthier², P. R. Billings²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Natera, Inc., Austin, TX
*Purpose: Donor derived cell-free DNA (dd-cfDNA) has been shown to be associated with allograft rejection, both histological and molecular (JASN, in press). Clinically available dd-cfDNA…
2022 American Transplant Congress
Antibody-Mediated Rejections with C1q-binding and without C1-Binding Donor-Specific Antibodies in Kidney Transplantation
J. Jeon, C. Baek
Asan Medical Center, Seoul, Korea, Republic of
*Purpose: All donor-specific antibodies (DSAs) are not clinically relevant. Therefore, the C1q assay has been recently used, but its clinical meaning and usefulness should be…
2022 American Transplant Congress
The Impact of COVID-19 on Renal Function of Kidney Transplant Recipients: A Three-Month Prospective Study
R. D. Foresto¹, H. Fagundes², V. Lafico², H. Tedesco Silva Junior², M. P. Cristelli¹, J. Pestana¹
¹Hospital do Rim, Sao Paulo, Brazil, ²Hospital do Rim, Universidade Federal de São Paulo, SAo Paulo, Brazil
*Purpose: This study aimed to assess changes in renal function during the acute disease and up to three months after the onset of symptoms among…
2022 American Transplant Congress
Clinical Significance of Delayed Graft Function and Slow Graft Function in Living Donor Kidney Transplantation
J. Song¹, S. Jeong¹, S. Min¹, J. Ha¹, J. Lee², J. Jeong³, Y. Kim¹, Y. Kim¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Boramae Medical Center, Seoul, Korea, Republic of, ³Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of
*Purpose: The delayed graft function (DGF) after kidney transplantation (KT) affects long-term graft and patient survival. We explored the time-trend of DGF and associated risk…
2022 American Transplant Congress
Analysis of Antibiotic Resistance and Risk Level of Preservation Fluid Microorganisms in Kidney Transplant Recipients
J. Li¹, X. Su¹, J. Han², Y. Huang², W. Wu¹, M. Wei², S. Yuan², C. Wu¹, J. Li¹, L. Liu¹, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China
*Purpose: As a solution for preserving kidney during procurement and transportation, preservation fluid (PF) is the main method to detect donor-derived infection. But there are…
2022 American Transplant Congress
Prebiotic Supplementation In Kidney Transplant Recipients For Preventing Infections And Gastrointestinal Upset: A Randomized Controlled Feasibility Study
S. Chan¹, C. M. Hawley¹, E. M. Pascoe², C. Z. Cao², S. B. Campbell², K. L. Campbell³, R. S. Francis², R. Hale¹, N. M. Isbel⁴, M. Morrison⁵, D. W. Johnson²
¹Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia, ²Princess Alexandra Hospital, Woolloongabba, Australia, ³Menzies Health Institute - Molecular Basis of Disease Research Program, Griffith University, Brisbane, Australia, ⁴Princess Alexandra Hospital, Brisbane, Australia, ⁵Diamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Australia
*Purpose: Modulating the large intestinal microbiome of kidney transplant recipients (KTR) may reduce infectious complications. The aim of this study was to assess the feasibility…
2022 American Transplant Congress
A Comparison of Self-Reported Physical Function to In-Person Frailty Assessments for the Prediction of Rehospitalizations After Kidney Transplantation
E. Lorenz¹, C. Kennedy¹, C. Schinstock¹, A. Kukla¹, D. Eton¹, H. Wadei², G. Mour³, P. Dean⁴, A. Rule¹, N. LeBrasseur¹, A. Cheville¹
¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Jacksonville, FL, ³Mayo Clinic, Scottsdale, AZ, ⁴Mayo Clinic Rochester, Rochester, MN
*Purpose: Rehospitalizations are common after kidney transplantation (KT) and associated with increased cost, allograft failure, and death. Physical frailty as defined by Fried criteria has…
2022 American Transplant Congress
Evolution of Donor-Derived Cell-Free DNA During the First Week After Surgery Predicts Renal Function Recovery After Kidney Transplantation
D. Cucchiari¹, E. Cuadrado¹, E. Gonzalez¹, J. Puig¹, M. Ramirez-Bajo¹, P. Ventura-Aguiar¹, I. Revuelta², B. Bayès¹, F. Diekmann¹
¹Hospital Clínic de Barcelona, Barcelona, Spain, ²Hospital Clinic de Barcelona, Barcelona, Spain
*Purpose: Donor-derived cell-free DNA (ddcfDNA) is usually employed starting from the second week after kidney transplantation (KT), as its earlier increase can be due to…
2022 American Transplant Congress
The Effect of Bariatric Surgery Pre-Transplant on Renal Transplant Outcomes
R. Zaminpeyma, S. Negi, N. Saberi, A. Andalib, S. Paraskevas, J. Tchervenkov
Surgery, McGill, Montreal, QC, Canada
*Purpose: We compared post-transplant outcomes in patients with morbid obesity undergoing pre-transplant bariatric surgery to non-obese and obese patients without bariatric surgery.*Methods: Adult recipients of…