Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Significantly High FOXP3 mRNA in the Renal Allograft as a Mechanism of Tolerance Induced by Transient Mixed Chimerism in Non-Human Primates
M. Matsunami¹, I. Rosales¹, T. Oura¹, B. Adam², M. Mengel², R. Smith¹, A. Cosimi¹, R. Colvin¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: Treg-rich organized lymphoid structures (TOLS) has been identified in recipients with renal allograft tolerance induced by transient mixed chimerism in non-human primates (NHPs) and…
2019 American Transplant Congress
Racial and Income-Based Disparities in Access to Kidney Transplantation in the Context of a Nationally-Financed Health System in Brazil
A. Saha¹, G. Ferreira², Y. Yu¹, M. Waldram¹, V. Colares², J. Bastos², M. Henderson¹, D. Segev¹, A. Massie¹
¹Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ²Santa Casa de Misericordia de Juiz de Fora, Juiz de Fora, Brazil
*Purpose: Changes in economic and social factors in low- and middle-income countries have led to rising burden of chronic disease. Brazil, a middle-income country with…
2019 American Transplant Congress
IgG Glycosylation Causes Podocyte Injury in Transplant Glomerulopathy through Calcium Calmodulin Kinase IV
R. Bhargava, K. Maeda, M. Pavlakis, G. Tsokos
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
*Purpose: Transplant glomerulopathy(TG) is a major cause of late allograft loss. Increase in urine podocin/creatinine ratio in TG signifies acceleration of podocyte detachment from glomerular…
2019 American Transplant Congress
Urinary Exosomal microRNA as a Non-Invasive Biomarker for the Diagnosis of Acute Rejection in Kidney Transplant Recipients
J. Seo¹, Y. Lee¹, S. Jung¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Nephrology, Kyung Hee University College of Medicine, Seoul, Korea, Republic of, ²Nephrology, Kyungpook National University College of Medicine, Daegu, Korea, Republic of, ³Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ⁴Nephrology, The St. Mary’s Hospital of Catholic University of Korea, Seoul, Korea, Republic of, ⁵Nephrology, Inje University College of Medicine, Busan, Korea, Republic of
*Purpose: Acute rejection (AR) is the main obstacle to the graft survival after kidney transplantation. Urinary exosome is a promising source of biomarker for various…
2019 American Transplant Congress
NK Cell Quantification by Paraffin Immunohistochemistry is Not Predictive of Graft Outcome in 1-Year Surveillance Biopsies
J. Barnes¹, F. Suliman², A. Shammout¹, E. A. Farkash¹
¹Pathology, Michigan Medicine, Ann Arbor, MI, ²Nephrology, Michigan Medicine, Ann Arbor, MI
*Purpose: Molecular and animal studies have identified NK cells as important mediators and markers of antibody mediated rejection. Using three color immunohistochemistry for CD16, T-bet,…
2019 American Transplant Congress
Increased Number of Intragraft FoxP3+ T Cells is Strongly Correlated with Decreased Graft Survival in Chronic Active Antibody Mediated Rejection
K. Sablik¹, K. Jordanova², M. Clahsen-van Groningen¹, M. Betjes¹
¹Erasmus MC, Rotterdam, Netherlands, ²Amsterdam UMC, Amsterdam, Netherlands
*Purpose: Chronic-active antibody-mediated rejection (c-aABMR) is the most important cause of late renal allograft failure. However, renal inflammation and rate of loss of renal allograft…
2019 American Transplant Congress
Estimated vs. Actual Graft Failure and Patient Survival after Kidney Transplantation
J. Buggs¹, T. Thigpen², E. Rogers¹, A. Kumar³, V. Bowers¹
¹Tampa General Hospital, Tampa, FL, ²Wesleyan College, Macon, GA, ³University of South Florida, Tampa, FL
*Purpose: The purpose of this study was to examine the difference between the estimated and actual values of graft survival and patient survival in kidney…
2019 American Transplant Congress
Evaluation of Envarsus XR in African American Kidney Transplant Recipients
L. R. Lineberger¹, E. Hollinger², N. Kenyon¹, M. Brokohf¹, N. Alvey¹
¹Pharmacy, Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Chicago, IL
*Purpose: This study is being conducted to evaluate the clinical impact of the utilization of tacrolimus LCP (TAC-LCP) compared to tacrolimus immediate release (TAC-IR) in…
2019 American Transplant Congress
Risk Factors for Initial Sub- and Supra-Therapeutic Tacrolimus Trough Levels in Renal Transplant Recipients
M. Kapugi, K. Cunningham, C. D'Agostino, C. Kane, A. Novak, J. Schulte
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Sub-therapeutic tacrolimus trough levels have been associated with increased risk of rejection in renal transplant recipients and supra-therapeutic levels with infectious risks and drug…
2019 American Transplant Congress
Inhibition of TLR4 Mediated Programmed Necrosis Does Not Improve Graft Function and Histology in a Murine Kidney Transplant Model
S. Jain¹, R. Plenter², T. Nydam², A. Jani¹
¹Renal Division, University of Colorado, Aurora, CO, ²Transplant Microsurgery Program, University of Colorado, Aurora, CO
*Purpose: Human Delayed Graft Function (DGF) is associated with upregulation of basolateral tubular TLR4 but whether TLR4 causes DGF is unknown. TLR4 has been shown…