Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Combination Proteasome Inhibition and Anti-BAFF Therapy Permits Highly Sensitized Rhesus Kidney Transplantation
B. Ezekian, J. Kwun, M. Manook, P. Schroder, J. Yoon, M. Mulvihill, K. Freischlag, J. Park, J. Cochran, K. Kroning, J. Yi, S. Knechtle.
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:HLA-sensitization is a significant immunologic barrier to successful kidney transplantation (KT). We have shown that proteasome inhibition (PI) in insolation reduces plasma cells (PCs), but…
2018 American Transplant Congress
Treatment of Active Chronic Antibody-Mediated Rejection with Rituximab, IVIG and Plasma Exchange
G. Piñeiro,¹ J. Rovira,² E. De Sousa-Amorim,¹ J. Villarreal,¹ M. Sole,³ I. Revuelta,¹ M. Lozano,⁴ E. Palou,⁴ F. Oppenheimer,¹ J. Campistol,¹ F. Diekmann.^1,2
¹Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Barcelona, Spain; ²Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; ³Pathology, Hospital Clinic de Barcelona, Barcelona, Spain; ⁴Apheresis Unit, Hemotherapy and Hemostasis, Hospital Clinic de Barcelona, Barcelona, Spain; ⁵Immunology, Hospital Clinic de Barcelona, Barcelona, Spain.
Chronic antibody-mediated rejection (cABMR) and transplant glomerulopathy (TG) are main features associated with long-term graft loss. Despite its clinical significance, the available evidence on treatment…
2018 American Transplant Congress
Non-Medical Factors Predict Receipt and Type of Kidney Transplant in Veterans
K. Kendall, X. Li, C.-C. Chang, J. Pleis, E. Croswell, M. Dew, G. Switzer, A. Langone, A. Mittal-Henkle, S. Saha, M. Ramkumar, J. Adams-Flohr, C. Thomas, L. Myaskovsky.
VA Kidney Transplant Centers: IA, OR, PA, TN, Iowa City, Portland, Pittsburgh, Nashville.
Background: African Americans, Hispanic Americans and other minorities have a higher incidence of end-stage kidney disease but lower rates of both deceased and living donor…
2018 American Transplant Congress
The Influence of a Conversion to Sirolimus-Based Immunosuppression on Non-Melanomatous Skin Cancer Incidence in Kidney Transplant Recipients over Long Term Follow Up
F. Daly,¹ P. O'Kelly,¹ F. Moloney,² D. Sexton,¹ P. Conlon.¹
¹Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland; ²Department of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland.
Background: The CONVERT trial found a reduced incidence of malignancy amongst renal transplant recipients over 2 years of follow up with a conversion from calcineurin…
2018 American Transplant Congress
Factor Analysis (FA) of Renal Transplant Biopsy (KTxBx) Data Enables Objective Assessment of Risk for Subsequent Death Censored Graft Failure (DCGF)
L. Hunsicker,¹ J. Grande,² J. Cecka,³ A. Matas,⁴ The DeKaf Consortium.
¹Int. Med., UIowa, Iowa City, IA; ²Pathology, Mayo Clinic, Rochester, MN; ³Immunogenetics, UCLA, Los Angeles, CA; ⁴Surgery, U Minnesota, Minneapolis, MN.
We examined the impact of five axes of injury identified by FA in the KTxBx on the hazard for subsequent DCGF in two DeKAF cohorts.Methods:…
2018 American Transplant Congress
Prevention of New Onset Diabetes after Transplantation Using Bariatric Surgery
A. Bailey, Y. Kim, S. Woodle, S. Shah, F. Paterno, M. Cuffy, T. Diwan.
Transplant Surgery, University of Cincinnati, Cincinnati, OH.
New onset diabetes after transplantation (NODAT) is a common complication, occurring 20-36% after renal transplant historically and 15.8% at our institution. Obesity is a known…
2018 American Transplant Congress
Using the Explore Transplant Ontario Program to Increase Transplant Knowledge and Readiness among Patients on Maintenance Dialysis
D. Belenko,¹ C. Richardson,¹ V. Gupta,¹ T. Ahmed, N. Edwards, M. Novak,² J. Peipert,³ A. Waterman, I. Mucsi.
¹Multi-Organ Transplant Program, Department of Surgery, University Health Network, Toronto, ON, Canada; ²Department of Psychiatry, University of Toronto, Toronto, ON, Canada; ³David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
IntroductionKidney transplantation (KT) is the preferred treatment for patients with End-Stage Kidney Disease (ESKD), yet many potentially eligible patients do not act to pursue KT.…
2018 American Transplant Congress
Clinical Impact of Denovo or Recurrent Donor Specific Antibodies in the First Year Post Kidney Transplant in Patients on Early Steroid Withdrawal Immunosupression Regimen
O. Adebiyi, T. Taber, W. Goggins, D. Mishler, M. Yaqub, A. Sharfuddin.
Division of Renal Disease and Hypertension, Indiana University Health, Indianapolis, IN.
Background: Immunologic risk monitoring of recipients of kidney transplant(Tx) using donor specific antibodies (DSA) has become a standard practice in most Tx centers in the…
2018 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish BK Virus Nephropathy from Acute Rejection in Kidney Transplant Patients with Graft Dysfunction
K. Keslar,¹ P. Gotwald,¹ W. Xu,² A. Zmijewska,³ J. Chen,³ K. Newell,⁴ P. Heeger,⁵ J. Bromberg,⁶ R. Mannon,³ R. Fairchild,¹ The CTOT Consortium.
¹Cleveland Clinic, Cleveland, OH; ²Nanostring Technologies, Seattle, WA; ³University of Alabama at Birmingham, Birmingham, AL; ⁴Emory University, Atlanta, GA; ⁵Icahn School of Medicine at Mt. Sinai, New York, NY; ⁶University of Maryland, Baltimore, MD.
Acute cellular rejection and BK virus nephropathy both cause deteriorating graft function that can lead to graft loss. Distinguishing the two conditions rapidly and accurately…
2018 American Transplant Congress
Role of C1q-Binding Donor-Specific Anti-HLA Antibodies in Premature and Accelerated Kidney Allograft Interstitial Fibrosis
K. Louis, D. Viglietti, O. Aubert, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France.
The 2017 Banff meeting has focused on the importance of a precise diagnosis of IF/TA in kidney recipients by addressing specific etiological factors. Recent studies…