Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Impact of Steroid-Free Protocol on Incidence of Posttransplantation Diabetes Mellitus: A Prospective, Randomized, Multicenter, Open-Label, Controlled Trial in Renal Transplant Recipients
J. Ekberg¹, S. Baid-Agrawal¹, B. Jespersen², R. Källén³, E. Rafael³, K. Skov², P. Lindnér¹
¹Institute of Clinical Sciences, Transplant Institute, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden, ²Department of Nephrology, Aarhus University Hospital, Aarhus, Denmark, ³Department of Transplantation, Skane University Hospital, Malmoe, Sweden
*Purpose: Comparison of two immunosuppressive protocols, steroid-free with antithymocyte globulin (ATG) induction, and steroid containing with basiliximab induction, regarding the incidence of PTDM, one year…
2019 American Transplant Congress
Potential Living Kidney Donors’ Interest in Kidney Paired and Non-Directed Donation
D. R. Helfer¹, A. D. Love¹, J. M. Konel¹, J. Stanton², M. G. Bowring¹, K. Kumar¹, S. R. Weeks¹, M. L. Henderson¹, D. L. Segev¹, A. M. Cameron¹, J. M. Garonzik Wang¹
¹Johns Hopkins University, Baltimore, MD, ²East Carolina University, Greenville, NC
*Purpose: Kidney Paired (KPD) and Non-Directed Donation (NDD) are avenues to increase living donation and address organ shortage. We investigated interest in KPD and NDD…
2019 American Transplant Congress
Circulating Mirnas Regulate Gene Expression In Kidney Tissue During Transplant Glomerulopathy
C. Kuscu¹, V. Sai Bontha¹, C. Kuscu¹, D. Maluf¹, A. Bajwa¹, J. Eason¹, V. Mas¹, E. Akalin²
¹UTHSC, Memphis, TN, ²Albert Einstein College of Medicine, NYC, NY
*Purpose: Post-transplant glomerular disease includes membranous glomerulopathy (MG), secondary or primary focal segmental glomerulosclerosis (FSGS). Furthermore, at post transplant, TG is an important cause of…
2019 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
K. Abou-Daya, D. Zhao, A. Williams, M. Oberbarnscheidt
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
2019 American Transplant Congress
A Prospective Randomized Multicenter Trial (B E S T Trial) of Belatacept-Based C N I- and Corticosteroid-Free Immunosuppression: Final Two Year Results
D. B. Kaufman¹, A. R. Shields², J. P. Leone³, A. Wiseman⁴, A. J. Matas⁵, P. West-Thielke⁶, J. Lipscomb², E. King², R. R. Alloway⁷, E. S. Woodle for the BEST Study Group²
¹University of Wisconsin, Madison, WI, ²University of Cincinnati, Cincinnati, OH, ³Tampa General, Tampa, FL, ⁴University of Colorado School of Medicine, Denver, CO, ⁵University of Minnesota, Minneapolis, MN, ⁶University of Illinois, Chicago, Chicago, IL, ⁷University of Cincinnati, Cincinnati, WI
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal Trial) is a prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based calcineurin inhibitor-free (CNI), early…
2019 American Transplant Congress
Increase in 48 Month Cumulative Acute Rejection Rates in the Most Recent Cohort: The 2018 Transplant Report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS)
V. Dharnidharka¹, C. Cramer², A. Chua³, A. Moudgil⁴, K. Martz⁵, T. Blydt-Hansen⁶, J. Smith⁷, A. Neu, on Behalf of The NAPRTCS Investigators⁸
¹Washington University in St. Louis, Saint Louis, MO, ²Mayo Clinic, Rochester, MN, ³Duke University, Durham, NC, ⁴Children's National Medical Center, Washington, DC, ⁵Emmes Corporation, Rockville, MD, ⁶BC Children's Hospital, Vancouver, BC, ⁷Seattle Children's Hospital, Seattle, WA, ⁸Johns Hopkins University, Baltimore, MD
*Purpose: The NAPRTCS registry has collected data on children receiving kidney transplants in North America since 1987. The registry has served to document and influence…
2019 American Transplant Congress
Tacrolimus Pharmacokinetics in Young, Middle Age and Older Renal Transplant Recipients- Impact of CYP3A5*3*6*7 Metabolic Composite
K. Tornatore¹, K. Attwood², D. Brazeau³, R. Venuto⁴
¹University at Buffalo; School of Pharmacy, Buffalo, NY, ²Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ³Marshall University; School of Medicine, Huntington, WV, ⁴University at Buffalo; School of Medicine, Buffalo, NY
*Purpose: In spite of increased renal transplantation in patients over 60 years and the need for age-adjusted tacrolimus maintenance immunosuppression, limited pharmacokinetic comparisons between young,…
2019 American Transplant Congress
Impact of Race and Substance Use on Listing Decisions for Kidney Transplant
R. N. DeBlasio¹, L. Myaskovsky², K. Kendall¹, A. DiMartini¹, G. Switzer¹, D. M. Posluszny¹, C. Puttarajappa¹, A. D. Tevar¹, S. Hariharan¹, R. Shapiro³, M. A. Dew¹
¹U Pittsburgh, Pittsburgh, PA, ²U New Mexico, Albuquerque, NM, ³Mt Sinai Recanati/Miller Transplantation Institute, New York, NY
*Purpose: Racial/ethnic minority patients face reduced access to kidney transplantation. We hypothesized that this disparity may be magnified if patients also have major psychosocial liabilities…
2019 American Transplant Congress
Extracellular Vesicles (EV) Mediate Antibody-Independent Tubular Senescence via Cyclin-Dependent Kinase Inhibitors p21/p16 in Antibody-Mediated Rejection (AMR)
C. Divella¹, A. Stasi¹, R. Franzin¹, F. Sallustio², C. Curci¹, G. Merlotti³, M. Quaglia³, L. Gesualdo¹, V. Cantaluppi¹, G. Castellano¹
¹Emergency and Organ Transplantation, University of Bari, Bari, Italy, ²Emergency and Organ Transplantation / Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy, ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
*Purpose: Recent data suggest a strong correlation between kidney injury and the occurrence of accelerated senescence process, known as “Inflammaging”. However, the role of TEC…
2019 American Transplant Congress
Patient Centered AUC-Monitoring of Tacrolimus Using Capillary Microsampling
M. T. Gustavsen, K. Midtvedt, N. Vethe, S. Bergan, A. Åsberg
Oslo University Hospital, Rikshospitalet, Oslo, Norway
*Purpose: To reduce unwanted side effects of Tacrolimus (Tac), improvement of dosing is warranted. Therapeutic drug monitoring (TDM) of Tac based on trough concentrations (C0)…