Articles tagged "Kidney transplantation"

2019 American Transplant Congress
LCP-Tacrolimus (LCPT; Envarsus XR) Dosing Considerations in De Novo Kidney Transplant Recipients
D. Cibrik¹, P. West-Thielke², S. J. Patel³, D. R. Stevens⁴, U. Meier-Kriesche⁴
¹University of Kansas Medical Center, Kansas City, KS, ²University of Illinois Hospital and Health Sciences System, Chicago, Chicago, IL, ³Veloxis Pharmaceuticals, Cary, NC, ⁴Veloxis Pharmaceuticals Inc., Cary, NC
*Purpose: Different initial dosing strategies were studied in Phase II/Phase III trials evaluating the pharmacokinetics, safety, and efficacy of LCPT in de novo kidney transplantation.…
2019 American Transplant Congress
Age-Related Effects on Thymic Output and Homeostatic T Cell Expansion Following Depletional Induction
H. Xu, H. Lee, A. Kirk
Surgery, Duke University, Durham, NC
*Purpose: Alemtuzumab induction leads to profound T cell depletion followed by a prolonged period of repopulation. Repopulation is thought to be influenced both by thymic…
2019 American Transplant Congress
Dialysis Facility Provider Transplant Knowledge after a Randomized Multilevel Intervention to Increase Kidney Transplant Referral and Evaluation in the Southeast
K. Maroney¹, R. Hamoda¹, L. McPherson¹, A. Cruz², S. Pastan¹, L. Plantinga¹, S. Paul¹, M. Ellis³, D. DuBay⁴, A. Reeves-Daniel⁵, R. Detwiler⁶, E. Hartmann⁷, H. Jones⁸, B. Thrasher⁹, C. Zayas¹⁰, L. Mulloy¹⁰, S. Wright¹¹, R. Patzer¹
¹Emory University, Atlanta, GA, ²IPRO Network of the South Atlantic, Raleigh, NC, ³Duke University, Durham, NC, ⁴Medical University of South Carolina, Charleston, SC, ⁵Wake Forest Health Transplant Center, Winston-Salem, NC, ⁶UNC Center for Transplantation, Chapel Hill, NC, ⁷Piedmont Transplant Institute, Atlanta, GA, ⁸Vidant Medical Center Transplant Services, Greenville, NC, ⁹Carolinas Transplant Center, Charlotte, NC, ¹⁰Augusta University, Augusta, GA, ¹¹IPRO Network of the South Atlantic, Morrisville, NC
*Purpose: Dialysis facility provider kidney transplantation (KTx) knowledge influences patient transplant access. The Reducing Disparities in Access to kidNey Transplantation (RaDIANT) Regional Study is a…
2019 American Transplant Congress
Replication of Diagnostic Biomarkers Using Orthogonal State-of-the-Art Technologies
M. Cassidy, B. Dooley, A. Verma, H. Yang, T. Muthukumar, R. Ding, C. Li, C. Snopkowski, B. Botticelli, S. Albakry, E. Edusei, M. Lubetzky, D. Dadhania, J. Lee, O. Elemento, M. Suthanthiran
WCM, New York, NY
*Purpose: The failure to reproduce scientific findings (McNutt M. Science 2014;343:229, Baker M. Nature 2016;53:452) has brought to the forefront the need for replication studies…
2019 American Transplant Congress
Distinct Delayed Classical Complement Pathway Activation Highlights Transition of Ischemic Acute Kidney Injury to Chronic Kidney Disease with Interstitial Fibrosis/Tubular Atrophy
S. Kumar, S. Jordan
Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Ischemia reperfusion Injury (IRI)-induced AKI of the renal allograft frequently leads to delayed graft function (DGF). Patients with DGF suffer from prolonged hospitalization with…
2019 American Transplant Congress
Impact of IgG Subclass and C1q Binding Donor-Specific HLA Antibodies on Antibody Mediated Rejection in Kidney Transplant Recipients
H. Lee¹, J. Ryu¹, S. Yun¹, T. Ban², E. Ko², C. Yang², E. Oh¹
¹Department of Laboratory Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ²Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: Donor specific HLA antibody (DSA) is a leading cause of antibody mediated rejection (AMR) and graft loss in kidney transplants. It is known that…
2019 American Transplant Congress
Automated Histology Lesion Interpretation in Kidney Transplant Biopsies Shows That Pathologists Often Deviate from Banff Guidelines
K. S. Madill-Thomsen¹, J. Reeve², G. Bohmig³, F. A. Eskandary⁴, A. Perkowska-Ptasinska⁵, M. Myslak⁶, P. F. Halloran and the INTERCOMEX Study Group¹
¹University of Alberta, Edmonton AB, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³Medical University of Vienna, Vienna, Austria, ⁴Medical University of Vienna, Edmonton AB, AB, Canada, ⁵Medical University of Warsaw, Warsaw, Poland, ⁶Pomeranian Medical University, Szczecin, Poland
*Purpose: Histologic diagnosis of kidney transplant biopsies requires an expert pathologist using Banff guidelines to interpret features. Some problematic guidelines require experts to use professional…
2019 American Transplant Congress
Temporal Trends of First-Year Mortality on the Adult Kidney-Only Wait List in the United States
F. Tedla, A. Gruessner, I. Puri, A. Brar, N. Sumrani, D. John, J. Renz, R. Gruessner, M. Salifu
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Evaluation of kidney transplant candidacy must balance risk of mortality with and without transplant. Trends in first-year mortality could inform patterns of risk avoidance…
2019 American Transplant Congress
Effect of Everolimus on IgM and IgG Memory B Cell Growth and Survival In Vitro and Applications for Effective Administration in Clinical Practice
Y. Matsuda
Osaka University Graduate School of Medicine, Osaka, Japan
*Purpose: Everolimus (EVR), which is converted from CNI, is reported to improve renal function and reduce renal toxicity, DSA production, and rejection development. However, there…
2019 American Transplant Congress
Relationship between Comorbilities and Infectious Disease in Kidney Transplant Recipients Receiving Rituximab
A. Molina-Andújar¹, E. Hermida¹, J. Rovira², F. Cofan¹, P. Ventura-Aguiar¹, N. Esforzado¹, V. Torregrosa¹, D. Cucchiari¹, E. de Souza¹, I. Revuelta¹, F. Oppenheimer¹, F. Diekmann¹, G. Piñeiro¹
¹Renal Transplant Unit, Hospital Clínic de Barcelona, Barcelona, Spain, ²Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain
*Purpose: Rituximab is commonly used in the context of kidney transplantation. Evidence about infectious complications and its relationship with predictive factors is scarce. The aim…