Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Opioid Minimization in Kidney Transplant: Achievable Quicker Than You Think
J. N. Fleming, N. Patel, H. Gonzales, N. A. Pilch, S. Parks, C. Perez, P. K. Baliga, S. N. Nadig, D. J. Taber, V. Rohan
Medical University of South Carolina, Charleston, SC
*Purpose: Opioid use after kidney transplant has been shown to be a risk factor for chronic opioid use, which leads to an increased risk of…
2019 American Transplant Congress
Quantitative Proteome Profiling in T Cell-Mediated Rejection
L. Song¹, G. Zeng², P. Liu³, F. Fang⁴, H. Liu⁴, X. Xie¹, P. Randhawa², K. Xiao⁴
¹Department of Urological Organ Transplantation, The Second Xiangya Hospital, Central-South University, Changsha, China, ²Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Department of Biostatistics, Graduate School of Public Health, and Departments of Pharmacology and P, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA
*Purpose: The proteomic analyses through formalin-fixation and paraffin embedding (FFPE) specimens reflects systemic and inherent renal injury perturbations for different kidney transplant injury states. In…
2019 American Transplant Congress
Novel Molecular Mechanisms Associated with Normothermic Ex-Vivo Kidney Perfusion
C. McEvoy¹, T. Tokar², S. Reid³, P. Urbanellis³, M. Hamar¹, M. Kaths¹, I. Jurisica², L. Robinson⁴, M. Selzner¹, A. Konvalinka¹
¹MOT Programme, University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, UHN, Toronto, ON, Canada, ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁴Sick Kids Research Institute, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) is associated with significantly improved graft function following transplantation in comparison to static cold storage (SCS), however the molecular…
2019 American Transplant Congress
Surveillance Biopsy Utilization Reported Higher In Transplant Centers Performing Over 100 Kidney Transplants Per Year.
D. M. Lee¹, R. First¹, S. Rose¹, M. Abecassis²
¹Transplant Genomics Inc, Mansfield, MA, ²Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: To assess the frequency of surveillance biopsies in kidney transplant patients in transplant centers performing greater than 100 transplants per year, and to compare…
2019 American Transplant Congress
Multiple Non-HLA Antibodies Are Significantly Increased in Chronic Active Antibody Mediated Rejection
K. Sablik¹, E. Kamburova², D. Roelen³, H. Otten², M. Betjes¹
¹Erasmus MC, Rotterdam, Netherlands, ²University Medical Center Utrecht, Utrecht, Netherlands, ³University Medical Center Leiden, Leiden, Netherlands
*Purpose: Chronic-active antibody mediated rejection (c-aABMR) is characterized by continuous inflammation at the level of the microvascular endothelium. Although donor-specific anti-HLA antibodies play an important…
2019 American Transplant Congress
The Impact of KDPI on Post Transplant Kidney Function: Intercept versus Slope. A Single Center Study
M. Molinari¹, D. Jorgensen², R. Mehta³, P. Sood³, A. Ganoza², C. Puttarajappa³, R. Lopez², M. Wijkstrom², A. Tevar², S. Hariharan³
¹University of Pittsburgh Medical Centre, Pittsburgh, PA, ²Surgery, University of Pittsburgh Medical Centre, Pittsburgh, PA, ³Medicine, University of Pittsburgh Medical Centre, Pittsburgh, PA
*Purpose: We evaluated the impact of Kidney Donor Profile Index (KDPI) on post-transplant renal function and graft survival.*Methods: Between January-2013 and December- 2017, a total…
2019 American Transplant Congress
Time within Therapeutic Range: A Comparison of Three Tacrolimus Formulations within Ninety Days of Renal Transplant
S. Patel, K. Khalil, A. Lichvar, E. Benedetti, P. West-Thielke
University of Illinois Hospital and Health Sciences System, Chicago, IL
*Purpose: Optimizing tacrolimus (TAC) time within therapeutic range (TTR) has been shown to improve outcomes post-transplant. To date, there are no studies assessing differences in…
2019 American Transplant Congress
Delayed Achievement of Therapeutic Tacrolimus Levels with De Novo Extended-Release Tacrolimus Tablets and the Incidence of Rejection in Kidney Transplant Patients
C. E. Carthon¹, J. C. Hagopian¹, S. E. January¹, A. Gharabagi¹, R. Delos Santos², T. A. Horwedel³
¹Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, ²Nephrology, Washington University School of Medicine, Saint Louis, MO, ³Veloxis Pharmaceuticals, Inc., Cary, NC
*Purpose: Early therapeutic tacrolimus levels have been associated with improved outcomes in renal transplant recipients while lower exposure to tacrolimus during the first week of…
2019 American Transplant Congress
Syphilis Transmission in Solid Organ Transplantation
M. Morrison, M. Hurtik, G. M. Lyon, S. Pouch
Emory University Hospital, Atlanta, GA
*Purpose: Syphilis is a sexually transmitted infection that affects people worldwide. While transmission generally occurs via sexual contact, other modes of transmission are possible, including…
2019 American Transplant Congress
miRNA Signatures as Prediction Tool for DSA Development and Rejection
M. Hamdorf¹, L. M. Rebellato², K. P. Briley², M. J. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC
*Purpose: Early and convenient diagnosis is urgently needed for acute and chronic transplant rejection due to its high risk of the loss of the transplant.…