Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Response to Treatment in Kidney Recipients with Acute T Cell-Mediated Rejection: Major Impact of Inflammation in Sclerotic Cortical Parenchyma (i-IF/TA) and Donor-Specific Antibodies
Y. Bouatou, D. Viglietti, D. Pievani, J. Duong Van Huyen, O. Aubert, D. Glotz, C. Legendre, A. Loupy, C. Lefaucheur
Paris Translational Research Center for Organ Transplantation, Paris, France
*Purpose: The recent recognition of chronic TCMR phenotypes has fostered the need to better evaluate the response of acute TCMR to standard-of-care treatment.*Methods: Among 2905…
2019 American Transplant Congress
A Potential Role for IgE-Mediated Immune Response in the Pathogenesis of Chronic Antibody-Mediated Rejection
F. Rascio¹, P. Pontrelli², G. S. Netti³, E. Manno¹, B. Infante¹, S. Simone², G. Castellano², M. Seveso⁴, E. Cozzi⁴, L. Gesualdo², G. Stallone¹, G. Grandaliano¹
¹Department of Medical and Surgical Sciences, Nephrology Dialysis and Transplantation Unit, University of Foggia, Foggia, Italy, ²Department of Emergency, and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy, ³Dept. of Medical and Surgical Sciences, Clinical Pathology Unit, University of Foggia, Foggia, Italy, ⁴Department of Cardiac, Thoracic and Vascular Sciences, Transplant Immunology Unit, University of Padua, Padova, Italy
*Purpose: Chronic antibody-mediated rejection (CAMR) is the main cause of graft loss and shares with systemic lupus erythematosus (SLE) the antibody-mediated kidney damage and the…
2019 American Transplant Congress
Increasing Time-in-Therapeutic Range of Tacrolimus is Associated with Superior Outcomes in Living Kidney Transplants
T. Lin, T. Song, S. Yin, Y. Jiang, Z. Huang, X. Wang, J. Liu, Z. Wang
Organ Transplantation Center, Urology Department, Urology Research Institute, WestChina Hospital, Sichuan University, Chengdu, China
*Purpose: Tacrolimus-based regimens remain the backbone of maintenance immunosuppressive therapy in kidney transplant, and therapeutic drug monitoring of tacrolimus is necessary due to a narrow…
2019 American Transplant Congress
The Model For Predicting eGFR At A Year After Donation In Living Related Kidney Transplant Donors
K. Shinoda, K. Sakurabayashi, T. Mizutani, Y. Takahashi, Y. Hyodo, Y. Itabashi, M. Muramatsu, T. Kawamura, S. Shishido, K. Sakai
Nephrology, Toho University Faculty of Medicine, Tokyo, Japan
*Purpose: Predicting post-donation kidney function precisely is considerably beneficial for both candidates of living-related kidney donors and their physicians when judging the feasibility of kidney…
2019 American Transplant Congress
Opioid Minimization in Kidney Transplant: Achievable Quicker Than You Think
J. N. Fleming, N. Patel, H. Gonzales, N. A. Pilch, S. Parks, C. Perez, P. K. Baliga, S. N. Nadig, D. J. Taber, V. Rohan
Medical University of South Carolina, Charleston, SC
*Purpose: Opioid use after kidney transplant has been shown to be a risk factor for chronic opioid use, which leads to an increased risk of…
2019 American Transplant Congress
Quantitative Proteome Profiling in T Cell-Mediated Rejection
L. Song¹, G. Zeng², P. Liu³, F. Fang⁴, H. Liu⁴, X. Xie¹, P. Randhawa², K. Xiao⁴
¹Department of Urological Organ Transplantation, The Second Xiangya Hospital, Central-South University, Changsha, China, ²Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Department of Biostatistics, Graduate School of Public Health, and Departments of Pharmacology and P, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA
*Purpose: The proteomic analyses through formalin-fixation and paraffin embedding (FFPE) specimens reflects systemic and inherent renal injury perturbations for different kidney transplant injury states. In…
2019 American Transplant Congress
Novel Molecular Mechanisms Associated with Normothermic Ex-Vivo Kidney Perfusion
C. McEvoy¹, T. Tokar², S. Reid³, P. Urbanellis³, M. Hamar¹, M. Kaths¹, I. Jurisica², L. Robinson⁴, M. Selzner¹, A. Konvalinka¹
¹MOT Programme, University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, UHN, Toronto, ON, Canada, ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁴Sick Kids Research Institute, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) is associated with significantly improved graft function following transplantation in comparison to static cold storage (SCS), however the molecular…
2019 American Transplant Congress
Surveillance Biopsy Utilization Reported Higher In Transplant Centers Performing Over 100 Kidney Transplants Per Year.
D. M. Lee¹, R. First¹, S. Rose¹, M. Abecassis²
¹Transplant Genomics Inc, Mansfield, MA, ²Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: To assess the frequency of surveillance biopsies in kidney transplant patients in transplant centers performing greater than 100 transplants per year, and to compare…
2019 American Transplant Congress
Multiple Non-HLA Antibodies Are Significantly Increased in Chronic Active Antibody Mediated Rejection
K. Sablik¹, E. Kamburova², D. Roelen³, H. Otten², M. Betjes¹
¹Erasmus MC, Rotterdam, Netherlands, ²University Medical Center Utrecht, Utrecht, Netherlands, ³University Medical Center Leiden, Leiden, Netherlands
*Purpose: Chronic-active antibody mediated rejection (c-aABMR) is characterized by continuous inflammation at the level of the microvascular endothelium. Although donor-specific anti-HLA antibodies play an important…
2019 American Transplant Congress
The Impact of KDPI on Post Transplant Kidney Function: Intercept versus Slope. A Single Center Study
M. Molinari¹, D. Jorgensen², R. Mehta³, P. Sood³, A. Ganoza², C. Puttarajappa³, R. Lopez², M. Wijkstrom², A. Tevar², S. Hariharan³
¹University of Pittsburgh Medical Centre, Pittsburgh, PA, ²Surgery, University of Pittsburgh Medical Centre, Pittsburgh, PA, ³Medicine, University of Pittsburgh Medical Centre, Pittsburgh, PA
*Purpose: We evaluated the impact of Kidney Donor Profile Index (KDPI) on post-transplant renal function and graft survival.*Methods: Between January-2013 and December- 2017, a total…