Articles tagged "Kidney transplantation"

2018 American Transplant Congress
As Clear as Mud: Volatility of the Five-Tier Quality Assessment of Kidney Transplant Centers in the United States
J. Schold,¹ K. Andreoni,² A. Chandraker,³ R. Gaston,⁴ J. Locke,⁴ A. Mathur,⁵ T. Pruett,⁶ A. Rana,⁷ L. Ratner,⁸ L. Buccini.¹
¹Cleveland Clinic, Cleveland; ²University of Florida, Gainesville; ³Harvard Medical School, Boston; ⁴University of Alabama at Birmingham, Birmingham; ⁵Mayo Clinic, Phoenix; ⁶University of Minnesota, Minneapolis; ⁷Baylor College of Medicine, Houston; ⁸Columbia University, New York.
Outcomes of patients receiving transplants in the US are systematically aggregated into bi-annual Program-Specific Reports(PSRs) detailing risk-adjusted survival by transplant center. Recently the SRTR issued…
2018 American Transplant Congress
Acute Tubular and Glomerular Kidney Injury Markers Reflect Ischemia-Reperfusion and Rejection
Y. Shim, R. Fan, N. Dvorina, W. Baldwin.
Immunology, Cleveland Clinic, Cleveland, OH.
Reliable markers of early acute injury following renal transplantation would enable timely therapeutic interventions. Standard serum creatinine and blood urea nitrogen measurements increase only after…
2018 American Transplant Congress
Peripheral Blood Immune Response-Related Gene Analysis for Evaluating the Development of Subclinical Antibody-Mediated Rejection
T. Yamamoto,¹ K. Iwasaki,² K. Murotani,³ A. Takeda,⁴ M. Tsujita,⁴ T. Hiramitsu,⁴ N. Goto,⁴ S. Narumi,⁴ Y. Watarai,⁴ K. Uchida,² T. Kobayashi.⁵
¹Xenotransplantation, University of Alabama at Birmingham, Birmingham, AL; ²Kidney Disease and Transplant Immunology, Aichi Medical University, Nagakute, Japan; ³Biostatistics, Aichi Medical University, Nagakute, Japan; ⁴Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ⁵Renal Transplant Surgery, Aichi Medical University, Nagakute, Japan.
Background: Noninvasive methods for the early diagnosis of chronic antibody-mediated rejection (cAMR) are desired for patients with de novo (dn) donor-specific HLA antibody (DSA) because…
2018 American Transplant Congress
Repeat Kidney Transplant Patients with Active Rejection Have Elevated Donor-Derived Cell-Free DNA
S. Mehta,¹ J. Chang,² T. Hailey,¹ D. Hiller,³ M. Grskovic,³ J. Yee,³ R. Mannon.¹
¹University of Alabama School of Medicine, Birmingham, AL; ²Columbia University Medical Center, New York, NY; ³CareDx, Brisbane, CA.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is an established marker of active rejection in de novo kidney transplant recipients. Here we characterize dd-cfDNA in patients who…
2018 American Transplant Congress
Is the NETos Increased in Acute Antibody Mediated Rejection?
R. Villca-Gonzales,¹ J. Torres-Ruiz,² D. Gomez-Martin,² J. Alberu,³ L. Morales-Buenrostro.¹
¹Nephrology, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico; ²Immunology, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico; ³Transplantation, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico.
Neutrophils can promote graft inflammation through a form of programmed cell death termed "NETosis". How alloantibodies contribute to neutrophil responses in grafts is not clear…
2018 American Transplant Congress
Mid-Term Outcome of Donor Specific Antibody Positive Deceased Donor Kidney Transplantation with Peri-Transplant Desensitization
K. Osickova,¹ P. Hruba,² J. Slatinska,¹ A. Slavcev,² J. Fronek,² E. Honsova,² O. Viklicky.¹
¹Dept. of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ²Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Donor specific HLA-antibodies (DSA) remain a large barrier to successful kidney transplantation and there is a limited knowledge about desensitization strategies in deceased donor programs.Anti…
2018 American Transplant Congress
Impact of Pneumocystis Prophylaxis on Incidence of Treated Urinary Tract Infections Following Kidney Transplantation
S. Sanchez, M. Brokhof, N. Kenyon, C. Varughese, N. Alvey.
Rush University Medical Center, Chicago, IL.
Background: Urinary tract infection (UTI) is the most common infectious complication after kidney transplantation resulting in increased morbidity and mortality. Sulfamethoxazole[mdash]trimethoprim (SMX-TMP) is commonly used…
2018 American Transplant Congress
Single-Center Experience with Sofosbuvir-Based HCV Treatment after Kidney Transplantation
V. Garcia, G. Meinerz, C. da Silva, R. Bruno, E. Keitel.
Nephrology and Kidney Transplant Department, ISCMPA, Porto Alegre, Brazil.
Chronic hepatitis C (HCV) infection is an important clinical challenge after kidney transplantation. This is the initial report of a single-center experience with sofosbuvir-based HCV…
2018 American Transplant Congress
Evaluation of Salt Intake by 24-h Urinary Sodium Excretion in Kidney Transplant Patients
T. Abe,¹ M. Kawamura,¹ S. Nakazawa,¹ T. Kato,¹ R. Imamura,¹ N. Ichimaru,² S. Takahara,² N. Nonomura.¹
¹Departments of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; ²Departments of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Background: Dietary recommendations for chronic kidney disease advise 3 to 6 g/day of dietary salt intake. We evaluated current adherence to dietary recommendations for CKD…
2018 American Transplant Congress
Impact of Balanced Solutions on Acid Base Disorders during and after Kidney Transplantation
N. Maillard,² H. Chraka,¹ G. Claisse,² E. Alamartine,² S. Molliex,¹ C. Mariat.²
¹Département d'Anesthésie Réanimation, CHU Saint Etienne, Saint Etienne, France; ²Service de Néphrologie Dialyse Transplantation Rénale, CHU Saint Etienne, Saint Etienne, France.
Fluid management of peri operative period of kidney transplantation is crucial to drive volemia, acid/base and electrolyte balance, as renal function is usually absent or…