Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Blood Profiling Reflects a Significant Down-Regulation in Oxidative Phosphorylation Following Renal Transplantation with DCD and AKI Allografts
S. Walker¹, L. Cox², C. Langefeld², B. Freedman², A. Farney², J. Rogers², C. Jay², R. Stratta², G. Orlando²
¹Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, ²Wake Forest Baptist Medical Center, Winston Salem, NC
*Purpose: The human kidney transplant (KT) patient provides a unique and compelling in situ model system to study molecular events that underlie graft recovery following…
2019 American Transplant Congress
Accelerating Kidney Allocation: Simultaneously Expiring Offers
M. Kosztowski¹, M. Mankowski², S. Raghavan³, J. Garonzik-Wang¹, D. Axelrod⁴, D. L. Segev¹, S. E. Gentry¹
¹Johns Hopkins University, Baltimore, MD, ²King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, ³University of Maryland, College Park, MD, ⁴University of Iowa, Iowa City, IA
*Purpose: Placing kidneys quickly might reduce discard. Additionally, a faster allocation system that reduces cold ischemia time would yield benefits: decreased delayed graft function, shorter…
2019 American Transplant Congress
Simultaneous Robotic Kidney Transplantation and Bariatric Surgery for Morbidly Obese Patients with End-Stage Renal Failure
P. West-Thielke, K. A. Tulla, O. T. Okoye, J. A. Almario Alvarez, M. Spaggiari, I. G. Tzvetanov, E. Benedetti
University of Illinois at Chicago, Chicago, IL
*Purpose: The purpose of this study is to evaluate the safety and efficacy of simultaneous robotic assisted kidney transplant and robotic assisted sleeve in obese…
2019 American Transplant Congress
What’s in a High Dose? An Analysis of Tacrolimus Pharmacokinetic Parameters in Rapid Metabolizers
P. West-Thielke¹, A. Maldonado², S. J. Patel³, D. R. Stevens³, U. Meier-Kriesche³, D. Brennan⁴
¹University of Illinois, Chicago, Chicago, IL, ²Vidant Medical Center, Greenville, NC, ³Veloxis Pharmaceuticals Inc., Cary, NC, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: CYP3A5*1 expressers exhibit differences in immediate-release tacrolimus (IR-Tac) PK and require higher doses of IR-Tac to maintain therapeutic trough concentrations. LCP-Tacrolimus (LCPT) demonstrates a…
2018 American Transplant Congress
Ischemia Reperfusion Injury & Risk for Antibody Mediated Rejection (ABMR) in HLA Sensitized Patients Treated with C1 Esterase Inhibitor (C1INH)
A. Vo,¹ O. Aubert,² J. Choi,¹ N. Ammerman,¹ H. Edmund,¹ A. Peng,¹ R. Najjar,¹ S. Supreet,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; ²Paris Translational Research for Organ Transplantation, Necker Hospital, Paris, France.
Introduction: Ischemia reperfusion injury (IRI) contributes to delayed graft function (DGF). IRI/DGF in HLA-sensitized (HS) patients likely activates innate and memory injury pathways that may…
2018 American Transplant Congress
Effect of Everolimus with Reduced Calcineurin Inhibitor on Efficacy and Safety in De Novo Kidney Transplant Recipients: 12-Month Results from the US Cohort of TRANSFORM Study
S. Mulgaonkar,¹ Y. Qazi,¹ D. Kim,¹ V. Peddi,¹ K. McCague,² D. Patel,² A. Wiseman.¹
¹TRANSFORM Study Group, Livingston; ²Novartis Pharmaceuticals Corporation, East Hanover.
Purpose: Despite remarkable short-term survival benefits, long-term outcomes in kidney transplant recipients (KTRs) remain unsatisfactory. Everolimus (EVR) may improve long-term outcomes by reducing calcineurin inhibitor…
2018 American Transplant Congress
Molecular Profiling of the Injury-Repair Response in Early Subclinical Inflammation
M. Seifert, D. Della Manna, X. Liu, F. Rosenblum, M. Yanik, E. Yang, J. Pollock, R. Mannon.
UAB School of Medicine, Birmingham.
Purpose: Surveillance biopsies can detect subclinical T-cell mediated rejection (SC-TCMR) or subclinical borderline rejection (SC-B-TCMR) in kidney transplants with normal/stable creatinine. Some consider SC-B-TCMR to…
2018 American Transplant Congress
Belatacept Maintenance Immunosuppression Use and Outcomes in the Real-World Clinical Setting Using OPTN/UNOS Kidney Transplant Registry
S. Sanoff,¹ K. Ravindra,¹ W. Irish.^1,2
¹Duke University Medical Center, Durham, NC; ²CTI Consulting, Raleigh, NC.
Introduction:Belatacept (BEL) was FDA approved for Kidney Transplantation (KTx) June 2011. It has largely been evaluated in two controlled trials (N Engl J Med 2016;374:333-43).…
2018 American Transplant Congress
Evolving Etiologies for Readmissions and Their Impact on Graft Survival in Kidney Transplantation
D. Taber, N. Pilch, Z. Su, C. Mardis, J. Fleming, N. Patel, H. Meadows, P. Mauldin, V. Rao, D. Dubay.
MUSC, Charleston, SC.
Background: Although readmissions after kidney transplant are a well-known risk factor for graft loss, it is unclear if certain etiologies are associated with poorer outcomes…
2018 American Transplant Congress
Kidney Transplant Allocation with CMV Seromatching Reduces CMV Infection without Affecting Wait Times
A. Narra,¹ L. Strasfeld,² D. Basuli,¹ M. Stack,¹ E. Langewisch,³ A. Olyaei,¹ D. Norman,^1,4 J. Lockridge.^1,4
¹Transplant Nephrology, Oregon Health and Science University, Portland, OR; ²Infectious Diseases, OHSU, Portland, OR; ³Transplant Nephrology, University of Nebraska Medical Center, Omaha, NE; ⁴Transplant Nephrology, Portland VA, Portland, OR.
Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in kidney transplant recipients.A pre-transplant allocation strategy by matching deceased kidney donors and recipients…