Articles tagged "Kidney transplantation"

2018 American Transplant Congress
In-Situ Tissue-Based Gene Expression Profiling is a Reliable Method to Detect Gene Transcripts in Human Kidney Transplant Biopsies
D. Dobi,¹ J. Henrik,² T. Sigdel,² A. Chen,¹ Z. Laszik.¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, University of California, San Francisco, San Francisco, CA.
Purpose. Validation studies that would enable the clinical application of quantitative in situ tissue-based gene expression profiling in renal transplantation are lacking. In this study,…
2018 American Transplant Congress
False-Positive Flow-Cytometric T Cell Crossmatch Associated with Blood Type Antigen Expressed on Lymphocytes in ABO Incompatible Kidney Transplantation
D. Iwami,¹ M. Ito,² K. Hotta,¹ H. Higuchi,¹ N. Shinohara.¹
¹Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan; ²Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
Background: Flow-cytometric T cell crossmatch (FTXM) uses live donor lymphocytes to detect anti-donor-human leukocyte antigen (HLA) IgG antibodies. Therefore, the results can be affected by…
2018 American Transplant Congress
Early Experience Using Donor-Derived Cell-Free DNA for Detection of Rejection in Kidney Transplantation
E. Huang, A. Vo, J. Choi, A. Peng, S. Sethi, R. Najjar, S. Jordan.
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction:Donor-derived cell free DNA (ddDNA; Allosure, CareDX) has been validated as a non-invasive test that can discriminate rejection from non-rejection in kidney transplantation, but has…
2018 American Transplant Congress
Immunologic Impact of Tocilizumab Treatment in Kidney Transplant Recipients with Allograft Inflammation
J. Leung, S. Chandran, F. Vincenti, Q. Tang.
UCSF, San Francisco.
Background: Proinflammatory cytokine IL-6 increases effector/memory T-cells, induces Th17 cells and prevents the induction of Tregs. IL-6 expression in kidney biopsies is elevated during acute…
2018 American Transplant Congress
Interactive Software for Simulation and Management of a Kidney Paired Donation Program
M. Bray,¹ W. Wang,¹ M. Rees,² P. Song,¹ A. Leichtman,³ V. Ashby,¹ J. Kalbfleisch.¹
¹University of Michigan, Ann Arbor, MI; ²Alliance for Paired Donation, Maumee, OH; ³Arbor Research, Ann Arbor, MI.
In kidney paired donation (KPD), candidates with willing but incompatible donors are pooled together with the goal of finding new transplant opportunities by exchanging donors.…
2018 American Transplant Congress
Long-Term Outcome of Kidney Transplant Recipient with HTLV-1 Infection
N. Goto,¹ M. Minami,¹ K. Futamura,² M. Okada,¹ M. Tsujita,¹ T. Hiramitsu,² S. Narumi,² Y. Watarai.²
¹Nagoya Daini Red Cross Hospital, Transplant Nephrology, Nagoya, Japan; ²Nagoya Daini Red Cross Hospital, Transplant Surgery, Nagoya, Japan.
BackgroundThe human T-lymphotropic virus (HTLV-I), which is endemic in southern Japan, is recognized as the cause of adult T cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy…
2018 American Transplant Congress
Pre-Transplant Duration of Dialysis, N-Terminal Pro-Brain Natriuretic Peptide and Post-Transplant Mortality in Renal Transplant Recipients
M. Yeung, M. Van Londen, U. Nakshbandi, Y. Said, M. Eisenga, B. Hepkema, M. Nolte, S. Berger, M. De Borst, S. Bakker.
Internal Medicine Department, Division Nephrology, University Medical Center Groningen, Groningen, Netherlands.
Background and objective: Pre-transplant dialysis duration (DD) is associated with increased mortality in renal transplant recipients (RTRs) due to accelerated atherosclerosis, intradialytic volume overload and…
2018 American Transplant Congress
Low Serum 3-Methyl Histidine Level is Associated with Peripheral Arterial Stiffness in Renal Transplant Recipients
B-.G. Hsu,^1,4 Y-.H. Lai,¹ J. Hou,¹ C-.H. Liu,³ M-.C. Lee.^2,4
¹Nephrology, Tzu Chi General Hospital, Hualien, Taiwan; ²Surgery, Tzu Chi General Hospital, Hualien, Taiwan; ³Pharmacology, Tzu Chi University, Hualien, Taiwan; ⁴School of Medicine, Tzu Chi University, Hualien, Taiwan.
Introduction:3-methyl histidine (3MH) is a non-proteinogenic amino acid and an index of muscle breakdown. Subclinical protein malnutrition is an independent association with arterial stiffness. The…
2018 American Transplant Congress
Racial and Socioeconomic Influences on Kidney Transplantation. A 10 Year Retrospective Study
A. Arvelakis, S. Lerner, V. Wadhera, V. Delaney, S. Ames, V. Shegal, R. Kent, G. DeBoccardo, N. Singh, S. Florman, R. Shapiro.
Recanati/Miller Transplantation Institute, The Mount Sinai Hospital, New York, NY.
Introduction: Racial disparities in kidney transplantation are a widely discussed topic. Studies have shown less access to listing and transplantation, and worse graft survival in…
2018 American Transplant Congress
Tomotherapy and Donor Hematopoietic Cells for Tolerance to Kidney Transplants in Rhesus Macaques
D. Kaufman,¹ L. Haynes,¹ P. Hematti,¹ W. Burlingham,¹ L. Forest,² J. Post,¹ R. Redfield,¹ L. Fernandez,¹ A. D'Alessandro,¹ J. Haynes,¹ K. Jensen,³ S. Strober.³
¹Surgery, University of Wisconsin School of Medicine, Madison, WI; ²Surgical Sciences, University of Wisconsin School of Vet Med, Madison, WI; ³Medicine, Stanford University Medical School, Palo Alto, CA.
The goal of this project was to develop a tolerance induction protocol for MHC 1-haplotype mismatched kidney transplants (txs) in a rhesus macaque model. The…